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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Machine learning 27 (1997), S. 7-50 
    ISSN: 0885-6125
    Keywords: model selection ; complexity regularization ; cross validation ; minimum description length principle ; structural risk minimization ; vc dimension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract We investigate the problem of model selection in the setting of supervised learning of boolean functions from independent random examples. More precisely, we compare methods for finding a balance between the complexity of the hypothesis chosen and its observed error on a random training sample of limited size, when the goal is that of minimizing the resulting generalization error. We undertake a detailed comparison of three well-known model selection methods — a variation of Vapnik's Guaranteed Risk Minimization (GRM), an instance of Rissanen's Minimum Description Length Principle (MDL), and (hold-out) cross validation (CV). We introduce a general class of model selection methods (called penalty-based methods) that includes both GRM and MDL, and provide general methods for analyzing such rules. We provide both controlled experimental evidence and formal theorems to support the following conclusions: •Even on simple model selection problems, the behavior of the methods examined can be both complex and incomparable. Furthermore, no amount of “tuning” of the rules investigated (such as introducing constant multipliers on the complexity penalty terms, or a distribution-specific “effective dimension”) can eliminate this incomparability. •It is possible to give rather general bounds on the generalization error, as a function of sample size, for penalty-based methods. The quality of such bounds depends in a precise way on the extent to which the method considered automatically limits the complexity of the hypothesis selected. •For any model selection problem, the additional error of cross validation compared to any other method can be bounded above by the sum of two terms. The first term is large only if the learning curve of the underlying function classes experiences a phase transition” between (1-γ)m and m examples (where gamma is the fraction saved for testing in CV). The second and competing term can be made arbitrarily small by increasing γ. •The class of penalty-based methods is fundamentally handicapped in the sense that there exist two types of model selection problems for which every penalty-based method must incur large generalization error on at least one, while CV enjoys small generalization error on both.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the European Academy of Dermatology and Venereology 7 (1996), S. 0 
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Measures of the impact of severe eczema on patients’ lives are required for clinical, audit and political reasons, in order to argue for more resources for dermatology services. Objective The purpose of this study was to identify and measure the effects of severe eczema on quality of life of adults. Setting Dermatology hospital hased clinics throughout the United Kingdom. Methods Ninety-two adults with severe atopic eczema completed a questionnaire concerning the effect of their disease on their quality of life. Results The mean Dermatology Life Quality Index was 18 (60%). S.D. 7.1. with subsections relating to “symptoms and feelings” and “treatment effects” scoring highest. Disease comparison utility questions demonstrated that patients with severe eczema consider that having diabetes (ratio=1.21) or hypertension (1.38) would be better than having eczema, whereas having bronchitis (0.89) would be worse than having eczema (if diseases equal, ratio = 1). Over the long term, atopic eczema affects family life in 80% of patients and sexual relationships in 57%. 32% of patients had lost a median income of £5000 over the previous year because of their eczema, and those patients who were working had lost a median of 5 days from work over the previous year. 50% of patients would be prepared to give up 2 h or more a day in order to have normal skin, and 74% (49%) of patients would be prepared to pay £1000 (£10,000) or more for a cure. Conclusion This study confirms the major impact of severe atopic eczema on the quality of life of adults.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 65 (2003), S. 231-259 
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Abstract DNA microarray technology is revolutionizing many aspects of biological research, allowing the expression of many thousands of gene transcripts to be monitored simultaneously. This provides powerful tools for the genome-wide correlation of gene transcript levels with physiological responses and alterations in physiological states. To date, microarray analyses have been applied almost exclusively to a few model species for which the abundant gene sequence data permit the fabrication of whole-genome microarrays. However, many interesting physiological traits and responses are poorly expressed or absent in model species and may be better illustrated in nonmodel organisms. Comparative approaches to understanding function traditionally focus on species that by virtue of their unusual adaptations, lifestyles, and phylogeny are particularly suited to address a specific biological process or problem. In this review, we show that microarray technology can be successfully applied to these nonmodel species and used to generate new insights of comparative and evolutionary significance into animal function.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    [s.l.] : Macmillian Magazines Ltd.
    Nature 424 (2003), S. 201-205 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The direction of frequency-modulated (FM) sweeps is an important temporal cue in animal and human communication. FM direction-selective neurons are found in the primary auditory cortex (A1), but their topography and the mechanisms underlying their selectivity remain largely unknown. Here we ...
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 45 (1985), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The effects of muscimol and/or incubation temperature on the inhibition of [3H]flunitrazepam receptor binding by benzodiazepine receptor ligands were investigated. At 0°C muscimol decreased the Ki values for some ligands as displacers of [3H]flunitrazepam binding to brain-specific sites while increasing or having no effect on the Ki values for other ligands. The Ki values for some ligands are higher at 37°C than at 0°C but are reduced by muscimol at both 0° and 37°C. In contrast, the ligands whose Kt values are increased by muscimol either decreased or did not alter the Ki values at 37°C as compared to those at 0°C. Incubation of membranes at 37°C for 30 min accelerated γ-aminobutyric acid (GABA) release by 221% over that at 0°C. These results indicate that changes in incubation temperature alter benzodiazepine receptor affinity for ligands via GABA.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 103 (1980), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A new instrument has been developed and used to determine the effect of various materials on nail flexibility. It repeatedly flexes longitudinal nail sections through 90 degrees and records the number of flexions required to fracture each section.Immersion in water or a phospholipid-water preparation (PLW) greatly increases the flexibility of untreated and lipid extracted nails; immersion in mineral oil does not.Nail flexibility is directly related to the duration of their immersion in water. During water immersion, nail weight increases by 22% of its original weight within 2 h, and then decreases. The rapid increase in nail flexibility during water immersion is related to nail water content.It is possible to prolong the flexibility of previously hydrated nails by the application of PLW or mineral oil. PLW is more effective than water alone in prolonging flexibility of nails extracted with a mixture of acetone, water and acetic acid.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Recent experiments at the Joint European Torus [Rebut et al., Fusion Eng. Des. 22, 7 (1993)] aim to improve confinement quality in high-confinement-mode (H-mode) plasmas at high densities. Energy confinement time as predicted by the International Thermonuclear Experimental Reactor ITER-H98(y,2) scaling at densities near or in excess of 85% of the Greenwald density limit scaling has been obtained by (i) strong plasma shaping (triangularity 0.35〈δ〈0.5), or (ii) impurity seeding, or (iii) high-field side pellet injection. Slow peaking of central density without confinement degradation is observed. Loss of sawteeth and core impurity accumulation is prevented by central ion cyclotron resonance heating. In high triangularity and impurity seeded plasmas, reduction of average power loss associated with type I edge localized modes (ELMs) is found which is attributed to the occurrence of additional losses in between ELMs. Broad band magnetic fluctuations are seen which are reminiscent of regimes with small ELMs in other tokamaks. Plasma configurations have been varied to find best combinations of edge pedestal parameters and small ELM losses. © 2002 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 88 (2000), S. 3208-3219 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Optical absorption spectroscopy has been used to measure absolute, average gas phase densities of neutral copper, ground and metastable states, and neutral argon, metastable and resonance states, in an ionized physical vapor deposition plasma. Spectroscopic measurements were carried with a xenon arc lamp as a high intensity, continuum light source, and an optical multichannel detector. Copper radiative transitions in the wavelength range of 324.8–510.6 nm and argon radiative transitions in the 706.7–811.5 nm range were employed. The curve of growth method has been used to calculate the absolute line average densities from fractional absorption data. For a copper–argon plasma of neutral pressure 30 and 10 mTorr copper metastable state densities were found to lie in the range of 1010–1012 cm−3. Comparison of these densities with neutral copper densities derived from independent measurements of neutral copper flux at the substrate indicate gas phase temperatures greater than 1500 K under certain experimental conditions. These values of inferred temperatures indicate the copper metastable state density to be significant in comparison with neutral copper ground state densities at 10 and 30 mTorr with radio frequency heating power of 1 kW. The concentrations of argon 4s sublevels of the first excited state were found to be in the range of 4.5×108–1.5×1011 cm−3 for the experimental conditions studied. The ordering of the relative densities of the argon 4s sublevels and the variation of the lumped first excited state with experimental parameters are discussed. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1468-0394
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Computer Science
    Notes: Abstract: This article describes an intelligent knowledge-based object-oriented process planning (IKOOPP) system for the manufacture of progressive die plates. A die assembly is designed using a variety of standardised components based on a computer-aided design (CAD) system. A feature recognition module extracts all the pertinent geometrical properties and functional attributes of each machining feature from the CAD representation models. These properties and attributes are converted into an object-oriented representation. Knowledge of the functions of the machining feature allows process planning information to be automatically deduced. Specialised tool engineering knowledge are formulated as production rules or procedures to establish the required set of cutting tools, together with the machining allowances and sequence of operations.
    Type of Medium: Electronic Resource
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