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  • 1
    Electronic Resource
    Electronic Resource
    Antibiotics from basidiomycetes (1981)
    Springer
    Archives of microbiology 130 (1981), S. 223-227 
    Details
    ISSN: 1432-072X
    Keywords: Antibiotics ; Basidiomycetes ; Pleurotellus hypnophilus ; Galerina cephalotricha ; Hypnophilin ; Pleurotellol ; Pleurotellic acid ; Complicatic acid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Three new antibiotically active metabolites were isolated from cultures of the fungus Pleurotellus hypnophilus. The structures which are closely related to the coriolins were elucidated by spectroscopic methods. Hypnophilin (1) has a hirsutane sceleton whereas pleurotellol (2) and pleurotellic acid (3) are sesquiterpenoids with novel hirsutane skeletons. The common structural feature of all three metabolites is an α-methylene ketone moiety. The antibiotics inhibited the growth of several bacteria as well as of some fungi. In cells of the ascitic form of Ehrlich carcinoma RNA and DNA syntheses were more affected than protein synthesis. The mode of action was compared with the antimicrobial and cytotoxic effects of complicatic acid (4) and other α-methylene ketones and lactones from higher plants. All the compounds tested reacted rapidly with cysteine to form adducts which were almost devoid of biological activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00459523
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  • 2
    Electronic Resource
    Electronic Resource
    Antibiotics from basidiomycetes XVI. Antimicrobial and cytotoxic polyines from Mycena viridimarginata karst (1982)
    Springer
    Archives of microbiology 132 (1982), S. 194-196 
    Details
    ISSN: 1432-072X
    Keywords: Antibiotics ; Polyines ; Basidiomycetes ; Mycena viridimarginata ; 10-Hydroxy-undeca-2,4,6,8-tetraynamide ; 3,4,13-Trihydroxy-tetradeca-5,7,9,11-tetraynoic acid-γ-lactone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Two new biologically active polyines were isolated from cultures of the fungus Mycena viridimarginata. Their structures were elucidated by spectroscopic and chemical methods as 10-hydroxy-undeca-2,4,6,8-tetraynamide (1) and 3,4,13-trihydroxy-tetradeca-5,7,9,11-tetraynoic acid-γ-lactone (2). The main component (1) is highly antibiotically active and cytotoxic.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00508730
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  • 3
    Electronic Resource
    Electronic Resource
    Characterization of the ferrichrome A biosynthetic gene cluster in the homobasidiomycete Omphalotus olearius (2005)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 249 (2005), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Under iron deprivation Omphalotus olearius was found to produce the hydroxamate siderophore ferrichrome A. A gene cluster consisting of three genes: fso1, a nonribosomal peptide synthetase whose expression is enhanced in the absence of iron; omo1, a l-ornithine-N5-monooxygenase; and ato1, an acyltransferase probably involved in the transfer of the methylglutaconyl residue to N5-hydroxyorinithine was identified. The fso1 sequence is interrupted by 48 introns and its derived protein sequence has a similar structure to the homologous genes of Ustilago maydis and Aspergillus nidulans. This is the first report of a nonribosomal peptide synthetase gene and a biosynthetic gene cluster in homobasidiomycetes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/j.femsle.2005.06.013
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  • 4
    Electronic Resource
    Electronic Resource
    Pigments of Fungi, 68Part 67: M. Brenner, G. Mayer, A. Terpin, W. Steglich, Chem. Eur. J. 1997, 3, 64-68.. - Phlebiachrysoic Acids, New Inhibitors of Leukotriene Biosynthesis from Phlebia chrysocrea (Basidiomycetes) (1997)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1997 (1997), S. 313-316 
    Details
    ISSN: 0947-3440
    Keywords: Phlebia chrysocrea ; Fungi ; Phlebiachrysoic acids ; Inhibitors of leukotriene biosynthesis ; Quinones ; Pigments ; Natural products ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Five yellow 2-hydroxy-5-methoxybenzoquinones with C15 and C17 alkyl side chains were isolated from fruitbodies of the wood-rotting fungus Phlebia chryoscrea. The compounds, named phlebiachrysoic acids A-E are strong inhibitors of leukotriene biosynthesis and are responsible for the red colour reaction when the fruitbodies are touched with aqueous alkali.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.199719970207
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  • 5
    Electronic Resource
    Electronic Resource
    Influence of morphology and rheology on the production characteristics of the basidiomycete Cyathus striatus (1998)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 59 (1998), S. 525-533 
    Details
    ISSN: 0006-3592
    Keywords: fermentation ; basidiomycete ; rheology ; morphology ; pellet size ; scale-up ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The influence of the pellet morphology of the basidiomycete Cyathus striatus on the production of the antibiotics striatals A, B, and C was investigated. The main operating parameters in fermenters of different sizes were the tip speed and the volumetric power input. Different methods were developed for quantification of morphological characteristics. The apparent viscosity of the suspension was measured with a cylinder rheometer. Sediment density was measured with a sedimentation apparatus. Particle size distributions were recorded with an image analysis system. By means of the presented measuring methods, morphological characteristics could be determined and enabled an early assessment of the fermentation course and the antibiotics production. During the exponential growth phase of the fungus the relative sediment height correlated with the biomass concentration. The pellet morphology at this stage influenced the later production of striatals. The yield of the striatals was markedly influenced by pellet size and sediment density. Since these morphological characteristics determine the rheological properties of the culture the measurement of the apparent viscosity of the culture in the production phase allowed predictions of the production yield. © 1998 John Wiley & Sons, Inc. Biotechnol Bioeng 59: 525-533, 1998.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Antibiotika aus Basidiomyceten, III. Strobilurin A und B, antifungische Stoffwechselprodukte aus Strobilurus tenacellus (1978)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 111 (1978), S. 2779-2784 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Antibiotics from Basidiomycetes, III. Strobilurin A and B, Antifungal Metabolites from Strobilurus tenacellusThe structural elucidation of the strobilurins A and B (4, 5, respectively) is described. These compounds are 1-arylhexatrienes containing a terminal β-methoxyacrylate moiety.
    Notes: Die Konstitutionsaufklärung der Strobilurine A und B (4 bzw. 5) wird beschrieben. Es handelt sich um 1-Arylhexatriene, die eine endständige β-Methoxyacrylat-Gruppierung enthalten.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19781110806
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  • 7
    Electronic Resource
    Electronic Resource
    Antibiotika aus Basidiomyceten, XX Synthese von Strobilurin A und Revision der Stereochemie der natürlichen Strobilurine (1984)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1984 (1984), S. 1616-1625 
    Details
    ISSN: 0170-2041
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Antibiotics from Basidiomycetes, XX. - Synthesis of Strobilurin A and Revision of the Stereochemistry of Natural StrobilurinsCondensation of cinnamaldehyde (5) with 2-oxobutyric acid (6) leads to the (E,E)-keto acid 7 which is converted into (9E)-strobilurin (1a) via methyl ester 9 and Wittig reaction of the latter with (methoxymethylene)triphenylphosphorane. On irradiation 1a undergoes inversion at the double bond in position 9 and yields strobilurin A (1b) which is identical with the natural product. Due to this result the (9Z) stereochemistry has to be assigned to all natural strobilurins 1b-4b, contrary to former formulations. This assignment is further supported by spectral comparison of 1a and 1b as well as by thermal cyclization of 1b to the biphenyl derivative 11. The latter can also be obtained by condensation of methyl 2-(methoxymethylene)acetoacetate (13) with cinnamylidenetriphenylphosphorane (12). Base-catalyzed condensation of 13 yields dimethyl 4-hydroxyisophthalate (14).
    Notes: Kondensation von Zimtaldehyd (5) mit 2-Oxobuttersäure (6) liefert die (E,E)-Ketosäure 7, die nach Überführung in den Methylester 9 und Wittig-Reaktion mit (Methoxymethylen)triphenylphosphoran (9E)-Strobilurin A (1a) ergibt. Inversion der 9-Doppelbindung durch Belichten führt zu Strobilurin A (1b), das mit dem Naturprodukt identisch ist. Danach besitzen alle natürlichen Strobilurine 1b-4b im Gegensatz zu früheren Angaben die (9Z)-Konfiguration. Diese Zuordnung wird durch den spektroskopischen Vergleich von 1a und 1b sowie durch thermische Cyclisierung von 1b zum Biphenyl-Derivat 11 gesichert. 11 kann auch durch Reaktion von 2-(Methoxymethylen)acetessigsäure-methylester (13) mit Cinnamylidentriphenylphosphoran (12) erhalten werden. Kondensation von 13 unter basischen Bedingungen liefert 4-Hydroxyisophthalsäure-dimethylester (14).
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.198419840910
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  • 8
    Electronic Resource
    Electronic Resource
    Antibiotika aus Basidiomyceten, 28. Hydroxystrobilurin D, ein antifungisches Antibiotikum aus Kulturen von Mycena sanguinolenta (Agaricales) (1988)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1988 (1988), S. 405-409 
    Details
    ISSN: 0170-2041
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Antibiotics from Basidiomycetes, 281). - Hydroxystrobilurin D, an Antifungal Antibiotic from Cultures of Mycena sanguinolenta (Agaricales)The isolation of the antifungal antibiotic hydroxystrobilurin D (3) from cultures of the gilled toadstool Mycena sanguinolenta is described. Its structural elucidation rests on spectroscopic investigations as well as on its thermolytic conversion into the biphenyl derivative 6 which undergoes subsequent acid-catalysed cyclisation to yield the 2H-1,5-benzodioxepine derivative 7. The latter compound proved to be suitable for an assignment of the substituents at the phenyl ring and the determination of the absolute configuration by means of Horeau's method. The biological activities of 3 are discussed.
    Notes: Aus Kulturen des Blätterpilzes Mycena sanguinolenta wird das antifungische Hydroxystrobilurin D (3) isoliert. Seine Strukturaufklärung beruht auf spektroskopischen Untersuchungen sowie auf der Thermolyse zum Biphenylderivat 6, das sich säurekatalysiert in das 2H-1,5-Benzodioxepin-Derivat 7 umwandelt. 7 gestattet die Festlegung der Substituentenanordnung am Benzolring und die Bestimmung der absoluten Konfiguration nach Horeau. Die biologischen Eigenschaften von 3 werden diskutiert.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.198819880506
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  • 9
    Electronic Resource
    Electronic Resource
    9-Methoxystrobilurine - Bindeglieder zwischen Strobilurinen und OudemansinenProfessor Werner Tochtermann zum 60. Geburtstag gewidmetAntibiotica aus Basidiomyceten, 48. Mitteilung. Diese Arbeit wurde von der Deutschen Forschungsgemeinschaft gefördert. - 47. Mitteilung: R. Velten, D. Klostermeyer, B. Steffan, W. Steglich, A. Kuschel, T. Anke, J. Antibiot. 1994, 47, 1017-1024. (1995)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 107 (1995), S. 255-257 
    Details
    ISSN: 0044-8249
    Keywords: Antibiotica ; Fungizide ; Oudemansine ; Strobilurine ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19951070231
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  • 10
    Electronic Resource
    Electronic Resource
    New Triquinane-Type Sesquiterpenoids from Macrocystidia cucumis (Basidiomycetes) (1998)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1998 (1998), S. 73-79 
    Details
    ISSN: 1434-193X
    Keywords: Macrocystidia cucumis ; Cucumins ; Hirsutanes ; Sesquiterpenoids ; Antibiotics ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Arthrosporone (1) and eight new triquinane-type sesquiterpenoids have been isolated from mycelial cultures of the agaric Macrocystidia cucumis. The cucumins A-D (2, 4-6) are highly unsaturated hirsutane derivatives, whereas the cucumins E-G (7-9) represent a new type of linear triquinanes. Cucumin H (10) is a new member of the ceratopicane group. The absolute configuration of cucumin F (8) was assigned by 1H-NMR analysis of the corresponding Mosher esters. Two further metabolites were identified as cyclo(phenylalanylprolyl) (12) and cyclo(leucylprolyl) (13). Cucumin A (2) exhibits antibacterial and cytotoxic activities.
    Type of Medium: Electronic Resource
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