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  • 1
    Electronic Resource
    Electronic Resource
    Die maligne Entartung eines Riesenzelltumors am distalen Radiusende (2000)
    Springer
    Der Orthopäde 29 (2000), S. 677-683 
    Details
    ISSN: 1433-0431
    Keywords: Schlüsselwörter Riesenzelltumor des Knochens • Maligne Transformation • DNS-Zytometrie ; Keywords Giant-cell tumor of bone • Malignant transformation • DNA-cytometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract The GCT is a primary bone tumor of intermedier dignity, whereby the forecast of the biological behaviour and outcome is impossible on the base of the conventional histological diagnosis. The authors observed in one of their GCT-patients a malignant transformation of the formerly benign tumor. Through announcement of their case the authors want to call the attention to the importance of the DNA-Cytophotometry and to their possible future additional role in the diagnostics of the GCT and in the prediction of their biological behaviour.
    Notes: Zusammenfassung Der Riesenzelltumor ist ein primärer Knochentumor von intermediärer Dignität. Die Vorhersage des biologischen Verhaltens und des Krankheitsverlaufs ist nach konventionellen histologischen Diagnosemaßnahmen kaum möglich. Anhand einer Fallbeschreibung einer malignen Entartung eines Riesenzelltumors am distalen Radius wird die Möglichkeit und die Bedeutung der DNS-Zytophotometrie dargestellt. Mit Hilfe dieses Untersuchungsverfahrens kann das biologische Verhalten der Riesenzelltumoren besser vorhergesagt werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00003754
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  • 2
    Electronic Resource
    Electronic Resource
    Examination and evaluation of surgical margins in bone tumours (1993)
    Springer
    International orthopaedics 17 (1993), S. 93-97 
    Details
    ISSN: 1432-5195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les auteurs présentent un procédé objectif d'évaluation des marges chirurgicales et du caractère radical de la chirurgie conservatrice des membres dans le traitement des tumeurs osseuses. L'examen de la région opérée par tomodensitométrie (TDM) et IRM étant généralement impossible en raison de la présence de matériel métallique implanté, ils recommandent de pratiquer l'examen TDM et IRM de la pièce opératoire et de le comparer avec les images pré-opératoires. La TDM montre mieux les modifications de l'os et particulièrement la rupture de la corticale tandis que l'IRM précise mieux l'extension extra-osseuse et intra-médullaire de la tumeur. Il est donc recommandé de combiner les deux méthodes d'examen. Une résection intralésionelle est une indication absolue, une résection marginale une indication relative de réintervention.
    Notes: Summary An objective method of evaluating surgical margins and the extent of limb-preserving surgery is described in a study of 10 malignant bone tumours. The resected specimen was imaged by computerised tomography and magnetic resonance, and the appearances compared with the preoperative images of the tumour. CT was better than MR for detecting bony changes, but MR was more satisfactory for showing the extraosseous and intramedullary outline of the tumour. These two methods should therefore be combined. Intralesional excision is an absolute indication; marginal excision a relative indication for reoperation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00183549
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  • 3
    Electronic Resource
    Electronic Resource
    Calcitonin therapy of aneurysmal bone cysts (1992)
    Springer
    Journal of cancer research and clinical oncology 119 (1992), S. 61-65 
    Details
    ISSN: 1432-1335
    Keywords: Calcitonin hormone ; Aneurysmal bone cyst
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Seven aneurysmal bone cysts (ABC) were treated with the hormone calcitonin. Six of the cysts, which were hypovascular responded well to the calcitonin administered directly into the cyst. Ossification and rebuilding of the ABC occurred after some months in every case. One hypervascularized ABC, however, failed to respond either to embolotherapy or to the calcitonin hormone treatment. The authors recommend calcitonin administration as a useful non-invasive method for the treatment of hypovascular ABC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01209491
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  • 4
    Electronic Resource
    Electronic Resource
    Multicentric extraabdominal desmoid tumour: A case report (1994)
    Springer
    Journal of cancer research and clinical oncology 120 (1994), S. 490-493 
    Details
    ISSN: 1432-1335
    Keywords: Multicentric ; Desmoid ; Extraabdominal ; Radiotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The very rare condition of multicentric desmoid tumours involving two distant and apparently independent sites is reported in a 17-year-old man. The tumours grew simultaneously and reached approximately equal size. No evidence of familiar polyposis or any other feature of Gardner's syndrome were noted. The proximal desmoid tumour developed from the left hip region and extended into the femoral bone, whereas the distal mass was attached to the left popliteal fossa infiltrating the flexor muscles, the nerves and vessels. On the basis of the good results published recently in the literature and our own earlier experiences, the intralesional resection of the desmoid tumours was completed with postoperative fractionated radiotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01191803
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  • 5
    Electronic Resource
    Electronic Resource
    The prognostic significance of DNA cytophotometry and proliferation index (Ki-67) in giant cell tumors of bone (1999)
    Springer
    International orthopaedics 23 (1999), S. 315-319 
    Details
    ISSN: 1432-5195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé  Les auteurs ont examiné 1’anomalie chromosomique de DNA á 1’aide de cytophotometrie de frottis; et 1’activité de proliferation par le moyen de 1’immuno- histochimie Ki-67 MIB dans 69 tumeurs de cellules géantes de 50 patients choisis accidentellement. lls ont évalué les résultats en les comparant aux données cliniques disponibles. Parmi les 46 tumeurs primaires 63% ont manifesté un caractère diploide et 37% un caractère aneuploide. On a observé une proportion de recidive significativement plus élevée (P=0.026) dans les tumeurs aneuploides (64%) que dans les tumeurs diploides (31%). Au cours des récidives on a remarquè une augmentation tant dans la proportion des tumeurs aneuploides que dans 1’indice de proliferation mais en ce dernier 1’augmentation n’était pas significative. Le caractère aneuploide ne signifie pas forcément une tendance univoque á la transformation maligne cependant dans les tumeurs aneuploides récidivantes il est nécessaire de suivre la maladie avec beaucoup de soin et comme intervention chirurgicale on conseille une excision large au lieu du curettage intralésionel.
    Notes: Abstract  We studied DNA ploidy by smear cytophotometry and proliferation activity by Ki-67 MIB immunohistochemistry in 69 primary and recurrent giant cell tumors (GCT) from 50 randomly selected patients. The obtained results were evaluated with comparisons made to the available clinical data. From the 46 primary tumors 63% showed diploidy and 37% aneuploidy. A significantly (P=0.026) higher recurrence rate (64%) was observed in aneuploid than in diploid tumors (31%). In the course of the recurrences, both the ratio of aneuploid tumors as well as the proliferation index of the tumors increased, though the degree of the latter was non-significant. Aneuploidy did not mean an unambiguous tendency towards malignant transformation; however, a close follow-up of recurrent aneuploid tumors, and wide excision of the recurrence instead of intralesional curettage are the recommended procedures. The DNA cytophotometry and proliferation index of GCTs – as compared to other histologic examinations – are of prognostic value in the evaluation of the recurrence potential of the GCTs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002640050381
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  • 6
    Electronic Resource
    Electronic Resource
    Mid-foot reconstruction following involvement of five bones by giant cell tumor (2000)
    Springer
    Skeletal radiology 29 (2000), S. 664-667 
    Details
    ISSN: 1432-2161
    Keywords: Keywords Giant cell tumor ; Multiple mid-foot bones ; Reconstructive surgery ; Radiography ; MRI
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We report on a patient who had giant cell tumor involving multiple bones of the mid-foot. The tumor originated from the navicular bone, but also destroyed the cuboid, and all cuneiform bones. This unusual presentation of giant cell tumor presented a therapeutic challenge for the surgeons. The patient was treated with en bloc resection and the bony defect replaced with a massive iliac crest graft which united within 9 months and has remained stable for 7 years without local recurrence, and with excellent function of the foot.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002560000274
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