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  • 1
    Electronic Resource
    Electronic Resource
    Redox-active monomeric and polymeric surfactants (1993)
    s.l. : American Chemical Society
    Langmuir 9 (1993), S. 77-85 
    Details
    ISSN: 1520-5827
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/la00025a019
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Computation of frequency-to-spatial transform by olfactory bulb glomeruli (1991)
    Springer
    Biological cybernetics 65 (1991), S. 407-414 
    Details
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract A physiological simulation of 2.5% of the input and inhibitory neurons and 25% of the primary mitral/tufted cells in a single mammalian olfactory bulb glomerulus was constructed. This physiological simulation used the integrate-and-fire paradigm with realistic activation curves and synaptic delays. The dendritic integration incorporated non-linear interactive effects of individual cell excitatory and inhibitory post-synaptic potentials (PSPs) from both axodendritic and dendrodendritic synaptic contacts. Refractory periods for granule-cell inhibition of mitral/tufted cell activity lead to relatively fixed-frequency rhythmic activity in the glomerulus, independent of the input frequency from the olfactory nerve. Though the frequency of mitral/ tufted cell firing in bulb was approximately independent of input frequency, the number of cells active in the glomerulus was a roughly-linear function of input frequency to the glomerulus, indicating the mechanism's ability to function as a frequency-to-spatial encoder.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00216975
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  • 3
    Electronic Resource
    Electronic Resource
    RARE EARTH ELEMENT CONCENTRATIONS IN USGS AND CCRMP IGNEOUS ROCK STANDARDS DETERMINED BY HIGH PERFORMANCE ION CHROMATOGRAPHY (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Geostandards and geoanalytical research 17 (1993), S. 0 
    Details
    ISSN: 1751-908X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Eleven rare earth elements (REE) have been determined in ten USGS and two CCRMP igneous rock standards using high performance ion chromatography. Duplicate analyses of two or more separately prepared aliquots of each sample were undertaken; reproducibility was better than 5% for each of the REE. In most cases, the results compare closely with published REE values for those samples for which the REE are well characterised. Where the results for individual elements are in disagreement with published data, the more erratic patterns yielded by the earlier data when plotted on chondrite-normalised REE diagrams suggest that values determined in this study are of greater accuracy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1751-908X.1993.tb00124.x
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  • 4
    Electronic Resource
    Electronic Resource
    Sizing of biological samples by photosedimentation techniques (1990)
    s.l. : American Chemical Society
    Biotechnology progress 6 (1990), S. 255-261 
    Details
    ISSN: 1520-6033
    Source: ACS Legacy Archives
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bp00004a004
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    High-resolution particle size analysis in biotechnology process control (1991)
    s.l. : American Chemical Society
    Biotechnology progress 7 (1991), S. 377-379 
    Details
    ISSN: 1520-6033
    Source: ACS Legacy Archives
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bp00010a013
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    A correlation for the effective strength of Escherichia coli during homogenization (1993)
    s.l. : American Chemical Society
    Biotechnology progress 9 (1993), S. 109-112 
    Details
    ISSN: 1520-6033
    Source: ACS Legacy Archives
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bp00019a017
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  • 7
    Electronic Resource
    Electronic Resource
    Gene expression RNA interference in adult mice (2002)
    [s.l.] : Nature Publishing Group
    Nature 418 (2002), S. 38-39 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] RNA interference is an evolutionarily conserved surveillance mechanism that responds to double-stranded RNA by sequence-specific silencing of homologous genes. Here we show that transgene expression can be suppressed in adult mice by synthetic small interfering RNAs and by small-hairpin RNAs ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/418038a
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  • 8
    Electronic Resource
    Electronic Resource
    Sudden Death in the Community (2003)
    350 Main Street , Malden , MA 02148-5018 , USA , and 9600 Garsington Road , Oxford OX4 2DQ , UK . : Blackwell Science Inc
    Journal of cardiovascular electrophysiology 14 (2003), S. 0 
    Details
    ISSN: 1540-8167
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: About one fifth of all deaths occur suddenly and unexpectedly, often as the first manifestation of heart disease. Several tests have been developed during the past 2 decades for risk stratification of such an event, but only a minority of victims can be identified as being at high risk before sudden death occurs. Improving the results of out-of-hospital resuscitation attempts is of crucial importance. Use of the automated external defibrillator is rapidly increasing worldwide. However, the defibrillator must be used within minutes after the onset of cardiac arrest, and rapid recognition and localization of the victim are essential. The development of a device that constantly monitors vital signs and can diagnose cardiac arrest, generate an alarm, and transmit the location of the victim could be an important step in improving the results of cardiac resuscitation. (J Cardiovasc Electrophysiol, Vol. 14, pp. S104-S107, September 2003, Suppl.)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1540-8167.14.ss9.1.x
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  • 9
    Electronic Resource
    Electronic Resource
    The Effect of Flunarizine and Ryanodine on Acquired Torsades de Pointes Arrhythmias in the Intact Canine Heart (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cardiovascular electrophysiology 6 (1995), S. 0 
    Details
    ISSN: 1540-8167
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Flunarizine and Ryanodine in Acquired TdP. Introduction: Ryanodine, a specific blocker of the Ca2+ release channel of the sarcoplasmic reticulum, and flunarizine, a[Ca2+], overload blocker, possess antiarrhythmic effects against delayed after depolarizations (DADs) and DAD-dependent arrhythmias. In vitro controversy exists about their effect on early after depolarizations (EADs): no effect was reported on cesium-induced EADs, while ryanodine did prevent EADs induced by isoproterenol. To study the possible role of intracellular Ca2+ overload in acquired EAD-dependent torsades de pointes (TdP) arrhythmias, we tested the effects of flunarizine and ryanodine in our animal model of TdP. Methods and Results: Anaesthetized dogs with chronic AV block received d-sotalol or almokalant followed by pacing. A subset of dogs with reproducible TdP (≥ 3 times) were selected to receive flunarizine (2 mg/kg per 2 min) or ryanodine (10 μg/kg per 10 min). After dsotalol, TdP was induced at a mean cycle length of the idioventricular rhythm (CL-IVR) of 2070 ± 635 msec and a QT(U) interval of 535 ± 65 msec. Induction of TdP was prevented by flunarizine in all experiments (8/8): electrophysiologically this was associated with a decrease in CL-IVR, QT(U), and QTc interval (390 ± 100 to 320 ± 45, P 〈 0.05). Ryanodine prevented TdP induction in 4 of 5 experiments and decreased the CL-IVR, QT(U), and the QTc interval from 385 ± 75 to 320 ± 20 msec (P 〈 0.05). Both drugs also suppressed the almokalant-induced EADs and related ectopic activity. This antiarrhythmic action corresponded with the inability to reinduce TdP by pacing. Conclusions: Blockade of the Ca2+ release channel of the sarcoplasmic reticulum by ryanodine or the reduction of [Ca2+] overload by flunarizine prevents induction of EAD-dependent acquired TdP arrhythmias, suggesting a role for [Ca2+]i overload in acquired TdP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1540-8167.1995.tb00770.x
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  • 10
    Electronic Resource
    Electronic Resource
    A randomized, placebo-controlled trial of calcium supplementation for decreased bone density in corticosteroid-using patients with inflammatory bowel disease: a pilot study (1996)
    Oxford BSL : Blackwell Science
    Alimentary pharmacology & therapeutics 10 (1996), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: Patients with inflammatory bowel disease (IBD) have a high prevalence of osteoporosis. A number of studies have found that corticosteroid use is associated with the development of osteoporosis in these patients. Calcium supplementation may be of benefit in corticosteroid-induced osteoporosis and calcium may be a nutrient that patients with IBD lack. Aim: To test the benefit of calcium supplementation on bone density in a pilot study over a 1-year period, in a group of corticosteroid-using patients with IBD, in a randomized, double-blind, placebo-controlled treatment study. Methods: Corticosteroid-using patients with IBD including males over the age of 18 years and premenopausal females, were randomized to receive either calcium carbonate 1000 mg plus vitamin D 250 IU (Oscal) or an identically matched placebo. Dual energy X-ray absorptiometry measurements of bone density were obtained at entry and at 1 year. At entry, and every 3 months thereafter, serum was collected for the measurement of haemoglobin, biochemistry and bone hormones. Simultaneously a 24-h urine collection was analysed for calcium excretion and creatinine clearance, and a 4-day food record was collected to document dietary calcium and vitamin D ingestion. Results: We found a high prevalence of moderately severe decreased bone density in corticosteroid-using patients with IBD. The dose of prednisone in the year prior to study entry was inversely correlated with bone density at the hip (R=-0.67, P=0.004). At study entry serum osteocalcin was inversely correlated with corticosteroid dose in the year prior to the study (R=-0.64, P=0.02) and at study end, directly correlated with the percentage change in spine bone density (R=0.59, P=0.01). The dietary calcium intake of these patients was close to the current RDA (recommended daily intake) for premenopausal, post-adolescent adults. Calcium supplementation with small extra doses of vitamin D conferred no obvious benefit to bone density at the end of 1 year. There was no correlation between oral calcium ingestion and bone mass measurements. Both the treatment and placebo groups' bone density remained relatively stable at 1 year, suggesting that bone loss in corticosteroid-using patients may peak early into the use of the corticosteroids. Conclusions: Calcium supplementation (1000 mg/day) conferred no significant benefit to bone density at 1 year in patients with corticosteroid-using IBD patients with osteoporosis. Future investigations should explore other therapeutic avenues that may have greater effects on increasing bone density in patients who already have considerable osteoporosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.1996.63205000.x
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