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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 55 (1999), S. 0 
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Between February 1989 and August 1990, the upper Thames estuary contained 23 species of fish. Fish numbers were higher and relatively constant in the uppermost part of the estuary. Number of species was augmented in summer from fresh water and from downstream, coinciding with high temperature, low flow and high salinity. The eight most abundant species contributed to 98·5% of the total number. Flounder Pleuronectes flesus, dace Leuciscus leuciscus and perch Perca fluviatilis, recruited from May to August, and common goby Pomatoschistus microps, roach Rutilus rutilus and chub Leuciscus cephalus, from August to November. The upper estuary (salinity 0·34–2·96 p.s.u.) formed a species transition area between the freshwater but salinity-resistant roach, chub, and gudgeon Gobio gobio upstream, and the estuarine eurhyhaline common goby and flounder downstream. The three-spined stickleback Gasterosteus aculeatus and cyprinids were more abundant at upstream while perch was more abundant at downstream sites. High abundances of gudgeon, chub and roach were associated with high transparency and dissolved oxygen and low salinity, while high abundances of perch were associated with high salinity and low transparency. Dace and three-spined stickleback were associated with high dissolved oxygen and low pH, and common goby with high pH. Flounder showed no clear preferences.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of sol gel science and technology 2 (1994), S. 729-735 
    ISSN: 1573-4846
    Keywords: laser densification ; optical waveguides ; gel: silica
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Channel waveguides are important components in optical signal processing. A new method is described for producing such waveguides with high design flexibility. The channel waveguides are produced using CO2 laser densification of partially densified gel-silica matrices (Type VI optical silica). Critical processing conditions include pore size and initial density of the matrix, laser power, translational speed of the sample, distance between sample and focusing lens, and ambient humidity. Channel waveguides less than 500 µm wide were produced in gel-silica substrates of different pore sizes and bulk densities throgh laser densification. Optically transparent waveguides were obtained for speeds of the sample over 1.4 cm/s and laser power settings ranging between 12 and 16 mA. Substrates with three different pore sizes were analyzed, i.e, 12, 30 and 45 Å, with densities varying from 1.1 g/cc to 2.1 g/cc. Fourier transform infrared microspectrometry of the densified regions showed that IR shifts ranging from 1 to 38 cm−1 in the peak position of the Si-O-Si stretching vibrational mode were achieved. This corresponds to changes of index of refraction ranging from 0.01 to 0.20. The experiments show also that the larger the pore size the wider is the range of parameters for producing effective waveguides.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of sol gel science and technology 2 (1994), S. 647-655 
    ISSN: 1573-4846
    Keywords: gel silica optics ; silica ; porosity ; pore distributions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A new generation of silica optics has resulted from alkoxide-based sol-gel processing of silica including: net shape transmissive optical elements, surface diffractive optics, inorganic doped GRIN optics, organic impregnated optical composites such as dye lasers and scintillators, optics with internal diffraction gratings, laser densified microoptical lenses and arrays, and laser densified waveguides. Processing control of the ultrastructure of the monolith at the time of gelation and during aging is essential to producing the optical devices together with chemical and thermal stabilization of the surface of the pore network prior to densification or impregnation. The process control variables for gel-silica optics are summarized together with spectroscopic analysis and molecular orbital calculations that explain how and why the thermal-chemical processing controls work at a molecular level.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical microbiology & infectious diseases 11 (1992), S. 71-73 
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Experiments were performed in vivo in a mouse model of acute toxoplasmosis to evaluate the effectiveness of the combination azithromycin/sulfadiazine. Azithromycin alone or sulfadiazine alone, at doses that did not provide any protection against death due to toxoplasmosis, were remarkably and significantly synergistic against murine toxoplasmosis when administered in combination.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical microbiology & infectious diseases 10 (1991), S. 519-524 
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The macrolide antibiotics azithromycin, roxithromycin and spiramycin were examined in parallel for in vivo activity againstToxoplasma gondii. Azithromycin was considerably more active in protecting mice against death due to acute toxoplasmosis even when the other two antibiotics were used at twice its dose. The higher activity of azithromycin prompted a further examination of its activity against five different strains ofToxoplasma gondii, including two isolated from patients with AIDS. Although variable degrees of protection against death were noted, treatment with 200 mg/kg/day for ten days was sufficient to promote survival of 100 % of mice infected with inocula as high as 1 × 105 tachyzoites ofToxoplasma gondii. 90 % of mice inoculated with 1 × 105 tachyzoites of strain MO, isolated from an AIDS patient, and treated orally with 200 mg/kg/day for ten days survived the infection whereas only 40 % of mice infected with the same inoculum of the SOU strain, also isolated from an AIDS patient, survived. Tissue concentrations of azithromycin were examined in treated infected and non-infected mice. In both groups of mice azithromycin attained high concentrations in liver, spleen and heart, which exceeded concurrent serum levels by 25- to 200-fold. The concentrations in the brain were almost tenfold higher than the concentrations in serum after treatment with 200 mg/kg/day for ten days. Moreover, the concentrations in brains of infected mice were approximately two-fold higher than in brains of non-infected mice.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical microbiology & infectious diseases 6 (1987), S. 1-2 
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical microbiology & infectious diseases 15 (1996), S. 394-397 
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effectiveness of combinations of rifabutin with atovaquone, clindamycin, pyrimethamine, or sulfadiazine in the treatment of toxoplasmic encephalitis in a murine model was investigated. Doses of each drug that were not effective in reducing inflammation in the brain of mice with toxoplasmic encephalitis when used alone were used in combination with a dose of rifabutin which was minimally effective. At the end of each period of therapy (15 or 30 days), brains of mice were examined histopathologically and the severity of the inflammatory lesions scored. Treatment with rifabutin in combination with pyrimethamine or sulfadiazine did not reduce brain inflammation significantly when compared to treatment with each drug alone. In contrast, treatment with rifabutin plus atovaquone for 15 or 30 days or with rifabutin plus clindamycin for 15 days resulted in statistically significant reduction in the inflammation. These results suggest that combining rifabutin with certain drugs that are active againstToxoplasma gondii may be useful for the treatment of toxoplasmic encephalitis in humans and may allow for a reduction in dosage of either or both drugs with a resulting reduction in untoward side effects.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1420-9071
    Keywords: Trypanosoma cruzi ; Chagas' disease ; macrophages ; mouse fibroblasts
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Two subpopulations of circulating parasites displaying different abilities to infect mammalian cells and to cause lethal infection when inoculated into normal mice were demonstrated in the blood of mice acutely infected withT. cruzi. Parasites of one subpopulation rapidly penetrated mouse fibroblasts and were readily phagocytized by normal mouse peritoneal macrophages whereas parasites of the other subpopulation showed little ability to invade non-phagocytic cells and resisted phagocytosis. Inoculation of organisms of this latter population into mice resulted in infections with lower parasitemias and longer time to death as compared to controls inoculated with organisms from a population containing both types of parasites. When a population of parasites containing both types of trypanosomes was cultured in acellular medium at 28°C a decrease in the number of parasites was noted to occur in the initial days of culture. This decrease was not noted when parasites of the subpopulation of trypanosomes resistant to phagocytosis were cultured similarly.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  The capacity of Toxoplasma gondii surface protein SAG2 to induce protective immunity against the parasite in mice was studied using recombinant SAG2 expressed as a glutathione-S-transferase (GST) fusion protein incorporated into immune stimulating complexes (iscoms). Immunization with the iscoms resulted in the production of antibodies recognizing SAG2 as well as GST. After oral challenge infection with T. gondii oocysts or tissue cysts, no protective effect was observed. On the contrary, mice immunized with fusion SAG2 or with GST iscoms died earlier than non-immunized control mice.
    Type of Medium: Electronic Resource
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