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  • 1
    Electronic Resource
    Electronic Resource
    Hydrogen ion cotransport by the renal brush border glutamate transporter (1983)
    s.l. : American Chemical Society
    Biochemistry 22 (1983), S. 5459-5463 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00292a030
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  • 2
    Electronic Resource
    Electronic Resource
    Heterogeneity of Anion Exchangers Mediating Chloride Transport in the Proximal Tubule (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 574 (1989), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1989.tb25139.x
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  • 3
    Electronic Resource
    Electronic Resource
    Calcium oxalate urolithiasis in mice lacking anion transporter Slc26a6 (2006)
    [s.l.] : Nature Publishing Group
    Nature genetics 38 (2006), S. 474-478 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Urolithiasis is one of the most common urologic diseases in industrialized societies. Calcium oxalate is the predominant component in 70–80% of kidney stones, and small changes in urinary oxalate concentration affect the risk of stone formation. SLC26A6 is an anion exchanger expressed on the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng1762
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  • 4
    Electronic Resource
    Electronic Resource
    Modifier role of internal H + in activating the Na + –H + exchanger in renal microvillus membrane vesicles (1982)
    [s.l.] : Nature Publishing Group
    Nature 299 (1982), S. 161-163 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Microvillus membrane vesicles were isolated from rabbit renal cortex by a modification10 of the Mg-aggregation method of Booth and Kenny11. For membranes prepared in this manner, the enrichment in specific activity (final pellet/homogenate) of luminal membrane markers, such as y-glutamyl ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/299161a0
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  • 5
    Electronic Resource
    Electronic Resource
    Properties of the Renal Na+-H+ Exchanger (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 456 (1985), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1985.tb14867.x
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  • 6
    Electronic Resource
    Electronic Resource
    Weak acid permeability of a villous membrane: Formic acid transport across rat proximal tubule (1994)
    Springer
    Bulletin of mathematical biology 56 (1994), S. 459-490 
    Details
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract Chloride/formate exchange, in parallel with Na+/H+ exchange and nonionic diffusion of H2CO2, has been proposed as a mechanism of electroneutral transcellular Cl− reabsorption by the proximal tubule. However, the measured brush border H2CO2 permeability of the rat proximal tubule is at least an order of magnitude too low to support sufficient H2CO2 recycling. To investigate the possibility that an unstirred layer within the brush border might depress the measured H2CO2 permeability, we constructed a mathematical model of a villous membrane. Axial fluxes along villous and intervillous spaces were specified by Nernst-Planck diffusion equations. Model parameters were set to achieve agreement with ion and water fluxes measured in the rat proximal tubule. The equations were solved numerically to generate steady-state concentration profiles in the villous and intervillous spaces. An apparent brush border H2CO2 permeability was determined by perturbing luminal [H2CO2] and calculating the change in H2CO2 flux. Overall, the ratio of apparent brush border H2CO2 permeability to cell membrane H2CO2 permeability was greater than 90%. Contributing to the small decrease in apparent permeability are finite diffusion coefficients, folding of the membrane, and acidification of the luminal solution. An approximate analysis of this system shows the critical parameters of brush border formate transport to be the actual membrane H2CO2 permeability, and the diffusion coefficients of HCO 3 − and HCO 3 − . Nevertheless, decreasing the diffusion coefficients by one order of magnitude failed to depress apparent brush border H2CO2 permeability by more than an additional 25%. We conclude that although permeability is systematically underestimated across a villous membrane, unstirred layer effects in the brush border are still too small to resolve the discrepancy between the measured value of H2CO2 permeability and the value needed to allow recycling.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02460467
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  • 7
    Electronic Resource
    Electronic Resource
    Renal and intestinal absorptive defects in mice lacking the NHE3 Na + /H + exchanger (1998)
    [s.l.] : Nature America Inc.
    Nature genetics 19 (1998), S. 282-285 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] NHE3 is one of five plasma membrane Na+/H+ exchangers and is encoded by the mouse gene Slc9a3 . It is expressed on apical membranes of renal proximal tubule and intestinal epithelial cells and is thought to play a major role in NaCl and HCO3– absorption. As the distribution of NHE3 ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/969
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  • 8
    Electronic Resource
    Electronic Resource
    Inhibition of Ca-activated K+ channels from renal microvillus membrane vesicles by amiloride analogs (1992)
    Springer
    The journal of membrane biology 128 (1992), S. 115-122 
    Details
    ISSN: 1432-1424
    Keywords: amiloride ; methylisobutyl amiloride ; ethylisopropyl amiloride ; Ca-activated K+ channels ; inhibition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary The effect of the K+-sparing diuretic amiloride and two of its hydrophobic analogs, methylisobutyl amiloride (MIA) and ethylisopropyl amiloride (EIPA), on Ca-activated K+ channels from renal microvillus membrane vesicles incorporated into planar lipid bilayers was investigated. Amiloride did not inhibit currents through Ca-activated K+ channels. MIA and EIPA, however, inhibited channel currents when added to both the internal and external solutions in concentrations between 10 and 250 μM. Furthermore, when dose-response data for channel inhibition were examined using Hill plots, Hill numbers of ≈ 1.5 were found for both blockers from both sides, suggesting that the mechanism of block involves multiple inhibitory binding sites. A simple kinetic scheme is proposed that can account for the results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00231884
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  • 9
    Electronic Resource
    Electronic Resource
    Substrate and inhibitor specificity of anion exchangers on the brush border membrane of rabbit ileum (1985)
    Springer
    The journal of membrane biology 88 (1985), S. 199-204 
    Details
    ISSN: 1432-1424
    Keywords: anion exchange ; Cl∶HCO3 exchange ; SO4∶OH exchange ; Ox∶Cl exchange ; brush border membrane ; ileum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary In previous studies we have found that several anions can be transported by an exchange process in rabbit ileal brush border membranes. We demonstrated exchanges of Cl for OH or HCO3, SO4 for OH, oxalate for OH, and oxalate for Cl. The purpose of these studies was to determine the number of distinct carriers mediating these exchanges. We utilized substrate and inhibitor specificity studies to distinguish between different anion exchange transporters. We conclude that SO4∶OH and oxalate: OH exchange occur on the same carrier because: (i) pH-gradient stimulated transport of both14C-oxalate and35SO4 were equally sensitive tocis-inhibition by unlabeled SO4 or oxalate; and (ii) both were inhibited equally by K. We conclude that oxalate: OH and oxalate: Cl exchanges occur on different carriers because: (i) Cl or SO4 caused unequalcis-inhibition of these two exchanges; and (ii) as compared to oxalate: Cl exchange, oxalate: OH exchange was more sensitive to inhibition by probenecid and K and less sensitive to inhibition by bumetanide. Finally, we conclude that oxalate: Cl exchange and Cl∶HCO3 exchange occur on different carriers because: (i) Cl∶HCO3 exchange was almost completely insensitive tocis-inhibition by oxalate; and (ii) oxalate: Cl exchange was more sensitive to inhibition by DIDS and bumetanide than Cl∶HCO3 exchange. Thus we have found that there are at least three separate anion exchangers on rabbit ileal brush border: (i) a Cl∶HCO3 exchanger; (ii) a SO4∶OH exchanger, which also transports oxalate; and (iii) an oxalate: Cl exchanger.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01868433
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  • 10
    Electronic Resource
    Electronic Resource
    Energy-dependence of phlorizin binding to isolated renal microvillus membranes (1978)
    Springer
    The journal of membrane biology 42 (1978), S. 81-98 
    Details
    ISSN: 1432-1424
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary In order to elucidate the mechanism by which the electrochemical Na+ gradient energizes glucose transport, the energy-dependence of high affinity phlorizin binding to isolated renal microvillus membrane vesicles was examined. Phlorizin is a competitive inhibitor of glucose transport but is not itself transported. Extravesicular Na+ accelerated the rate of phlorizin binding and inhibited the rate of dissociation of bound glycoside. Maneuvers to enhance intravesicular electronegativity stimulated phlorizin uptake and those to enhance intravesicular electropositivity inhibited. However, alterations in electrical potential were without effect on the rate of release of bound phlorizin. Intravesicular Na+ inhibited the phlorizin uptake rate. The results are consistent with a model of the glucose transporter in which (i) Na+ increases the binding affinity of the carrier, (ii) the free carrier is negatively charged, and (iii) the translocation of the carrier is inhibited by the binding of Na+ in the absence of sugar. The electrochemical Na+ gradient thus energizes both glucose transport and phlorizin binding through its effect on the affinity and appearance of, the free carrier at the membrane surface rather than through an effect on sugar translocation per se.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01870395
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