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  • 1
    Electronic Resource
    Electronic Resource
    Structure arising from the interaction of phospholipid micelles with headpiece-stalk sectors detached from the mitochondrial cristal membrane (1970)
    s.l. : American Chemical Society
    Biochemistry 9 (1970), S. 1318-1326 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00808a004
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  • 2
    Electronic Resource
    Electronic Resource
    EFFECT OF THE HYDROXYL RADICAL ON FIBROBLAST-MEDIATED COLLAGEN REMODELLING IN VITRO (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 23 (1996), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. It has been reported that free radicals prevent wound healing. However, the mechanism of this effect is not yet clear. We attempted to clarify the influence of hydroxyl radicals on wound healing in vitro.2. We used an ascorbate-copper ion system (ACS) to produce hydroxyl radicals in accordance with variables of time elapsed and concentration of copper ion. The effects of hydroxyl radical on fibroblast-mediated collagen remodelling, cell viability, the functions of fibroblasts and collagen fibrils were studied.3. With a copper ion concentration of 100μmol/L ACS significantly reduced contraction, while 10μmol/L stimulated contraction. Hydrogen peroxide (H2O2) was employed in observing these findings. ACS did not influence cell viability, the expression of α2β1 integrin and cellular fibronectin, or the cytoskeletal organization of fibroblasts involving actin until 3h. A concentration of ACS at 10μmol/L of copper ion induced the polymerization of collagen after 30 min, while ACS at 100 μmol/L induced collagen degradation; this finding was also established by using H2O2. Collagen reduced the amount of formaldehyde produced by trapping hydroxyl radical with dimethyl sulfoxide.4. Our findings suggest that collagen is denatured by scavenging the hydroxyl radical before fibroblasts are damaged, so that the radical may influence the remodelling of collagen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1996.tb02600.x
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  • 3
    Electronic Resource
    Electronic Resource
    Observations on the fine structure of interdigitating cell sarcoma (1989)
    Springer
    Virchows Archiv 414 (1989), S. 121-128 
    Details
    ISSN: 1432-2307
    Keywords: Interdigitating cell sarcoma ; Eosinophilic inclusion ; Electron microscopy Membrane complex
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In this histo-pathological follow-up study of a case of interdigitating cell sarcoma, intracytoplasmic membrane complexes were seen by electron microscopy within the neoplastic cells. These complexes might correspond to the eosinophilic inclusions seen in the tumour cells by light microscopy; they were not identified in the initial lymph node lesion. Recently, these structures have been found to be a variation of microtubuloreticular complexes. To our knowledge, they have not been previously described in interdigitating cell sarcoma. Their significance remains obscure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00718591
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  • 4
    Electronic Resource
    Electronic Resource
    Bronchiolitis obliterans in ataxia-telangiectasia (1997)
    Springer
    Virchows Archiv 430 (1997), S. 131-137 
    Details
    ISSN: 1432-2307
    Keywords: Bronchiolitis obliterans ; Ataxia-telangiectasia ; Mycoplasma ; MHC class II
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pulmonary disease was studied in four patients with ataxia-telangiectasia. Immunodeficiency was characterized by lymphopaenia, hypo-gammaglobulinaemia and decreased T -cell response to phytohaemagglutinin stimulation in mixed lymphocyte cultures. All four patients died from respiratory failure. Autopsy revealed that all four patients suffered from bronchiolitis obliterans in all lobes. Immunohistochemical examination demonstrated expression of MHC class II antigens on bronchiolar epithelium. Pulmonary infections in ataxia-telangiectasia patients included a case of mycoplasma pneumonia, one of cytomegalovirus pneumonia and one ofPseudomonas aeruginosa infection. The aetiology and immunological background of bronchiolitis obliterans are discussed. Bronchiolitis obliterans is a characteristic finding in ataxia-telangiectasia and may be due to the underlying immune deficit.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01008034
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  • 5
    Electronic Resource
    Electronic Resource
    Interdigitating cell sarcoma (ICS) (1989)
    Springer
    Virchows Archiv 415 (1989), S. 447-457 
    Details
    ISSN: 1432-2307
    Keywords: Interdigitating cell sarcoma ; Monoclonal antibodies ; Gene rearrangements ; Ki-1 antigen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Three independent mouse monoclonal antibodies (mAbs) ID1 (IgG3), ID2 and ID3 (IgM) were raised against whole cells of a surgically resected human interdigitating cell sarcoma (ICS). In immunoperoxidase staining, these mAbs strongly stained the cytoplasm of ICS neoplastic cells as well as interdigitating cells in normal lymphoid tissues. These mAbs also detected monocyte/ macrophages and dendritic cells, although their staining was highly variable depending on tissue distribution of the cells. Additional immuno-histological and enzyme histochemical study revealed that the neoplastic cells of ICS had cytoplasmic acid phosphatase and membranous alkaline phosphatase activity, and also possessed S100fβ protein, Ki-1 antigen, DAKO-macrophage antigen, and weak vimentin activity. Neither rearrangement of immunoglobulin heavy chain gene nor of T-cell receptor genes was detected in the DNA of ICS by Southern hybridization. These observations provide further confirmation of our previous finding (Nakamura et al. 1988, 1989) that the origin of ICS is interdigitating rather than lymphoid cell, and indicate that our mAbs could be useful as a cellular differentiation marker of interdigitating cells and for diagnosis of ICS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00747746
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  • 6
    Electronic Resource
    Electronic Resource
    The transverse tubular system of rat myocardium: its morphology and morphometry in the developing and adult animal (1986)
    Springer
    Anatomy and embryology 173 (1986), S. 307-315 
    Details
    ISSN: 1432-0568
    Keywords: Rat heart ; T system ; Morphology ; Morphometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The three dimensional arrangements of the T system in the developing and adult animal were investigated by means of high voltage electron microscope stereoscopy using Golgi treated materials. The rat myocardial T system was composed of three major group elements: the transverse tubules, longitudinal tubules and flattened cisternae, which were classified according to their orientation and to their morphological features. It was found, as the growth of the rats proceeded, that the longitudinal tubules increased creased in number and that the transverse tubules were arranged more regularly and densely at the level of the z-band. The flattened cisternae transiently increased in number during the 2–9 weeks, and then decreased gradually. Electron microscopy also revealed that all the transverse, longitudinal tubules and flattened cisternae of the T system had the chance of forming a coupling with the sarcoplasmic reticulum irrespective of its morphology and orientation to the myofibrils. Quantitative analysis of the rat T system from the stereo images indicated that the surface area (0.299 μm2/μm3) was considerably greater than previously reported.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00318914
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  • 7
    Electronic Resource
    Electronic Resource
    The effects of ultraviolet A and reactive oxygen species on the mRNA expression of 72-kDa type IV collagenase and its tissue inhibitor in cultured human dermal fibroblasts (1995)
    Springer
    Archives of dermatological research 288 (1995), S. 39-44 
    Details
    ISSN: 1432-069X
    Keywords: Key words UVA ; Reactive oxygen species ; MMP-2 ; TIMP-2 ; Fibroblasts
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of ultraviolet A (UVA) radiation and reactive oxygen species (ROS), generated with a xanthine and xanthine oxidase (XOD) system, on collagen enzymatic degradation involving the matrix metalloproteinase (MMP) and its tissue inhibitor of metalloproteinase (TIMP) were investigated using cultured human dermal fibroblasts. Total RNA was isolated and subjected to Northern blot analysis using cDNA clones for human interstitial collagenase (MMP-1), 72-kDa type IV collagenase (MMP-2) and TIMP-2. UVA irradiation resulted in an increase in MMP-1 mRNA up to 2.3-fold, but did not stimulate MMP-2 or TIMP-2 mRNA expression. In contrast, ROS induced by the xanthine and XOD system resulted in a dose-related increase in the level of MMP-2 mRNA up to 2.1-fold and a decrease in the level of TIMP-2 mRNA by 49% in the same fibroblasts. Catalase, used as scavenger, essentially prevented the ROS-induced alterations in MMP-2 and TIMP-2 mRNA levels. These results suggest that ROS produced in the dermis may contribute to biological changes in the connective tissue matrix observed in photoaging skin by accelerating the MMP-2-related matrix degradation system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030050020
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  • 8
    Electronic Resource
    Electronic Resource
    Immunohistochemical characteristics of chicken spleen ellipsoids using newly established monoclonal antibodies (1995)
    Springer
    Cell & tissue research 281 (1995), S. 135-141 
    Details
    ISSN: 1432-0878
    Keywords: Key words: Monoclonal antibody ; Reticular cell ; Ellipsoids ; Marginal zone ; Spleen ; Heat-shock protein ; Chicken
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Ellipsoids, the extra-vasculature sites surrounding penicilliary capillaries of the chicken spleen, play critical roles in the immune response and also in the clearance of pathogens or other particles. The meshwork of ellipsoids is formed by fibroblastic reticular cells. To characterize ellipsoidal reticular cells, a series of monoclonal antibodies against the chicken spleen have been developed. Of these antibodies, CSA-1 antibody reacts with fibroblastic reticular cells in ellipsoids and with endothelial cells. The reticular nature of positive cells in ellipsoids is indicated by immuno-electron microscopy, and by double-staining with anti-heat-shock protein 47 kDa (hsp47) antibody. The reaction of CSA-1 with reticular cells is limited in ellipsoids; CSA-1 does not react with reticular cells in other lymphoid organs. These findings indicate that ellipsoidal reticular cells share the antigen with endothelial cells. Ontogenic studies reveal that, on embryonic day 18, the development of ellipsoids is completed, penicilliary capillaries become fenestrated, and CSA-1 expression in ellipsoids begins. These findings suggest that CSA-1 is expressed on the cell surface of ellipsoidal reticular cells once they are exposed to blood flow.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00307967
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  • 9
    Electronic Resource
    Electronic Resource
    Immunohistochemical characteristics of chicken spleen ellipsoids using newly established monoclonal antibodies (1995)
    Springer
    Cell & tissue research 281 (1995), S. 135-141 
    Details
    ISSN: 1432-0878
    Keywords: Monoclonal antibody ; Reticular cell ; Ellipsoids ; Marginal zone ; Spleen ; Heat-shock protein ; Chicken
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Ellipsoids, the extra-vasculature sites surrounding penicilliary capillaries of the chicken spleen, play critical roles in the immune response and also in the clearance of pathogens or other particles. The meshwork of ellipsoids is formed by fibroblastic reticular cells. To characterize ellipsoidal reticular cells, a series of monoclonal antibodies against the chicken spleen have been developed. Of these antibodies, CSA-1 antibody reacts with fibroblastic reticular cells in ellipsoids and with endothelial cells. The reticular nature of positive cells in ellipsoids is indicated by immuno-electron microscopy, and by double-staining with anti-heat-shock protein 47 kDa (hsp47) antibody. The reaction of CSA-1 with reticular cells is limited in ellipsoids; CSA-1 does not react with reticular cells in other lymphoid organs. These findings indicate that ellipsoidal reticular cells share the antigen with endothelial cells. Ontogenic studies reveal that, on embryonic day 18, the development of ellipsoids is completed, penicilliary capillaries become fenestrated, and CSA-1 expression in ellipsoids begins. These findings suggest that CSA-1 is expressed on the cell surface of ellipsoidal reticular cells once they are exposed to blood flow.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00307967
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  • 10
    Electronic Resource
    Electronic Resource
    On the relationship between mitochondrial ATPase and the inner membrane (1973)
    Springer
    Journal of bioenergetics and biomembranes 4 (1973), S. 507-519 
    Details
    ISSN: 1573-6881
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Physics
    Notes: Abstract Digestion of the submitochondrial particle (ETPH) with a proteolytic enzyme, Nagarse, selectively and completely removed the headpieces from the membrane without damaging the electron transfer chain. By determining the amount of protein released by the Nagarse treatment, it was calculated that the headpieces represent 16±0.5% of the total protein of the submitochondrial particles. In respiring ETPH, membrane-bound AMP was found to be an acceptor of inorganic phosphate, and this esterification led to the formation of membrane-bound ADP. About 70% of the membranebound adenine nucleotides were found to be tightly bound to the intrinsic proteins of the membrane. A transphosphorylation reaction was observed between external and membrane-bound ADP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01515942
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