ISSN:
0006-3592
Keywords:
combinatorial library
;
polymer supported quench
;
4-thiazolidinones
;
Chemistry
;
Biochemistry and Biotechnology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Biology
,
Process Engineering, Biotechnology, Nutrition Technology
Notes:
A one-pot, three-component, solution-phase synthesis of 2,3-disubstituted and 2,3,5-trisubstituted 4-thiazolidinones is described. Poly(styrene-co-divinylbenzene)-supports functionalized with tris(2-aminoethyl)amine and 2-amino-ethanethiol are used to remove excess reagents from the desired product upon completion of the reaction. Simple filtration followed by concentration provides products of sufficient purity for biological evaluation. This approach has been used for a parallel combinatorial generation of a library of multi-substituted 4-thiazolidinones. © 1998 John Wiley & Sons, Inc. Biotechnol Bioeng (Comb Chem) 61:17-22, 1998.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
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