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  • 1
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The GLC1A locus for autosomal dominant primary open-angle glaucoma (POAG) with juvenile onset (before 20 years) has been mapped to chromosome 1q21– q31. Recently, a French-Canadian family was described in which both juvenile-onset and middle-age or early-onset POAG were observed and linked to GLC1A. We now describe a second POAG family with variable age of onset (range 11–51, median 36 years of age). Linkage to GLC1A was established with a maximum lod score of 6.21 at the D1S452 locus. A recombination event in a severely glaucomatous patient restricted the distal boundary of the GLC1A interval proximal to the AFM154xc9 marker. This study strengthens the idea that early-onset POAG may also be determined by the GLC1A genetic region.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Graefe's archive for clinical and experimental ophthalmology 232 (1994), S. 675-679 
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract • Background: The purpose of this study was to assess the role of arterial hypotension in the pathogenesis of certain types of glaucoma. • Methods: We compared diurnal and nocturnal fluctuations in blood pressure by using an ambulatory recording over a 24-h period in two different groups of patients: one of 16 patients with focal ischemic glaucoma (FIG) and another of 16 patients with primary open angle glaucoma (POAG). • Results: Inpatients with FIG, compared to those with POAG, we found: lower diastolic blood pressure (BP; 75.7 vs 82.5 mmHg, P 〈 0.05), systolic BP (121.7 vs 131.2 mmHg, P 〈 0.05) and mean BP (90.5 vs 101.5 mmHg, P 〈 0.05) over 24 h; lower diurnal diastolic BP (78.1 vs 85.5 mmHg, P 〈 0.05), and systolic BP (124.6 vs 134.2 mmHg, P 〈 0.05); greater nocturnal systolic BP variability (8.2% vs 6.2%, P 〈 0.05); and a greater percentage of diurnal low readings (14.53% vs 2.8%, P〈0.05), compared with the literature limits (101/61 mmHg). However, the number of nocturnal low readings was not different for either group. • Conclusion: It is important to detect arterial hypotension — one of the components of the vascular factor — during examination of a patient with normal-pressure glaucoma. This is one element in preserving the best possible perfusion of the optic nerve.
    Type of Medium: Electronic Resource
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