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  • 1
    Electronic Resource
    Electronic Resource
    Large-Conductance Cation Channels in the Envelope of Nuclei from Rat Cerebral Cortex (1997)
    Springer
    The journal of membrane biology 158 (1997), S. 159 -166 
    Details
    ISSN: 1432-1424
    Keywords: Key words: Nuclear ion channels — Cation channel — Cell nucleus — Patch clamp — Ion selectivity – Nuclear envelope
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract. Eucaryotic nuclei are surrounded by a double-membrane system enclosing a central cisterna which is continuous with the endoplasmic reticulum and serves as a calcium store for intracellular signaling. The envelope regulates protein and nucleic acid traffic between the nucleus and the cytoplasm via nuclear pores. These protein tunnels cross through both nuclear membranes and are permeable for large molecules. Surprisingly, patch clamp recordings from isolated nuclei of different cell species have revealed a high resistance of the envelope, enabling tight seals and the resolution of single ion channel activity. Here we present for the first time single-channel recordings from nuclei prepared from neuronal tissue. Nuclei isolated from rat cerebral cortex displayed spontaneous long-lasting large conductances in the nucleus-attached mode as well as in excised patches. The open times are in the range of seconds and channel activity increases with depolarization. The single-channel conductance in symmetrical K+ is 166 pS. The channels are selective for cations with P K/P Na= 2. They are neither permeable to, nor gated by Ca2+. Thus, neuronal tissue nuclei contain a large conductance ion channel selective for monovalent cations which may contribute to ionic homeostasis in the complex compartments surrounding these organelles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002329900253
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  • 2
    Electronic Resource
    Electronic Resource
    Function of methanofuran, tetrahydromethanopterin, and coenzyme F420 in Archaeoglobus fulgidus (1989)
    Springer
    Archives of microbiology 152 (1989), S. 362-368 
    Details
    ISSN: 1432-072X
    Keywords: Archaebacteria ; Thermophiles ; Archaeoglobus ; Sulfate-reducing bacteria ; F420 ; Methanofuran ; Tetrahydromethanopterin ; Carbon monoxide dehydrogenase ; Acetyl-CoA/carbon monoxide dehydrogenase pathway ; Citric acid cycle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Archaeoglobus fulgidus is an extremely thermophilic archaebacterium that can grow at the expense of lactate oxidation with sulfate to CO2 and H2S. The organism contains coenzyme F420, tetrahydromethanopterin, and methanofuran which are coenzymes previously thought to be unique for methanogenic bacteria. We report here that the bacterium contains methylenetetrahydromethanopterin: F420 oxidoreductase (20 U/mg), methenyltetrahydromethanopterin cyclohydrolase (0.9 U/mg), formyltetrahydromethanopterin: methanofuran formyltransferase (4.4 U/mg), and formylmethanofuran: benzyl viologen oxidoreductase (35 mU/mg). Besides these enzymes carbon monoxide: methyl viologen oxidoreductase (5 U/mg), pyruvate: methyl viologen oxidoreductase (0.7 U/mg), and membranebound lactate: dimethylnaphthoquinone oxidoreductase (0.1 U/mg) were found. 2-Oxoglutarate dehydrogenase, which is a key enzyme of the citric acid cycle, was not detectable. From the enzyme outfit it is concluded that in A. fulgidus lactate is oxidized to CO2 via a modified acetyl-CoA/carbon monoxide dehydrogenase pathway involving C1-intermediates otherwise only used by methanogenic bacteria.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00425174
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  • 3
    Electronic Resource
    Electronic Resource
    Outcome analysis of pyeloplasty in infants (2000)
    Springer
    Pediatric surgery international 16 (2000), S. 189-193 
    Details
    ISSN: 1437-9813
    Keywords: Key words Ureteropelvic junction obstruction ; Hydronephrosis ; Anderson-Hynes pyeloplasty
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The study examined the outcome of pyeloplasties done for decompensated ureteropelvic junction (UPJ) obstruction in infancy over a 13-year period. In a retrospective study, 186 children who underwent pyeloplasty in infancy were analysed with particular emphasis on the pre- and postoperative findings of 123I hippuran scintigraphy/diuretic renograms. The pre- and postoperative management is outlined in detail. The 186 patients underwent a total of 203 pyeloplasties during the period from January 1983 to 31 December 1996. Three children died; one required a nephrectomy. The postoperative scintigrapic results of 156 children (85%) done about 12 months after surgery were available for evaluation: 101 (64%) showed stable renal function and 43 (27%) revealed more than 5% improvement of renal function. In 12 cases (7%) renal function deteriorated after pyeloplasty by more than 5% compared to the pre-operative scintigram. It is concluded that pyeloplasty in infants is a low-risk procedure. The encouraging results of this series support early correction of UPJ obstruction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003830050720
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  • 4
    Electronic Resource
    Electronic Resource
    Evolutionary fixation of RNA editing (1996)
    [s.l.] : Nature Publishing Group
    Nature 383 (1996), S. 225-225 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR—Gene sequences encoded in the organellar genomes of many organisms are incompatible with function of the gene product. The 'errors' in the sequence are corrected after transcription of the gene by processes described by the term 'RNA editing'1. The persistence throughout evolution of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/383225a0
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  • 5
    Electronic Resource
    Electronic Resource
    γ-H2AX illuminates meiosis (2001)
    [s.l.] : Nature Publishing Group
    Nature genetics 27 (2001), S. 236-238 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] During meiosis, chromosome replication is followed by an extended prophase devoted to interhomolog interactions that culminate in formation of one or a few selectively placed chiasmata. Chiasmata correspond to crossovers at both DNA and structural levels, and provide the connections that permit ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/85781
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  • 6
    Electronic Resource
    Electronic Resource
    The importance of gravitational self-field effects in binary systems with compact objects. II. The “static two-body problem” and the attraction law in a post-post-Newtonian approximation of general relativity (1978)
    Springer
    General relativity and gravitation 9 (1978), S. 821-833 
    Details
    ISSN: 1572-9532
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The attraction force of two massive bodies connected by a rod is calculated in a post-post-Newtonian approximation. As far as we know this is the first calculation in such an order of approximation. Although the result already shows a complicated field-field interaction, we reproduce Newton's attraction forceM 1 M 2/R 2 as the leading term in powers of 1/R.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00760871
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  • 7
    Electronic Resource
    Electronic Resource
    Book review (1989)
    Springer
    General relativity and gravitation 21 (1989), S. 1197-1199 
    Details
    ISSN: 1572-9532
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00763463
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  • 8
    Electronic Resource
    Electronic Resource
    Some remarks concerning the equivalence principle of general relativity with respect to quantum mechanical one-particle state (1980)
    Springer
    General relativity and gravitation 12 (1980), S. 29-41 
    Details
    ISSN: 1572-9532
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We discuss a recent experiment with interfering neutron beams in the gravitational field of the earth, and show how the explanation of the interference pattern can be obtained by an application of the equivalence principle to the one-particle states. The calculation is carried out in the coordinate system where the gravitational field has been transformed away.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00756165
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  • 9
    Electronic Resource
    Electronic Resource
    The importance of gravitational self-field effects in binary systems with compact objects. I. The “static two-body problem” and the attraction law in a post-Newtonian approximation of general relativity (1978)
    Springer
    General relativity and gravitation 9 (1978), S. 809-820 
    Details
    ISSN: 1572-9532
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract As a first step toward a proper treatment of compact objects in binary systems the attraction force of two massive bodies connected by a rod is calculated in a post-Newtonian expansion. Contrary to a calculation by Weyl und Bach we start without specializing the internal structure of the bodies. We consider general anisotropic pressures and do not require axial symmetry for the bodies. We calculate the attraction force first in a post-Newtonian approximation and then (in paper II) we shall be concerned with the post-post-Newtonian approximation. In both approximations we obtain Newton's attraction forceM S1 M S2/R 2 plus terms of order 1/R 3 and higher, whereM S1,M S2 are the Schwarzschild masses of the bodies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00760870
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  • 10
    Electronic Resource
    Electronic Resource
    Structures in the large-scale distribution of galaxies with different luminosities (1991)
    Springer
    Astrophysics and space science 180 (1991), S. 47-58 
    Details
    ISSN: 1572-946X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The large-scale structures of volume-limites subsample sorted out from the CfA catalog have been analysed by percolation method. The result shows that the features in the distribution of galaxies with different luminosities are significantly different. Especially, the most luminous galaxies are likely to exhibit hierarchical clustering on a scale about 50h 50 −1 Mpc, and the least luminous galaxies in our subsamples show string-like or sheet-like character in their distribution. These results suggest that the large-scale distribution of galaxies consists of clusters or cluster cores of most luminous galaxies and the less luminous galaxies spread out from these cores with a string-like or sheet-like structure. This picture of the large-scale distribution consists with previous results from two-point correlation analysis and fractal analysis. The implication of these results has been discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00644228
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