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  • 1
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 214 (1967), S. 708-709 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Diphenyl sulphone 4 : 4'-di-isothiocyanate was supplied by Dr. R. N. Iyer, of the Medicinal Chemistry Division of this Institute. The compound is insoluble in water, acid or alkali. SCN--NCS The strain of Hymenolepis nana used in these investigations was obtained from the Wellcome Laboratories of ...
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 207 (1965), S. 1259-1260 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] REMARKABLY little nas been done to find an ideal cesticide, and the extract of male fern (Dryopteris filix-mas), which has been in use from medieval times, is still the drug of choice. Yet this and other drugs like quinacrine, dichlorophen, hexylresorcinol, arecoline, etc., are rather toxic and ...
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Computing 52 (1994), S. 269-279 
    ISSN: 1436-5057
    Keywords: 52.A30 ; 52.A10 ; Intersection radius ; prune-and-search ; algorithms ; complexity ; computational geometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Description / Table of Contents: Zusammenfassung Wir bezeichnen als Radius des Durchschnitts einer Menge vonn geometrischen Objekten imd-dimensionalen Euklidischen RaumE d Radius der kleinsten abgeschlossenen Hyperkugel, welche einen nichtleeren Durchschnitt mit allen Objekten besitzt. In der vorliegenden Arbeit beschreiben wir optimale Algorithmen zuer Bestimmung einiger solcher Radien. Zuerst stellen wir einen Algorithmus mit linearem Zeitbedarf vor, wenn die Objekte Hyperebenen inE d mit festemd sind. Er beruht auf der Reduktion des Problems auf eine (d+1)-dimensionale Lineare Optimierungsaufgabe mit 2n linearen Nebenbedingungen. Wir beschreiben auch die Lösung des Durchschnitts-Radius Problems fürn Strecken in der Ebene. Dazu benutzen wir neben Breitensuche die Ersetzung von Halbstrahlen durch Punkte oder Gerade. Bisher waren keine Algorithmen bekannt, welche diese Probleme in den gleichen Zeitschranken lösen.
    Notes: Abstract The intersection radius of a set ofn geometrical objects in ad-dimensional Euclidean space,E d , is the radius of the smallest closed hypersphere that intersects all the objects of the set. In this paper, we describe optimal algorithms for some intersection radius problems. We first present a linear-time algorithm to determine the smallest closed hypersphere that intersects a set of hyperplanes inE d , assumingd to be a fixed parameter. This is done by reducing the problem to a linear programming problem in a (d+1)-dimensional space, involving 2n linear constraints. We also show how the prune-and-search technique, coupled with the strategy of replacing a ray by a point or a line can be used to solve, in linear time, the intersection radius problem for a set ofn line segments in the plane. Currently, no algorithms are known that solve these intersection radius problems within the same time bounds.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-2072
    Keywords: Apomorphine ; Gnaw compulsion ; Cocaine ; Dopaminergic mechanism ; Mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Apomorphine (10 mg/kg, s.c.) does not induce in mice a compulsion to gnaw, but pretreatment with cocaine (10–40 mg/kg, i.p.) caused gnawing activity. This effect of cocaine was inhibited by pretreatment with α-methyl-p-tyrosine, haloperidol, and physostigmine, but not with FLA-63, phenoxybenzamine and tetrabenazine. These findings would suggest that dopaminergic mechanism plays a significant role in the potentiation of apomorphine gnawing activity by cocaine and also support the view that inhibition of dopamine uptake is responsible for the stimulatory action of cocaine.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-2072
    Keywords: Apomorphine ; Gnaw compulsion ; Antihistamines ; Cholinergic mechanism ; Methysergide ; p-Chlorophenylalanine ; Catecholaminergic mechanism ; Mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In mice, apomorphine (10 mg/kg s.c.) does not induce a compulsion to gnaw, but pretreatment with antihistamines, viz. pheniramine, chlorpheniramine and mepyramine, in doses ranging from 30 to 60 mg/kg i.p. caused gnawing activity. Mepyramine showed significantly less effect when compared to the other two agents. Antihistamines are known to influence the activity of biogenic amines in central nervous system. The potentiation of apomorphine-induced gnawing by antihistamines might depend upon the reciprocal balance between dopaminergic and cholinergic systems. This was tested by blocking biosynthesis of biogenic amines or by blocking their receptors. The potentiation of gnawing was antagonised by physostigmine (0.25 mg/kg) or blocked by pretreatment with α-methyl-p-tyrosine (α-MPT) (4×5 mg/kg) and bis-(4-methyl-1-homopiperazinyl-thiocarbonyl)-disulphide (FLA) (40 mg/kg), while p-chlorophenyl alanine (p-CPA) (3×100 mg/kg) had no effect. Similarly, phenoxybenzamine (30 mg/kg) and haloperidol (1.0 mg/kg) inhibited gnawing activity, but methysergide (10 mg/kg) had no effect. Furthermore, pretreatment with tetrabenazine (20 mg/kg) and l-Dopa (200 mg/kg) did not affect gnawing activity. It is concluded that both pheniramine and chlorpheniramine potentiate apomorphine gnawing by upsetting the cholinergic and dopaminergic balance in favour of dopaminergic dominance.
    Type of Medium: Electronic Resource
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