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  • 1
    Electronic Resource
    Electronic Resource
    Threshold Differentiation of Drive and Reward in the Olds Effect (1962)
    [s.l.] : Nature Publishing Group
    Nature 196 (1962), S. 699-700 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1. Hesults of preliminary experiment on one animal. Crosses show the number of lever presses to extinction in successive 30-sec periods of normal extinction. Circles represent the number of lever presses in 30 sec of extinction during which a low intensity of repetitive stimulation was given, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/196699a0
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  • 2
    Electronic Resource
    Electronic Resource
    Measuring the urban policy environment - An exploratory analysis using rent controls
    Amsterdam : Elsevier
    Habitat International 17 (1993), S. 39-52 
    Details
    ISSN: 0197-3975
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Geography , Sociology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0197-3975(93)90003-U
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  • 3
    Electronic Resource
    Electronic Resource
    Gamma-interferon production in cow milk allergy (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 48 (1993), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The aim of this study was to develop an assay to assist in the diagnosis of delayed onset of adverse responses to cow milk in children, by measurement of gamma-interferon (GIFN) produced in vitro in response to β-lactoglobulin-stimulated blood mononuclear cells. Diagnostic procedures identified 75 children with immediate reactions who had high total IeE and IgE-isotype responses to cow milk, 17 children who developed reactions after 24 h and had low total IgE and low IgE-isotype response to cow milk and 59 milk-tolerant children. GIFN production was less in children with immediate reactions compared to those with late reactions (P≤0.009) or milk-tolerant children (P=0.022). The results of this study suggest enhanced T-cell reactivity may be involved in the immuno-pathogenesis of non-immediate cow milk allergy, but GIFN production was not a clinically useful diagnostic test.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1993.tb00689.x
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  • 4
    Electronic Resource
    Electronic Resource
    Absence of continuous epitopes in the house dust mite major allergens Der p I from Dermatophagoides pteronyssinus and Der f I from Dermatophagoides farinae (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 26 (1996), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background The house dust mite has been shown to be an important source of domestic allergens associated with immediate hypersensitivities. The Group I mite allergens Der p I from Dermatophagoides pteronyssinus and Der f I from D. farinae display extensive amino acid sequence homology and have similarities with cysteine protease enzymes.Objective The availability of the complete amino acid sequences for these allergens allowed us to search for the allergic detertninants within these molecules. The aim of the present investigation was to identify any continuous IgE-binding epitopes within these amino acid sequences. We also sought to test the validity of previously reported Der p I peptide epitope sequences.Methods In order to identity any continuous IgE epitopes, the amino acid sequences of Der p I and Der f I were synthesized as decapeptides overlapping in sequence and coupled to plastic pins. The specific IgE-binding capacity of these peptides was assayed using an enzyme-linked biotin-streptavidin procedure and sera from patients known to be sensitive to these allergens. Previously reported Der p I peptide epitopes were synthesized as free peptides and tested for their ability to inhibit specific IgE binding to allergen extract discs.Results None of the pin-coupled Der p I or Der f I peptides was found by the continuous epitope mapping procedure to bind significantly to specific IgE in the sera of hypersensitive patients. The previously reported Der p I peptide epitopes did not inhibit specific IgE binding to mite extract discs.Conclusion The specific IgE binding epitopes of the house dust mite allergens Der p I and Der f I are discontinuous in nature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1996.tb00054.x
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  • 5
    Electronic Resource
    Electronic Resource
    A major continuous allergenic epitope of bovine β-lactoglobulin recognized by human IgE binding (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 24 (1994), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Hexapeptides of sequential overlapping sequences of β-lactoglobulin (BLG) were used to probe scrum from children with immediate-type cow milk allergy for IgE binding to continuous epilopes of BLG in an enhanced enzyme-linked immunosorbent assay (ELISA). Six regions of IgE binding were identified on the BLG molecule and these were synthesized as dodecapeptides. Inhibition of IgE binding to whole BLG was used to confirm the BLG-specific binding of IgE to each of the synthesized peptides. One of the peptides. peptide 4, showed inhibition in an IgE anti-BLG radioimmunoassay to all 16 sera tested. The patterns of inhibition with the native BLG molecule and peptide 4 were significantly correlated (P =0.005). suggesting that this peptide contains a major continuous IgE binding epitope of BLG.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1994.tb00987.x
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  • 6
    Electronic Resource
    Electronic Resource
    Natural history of cows' milk allergy in children: immunological outcome over 2 years (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 23 (1993), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In this investigation 98 children (median age 24 months) with cows' milk allergy (CMA) were studied over a median period of 2 years to see whether acquisition of clinical tolerance to cows' milk was associated with the changes in levels of IgG and IgE anti-cows' milk antibodies, and skin test reactivity to a cows' milk extract. Two groups of CMA patients were examined. The first were IgE sensitized and responded rapidly to small volumes of cows' milk with urticaria, and/or exacerbations of eczema, and/or wheeze, and/or vomiting (n= 69). The second, a late reacting group (n= 29) demonstrated coughing, diarrhoea, eczematoid rashes, and/or a combination of these which developed more than 20 hr after commencing normal volumes of cows' milk. Significant immunological changes were confined to the 69 IgE sensitized immediate-reacting-group of patients. Of these, there were 15 children who achieved clinical tolerance to cows' milk and they showed a significant fall in the levels of skin test reactivity to cows' milk over the study period (P 〈0.01). In addition, these 15 children had lower serum IgE antibodies to cows' milk proteins both at the outset and the final follow-up compared with the 54 patients whose CMA persisted. No consistent change in the IgG antibody responses to cows' milk proteins was seen in either group of patients over the study period. The findings suggest patients with immediate type hypersensitivity to cows' milk proteins whose disease persists for more than 2 years have a more severe dysregulation of IgE synthesis to cows' milk proteins from the outset. The role of humoral immune mechanisms in the pathogenesis of late reacting CMA remains unclear.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1993.tb00307.x
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  • 7
    Electronic Resource
    Electronic Resource
    Calcium-dependent phosphorylation processes control brain aromatase in quail (2003)
    Oxford, UK : Blackwell Science, Ltd
    European journal of neuroscience 17 (2003), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Increased gene transcription activated by the binding of sex steroids to their cognate receptors is one important way in which oestrogen synthase (aromatase) activity is regulated in the brain. This control mechanism is relatively slow (hours to days) but recent data indicate that aromatase activity in quail preoptic-hypothalamic homogenates is also rapidly (within minutes) affected by exposure to conditions that enhance Ca2+-dependent protein phosphorylation. We demonstrate here that Ca2+-dependent phosphorylations controlled by the activity of multiple protein kinases including PKC, and possibly also PKA and CAMK, can rapidly down-regulate aromatase activity in brain homogenates. These phosphorylations directly affect the aromatase molecule itself. Western blotting experiments on aromatase purified by immunoprecipitation reveal the presence on the enzyme of phosphorylated serine, threonine and tyrosine residues in concentrations that are increased by phosphorylating conditions. Cloning and sequencing of the quail aromatase identified a 1541-bp open reading frame that encodes a predicted 490-amino-acid protein containing all the functional domains that have been previously described in the mammalian and avian aromatase. Fifteen predicted consensus phosphorylation sites were identified in this sequence, but only two of these (threonine 455 and 486) match the consensus sequences corresponding to the protein kinases that were shown to affect aromatase activity during the pharmacological experiments (i.e. PKC and PKA). This suggests that the phosphorylation of one or both of these residues represents the mechanism underlying, at least in part, the rapid changes in aromatase activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1460-9568.2003.02598.x
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  • 8
    Electronic Resource
    Electronic Resource
    3D PRESTACK DEPTH MIGRATION IN THE GULF OF SUEZ: A CASE HISTORY (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Geophysical prospecting 40 (1992), S. 0 
    Details
    ISSN: 1365-2478
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences , Physics
    Notes: Seismic reflection data in the southern Gulf of Suez, offshore Egypt, are commonly severely affected by shallow velocity inhomogeneities in the form of diapiric salt bodies, and depth migration techniques must be used in order to image the presalt structure correctly. Frequently the diapir and the underlying prospective structure are three dimensional rather than two dimensional and thus require 3D techniques to resolve them. In addition, the severity of the problem is sometimes such that the common midpoint (CMP) stack assumptions are invalid and prestack depth migration is therefore required.In 1990, Unocal developed a practical 3D prestack depth-migration scheme, which was applied to a data set in the Gulf of Suez. The prospect was subsequently drilled and results proved the effectiveness of the technique.This paper describes the use of the technique in the form of a case history. It is expected that the technique will be routinely used to solve similar problems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2478.1992.tb00533.x
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  • 9
    Electronic Resource
    Electronic Resource
    The analysis of tocopherols in corn oil and bacon fat by thin-layer chromatography and spot density measurement (1978)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of food science & technology 13 (1978), S. 0 
    Details
    ISSN: 1365-2621
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: The two major tocopherols (α and γ forms) present in corn oil were separated, after removal of interfering lipids, by thin-layer chromatography (TLC), and detected on the TLC plate by spraying with Gibbs' reagent (2,6-dichloro-p-benzoquinone-4-chlorimine). Quantitation was achieved by densitometric scanning of the coloured spots, using a calibration curve prepared from reference samples of the pure α- and γ-tocopherols. α-tocopherol, added to bacon fat, was quantitatively recovered without measurable loss during the analysis. Other antioxidants commonly added to foodstuffs, with the exception of BHA and BHT, were not extracted. The method described has a detection limit of 20 ppm of α- or γ-tocopherol for a given fat sample, hence permits the quantitation of either tocopherol in vitamin E-rich materials, such as vegetable oils, but lacks the sensitivity to detect the trace amounts of tocopherols normally present in animal fatty tissues.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1978.tb00823.x
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  • 10
    Electronic Resource
    Electronic Resource
    Studies in the Drying Oils (1933)
    s.l. : American Chemical Society
    Industrial & engineering chemistry 25 (1933), S. 1086-1091 
    Details
    ISSN: 1520-5045
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ie50286a007
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