ISSN:
1434-9949
Keywords:
Corticoid-Induced Osteopenia
;
Sodium Fluoride
;
Vitamin D
;
Osteocalcin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Osteopenia observed in corticotherapy is due, among other causes, to a decrease in bone formation as can be shown by a steroid-induced osteocalcin decrease. Although various treatments have been proposed there is no agreement as to which one is the best. Two such treatments, sodium fluoride and vitamin D administration increase osteocalcin levels. We treated a group of 12 patients under corticoid therapy (mean dose 16 mg per day) with 50 mg/day p.o. sodium fluoride, and determined osteocalcin levels before and two weeks after sodium fluoride treatment. Similarly, another group of 9 patients with a similar mean steroid dose was treated with 0.5 μ/day of 1α(OH)2D3 in order to assess the effect of this vitamin on osteocalcin and to determine which was the best treatment. Both groups were compared with respective control groups. A significant osteocalcin increase was observed in the control groups (p〈0.001); similar significance was observed in the sodium fluoride group, whereas a lower significance (p〈0.01) was observed in the vitamin D group. These results suggest that sodium fluoride could be more effective than vitamin D in the treatment of steroid-induced osteopenia.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02208025
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