ISSN:
0947-3440
Schlagwort(e):
Supramolecular complexes
;
Amino acids
;
Autointramolecular blocking
;
Carbonic anhydrase
;
Activation
;
Macrocyclic ligands
;
Amino acids
;
Chemistry
;
Organic Chemistry
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Chemie und Pharmazie
Notizen:
The preparation of a series of supramolecular complexes of the ammonium salt of 2,3,11,12-bis[4-(10-aminodecylcarbonyl)]benzo-18-crown-6 with different natural and non-natural amino acids is reported. In all these ditopic supramolecular complexes, with the exception of the histidine derivative, the ammonium moiety of the amino acid is anchored by means of hydrogen bonds within the macrocyclic cavity of the host, whilst the carboxylate moiety interacts with the ammonium group of the derivatized crown ether. The new complexes act as very efficient activators of the zinc enzyme carbonic anhydrase (isozymes I and II).
Zusätzliches Material:
1 Ill.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1002/jlac.199719970908
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