ISSN:
1432-2013
Keywords:
Dehydration
;
Glomerular Filtration Rate
;
Isolated Kidney
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The two kidneys of one dog were perfused separately with the same blood pool and at a constant arterial pressure. After the control periods, one of the kidneys was replaced by another one taken from a dehydrated dog. The presence of the “dehydrated” kidney resulted in significant and almost immediate decreases of creatinin clearance, urine flow and sodium excretion by the contralateral kidney, without any change in the overall renal blood flow. These changes disappeared, after the removal of the “dehydrated” kidney. They were not observed if the “dehydrated” kidney was replaced either by a kidney taken from a salt-depleted, non water-deprived dog, or by a simple arterio-venous shunt. These results suggest that in the status of dehydration, the kidney releases some humoral material which might be responsible for the decrease of the measured GFR (C creat) perhaps by the way of permeability changes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00585851
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