ISSN:
1432-0738
Keywords:
n-Hexane
;
Pulmonary changes
;
Rabbits
;
Clara cells
;
Papillary tumors
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract New Zealand male rabbits were exposed in an inhalation chamber to 3,000 ppm of n-hexane 8 h/day, 5 days/week for 24 weeks, resulting in a total of 120 exposures. After a further 120 days in clean air, morphologic examination of lungs by light and transmission electron microscopy (TEM) revealed three important exposure-related lesions. These consisted of air space enlargement centered on respiratory bronchioles and alveolar ducts (centriacinar emphysema), scattered foci of pulmonary fibrosis, and papillary tumors of non-ciliated bronchiolar epithelial cells. At TEM examination these tumors were rather homogeneous and were found to consist of cells showing both small and large electron dense ovoid granules in their cytoplasmic matrix, a feature that has been described for Clara cells. The implications of these findings are discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00341015
Permalink
