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  • 1
    Electronic Resource
    Electronic Resource
    SUMMARY OF THE WORKSHOP ON PERINATAL AND POSTNATAL DEFECTS AND NEUROLOGIC ABNORMALITIES FROM CHEMICAL EXPOSURES (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 320 (1979), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1979.tb56627.x
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  • 2
    Electronic Resource
    Electronic Resource
    Mutation of a gene encoding a putative chaperonin causes McKusick-Kaufman syndrome (2000)
    [s.l.] : Nature America Inc.
    Nature genetics 25 (2000), S. 79-82 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] McKusick-Kaufman syndrome (MKKS, MIM 236700) is a human developmental anomaly syndrome comprising hydrometrocolpos (HMC), postaxial polydactyly (PAP) and congenital heart disease (CHD). MKKS has been mapped in the Old Order Amish population to 20p12, between D20S162 and D20S894 (ref. 3). Here we ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/75637
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  • 3
    Electronic Resource
    Electronic Resource
    Prenatal growth in the albino rat: Effects of number, intrauterine position and resorptionsSupported by N.I.H. grants HDT-141 and HD-630. (1970)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 128 (1970), S. 413-427 
    Details
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Data from 103 litters of albino rats were analyzed for the effects of the number of fetuses in the litter and in each uterine horn, resorptions, and intra-uterine position on variations in fetal weight. The right uterine horn tended to contain more fetuses than the left. There appeared to be systemic control over both the number of fetuses in the litter and their distribution between the horns. The number of fetuses per litter and the number per horn had separate and different effects on fetal weight. The number of fetuses in the horn was a more important determinant of fetal weight than was the number in the litter. Fetal weight was higher and the effect of the number of fetuses in the horn was stronger in horns with early resorptions than in horns without resorptions. Resorptions had no effect on the weight of adjacent fetuses or on fetal weight variation in the horn which suggests that resorptions influence fetal growth systemically rather than locally. Fetal mortality was highest in the lower one-third of the uterine horn and lowest in the upper one-third. Fetal weight variation increased as the number of fetuses per horn increased and as mean fetal weight decreased. Intrauterine position was a significant determinant of fetal weight. The heaviest fetuses occupied the middle of the uterine horn while the lightest fetuses were at either end. The importance of these findings in prenatal growth and teratologic studies is discussed.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1001280403
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  • 4
    Electronic Resource
    Electronic Resource
    The litter effect as a variable in teratologic studies of the albino ratSupported by NIH grants HD 630 and T1-141. (1970)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 128 (1970), S. 185-191 
    Details
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: This study was conducted to determine if there is a greater variation in fetal weight and/or placental weight among litters of rat fetuses than within a single litter. Three hundred and twenty-seven litters comprising 1,979 fetal and placental weights were analyzed using analysis of variance within versus among litters. There was a definite litter effect, i.e., variation in fetal and placental weight was greater (p 〈 0.05) among litters than within litters. The variation in fetal and placental weights between litters became greater with increasing litter size. Experimentally limiting the litter size early in gestation does not reduce or eliminate the litter effect. This litter effect means that individual fetuses from several rat pregnancies cannot be considered to have come from a common universe and, therefore, the number of litters and their mean growth data are much more meaningful than the number of embryos in an experiment. When designing research programs in which embryonic and placental growth in rats are to be evaluated, it is more important to establish the experimental goal on the basis of the total number of litters rather than the total number of embryos per experimental or control group.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1001280205
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