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Digitale Medien

Study of deterioration in long-term treatment of parkinsonism with L-Dopa plus decarboxylase inhibitor (1976)

Ludin, H. P. ; Bass-Verrey, F.

Springer

Journal of neural transmission 38 (1976), S. 249-258

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Details

ISSN: 1435-1463

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary 35 parkinsonian patients have been treated over 3 years with L-Dopa combined with benserazide. After an impressive improvement during the first months of treatment a slow but significant deterioration of the patients' condition was observed. At the end of the observation period however their condition was still significantly better than before starting the treatment. A reduced mean L-Dopa dosage was ruled out as the cause of this deterioration. Withdrawal of the L-Dopa therapy for a few days in 13 patients provided strong evidence that it is due to the progression of the disease and to a partial loss of L-Dopa efficacy.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01249442

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