ISSN:
1573-8280
Schlagwort(e):
cancer immunotherapy
;
natural interleukin 2
;
suppressor cells
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Abstract Lymphocyte-derived, natural, glycosylated interleukin 2 (IL 2) may have different effectsin vivo than the non-glycosylated recombinant IL 2 hitherto employed in clinical trials. To test this, 9 tumor patients were given 3–6 × 106 U/day natural IL 2 by continuous infusion for 5 days. Compared with previously published results obtained using recombinant IL 2, as far as similar tests were performed, no unexpected results were obtained with natural IL 2 in the present study. Plasma TNF-α levels increased considerably during therapy, IFN-γ very slightly, whereas IL 2-stimulated secretion of either cytokinein vitro fluctuated greatly. CD 16+ and CD25+ cells increased and CD45R+ cells decreased after treatment, consistent with significant lymphocyte activationin vivo. MHC-unrestricted cytotoxicity increased after treatment. The level of CD8+ cells was and remained within the normal range, although suppressive activity generated in mixed lymphocyte culture was deficient prior to therapy. Interestingly, this normalised after therapy. These results extend studies of immunological monitoring of patients receiving IL 2, based on the first trial using natural rather than recombinant IL 2.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF02221323
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