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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 155 (1996), S. 1015-1017 
    ISSN: 1432-1076
    Keywords: Key words Castleman disease ; Microcytic anaemia ; Childhood
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We describe the case history of a 13-year-old girl with chronic fatigue and prolonged microcytic anaemia. She received oral iron since the age of 11 but failed to respond to it. Laboratory studies revealed elevated C-reactive protein and hypergammaglobulinaemia. A large solitary mesenterial lymph node could be demonstrated by ultrasonography and CT. A diagnosis of Castleman disease was suspected and confirmed histologically. After surgical removal of the lymphoma the patient recovered completely. Conclusion Castleman disease should be considered in cases of chronic fatigue, unexplained fever, microcytic anaemia and hypergammaglobulinaemia.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1076
    Keywords: Key words Tuberous sclerosis complex ; TSC2 gene ; Loss of heterozygosity ; Pancreas ; Islet cell tumour
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 12-year-old boy with tuberous sclerosis complex (TSC) presented with a large retroperitoneal tumour. Exploratory surgery revealed an infiltrative tumour originating from the pancreas, with local metastases to the lymph nodes. The histologal diagnosis was a malignant islet cell tumour. Retrospectively measured pancreatic hormone levels, however, were normal. A connection between the malignancy and TSC was demonstrated by loss of heterozygosity of the TSC2 gene in the tumour. The primary mutation Q478X in this patient was identified in exon 13 of the TSC2 gene on chromosome 16. Conclusion Pancreatic islet cell tumours have been mainly associated with multiple endocrine neoplasia syndrome type 1. In our case we demonstrate a direct relationship of this tumour to tuberous sclerosis complex, in the absence of further signs of multiple endocrine neoplasia syndrome type 1.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 149 (1990), S. 534-535 
    ISSN: 1432-1076
    Keywords: Premature thelarche ; Cimetidine ; H2 receptor blocker
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An 18-month-old girl is reported in whom marked unilateral breast enlargement occurred after 4 weeks of cimetidine therapy. After withdrawal of the drug the enlargement rapidly disappeared. This observation points to cimetidine as a possible cause of premature thelarche. Cimetidine, a selective H2 receptor blocking agent, is known to cause gynaecomastia in males. This effect seems related to clevated plasma oestrogens, gonadotropins, or to binding of the drug to androgen receptors. Ranitidine, a much more potent selective H2 receptor blocker, does not cause gynaecomastia and seems therefore preferable to cimetidine.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Pediatric surgery international 10 (1995), S. 226-228 
    ISSN: 1437-9813
    Keywords: Laparoscopy ; Children ; Duhamel-Martin procedure ; Hirschsprung's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Five consecutive infants had a laparoscopic Duhamel-Martin procedure without colostomy for Hirschsprung's disease. No major problems occured, but the procedures were long-lasting, requiring postoperative intensive care for 1 night in four of teh five patients. In on patient the procedure was converted to an open one, as the quality of the anastomosis was doubtful. It is concluded that the Duhammel-Martin procedure can be carried out safely in a one-stage operation in young infants using a laparoscopic approach.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Pediatric surgery international 5 (1990), S. 165-169 
    ISSN: 1437-9813
    Keywords: Chest wall ; Pectus excavatum ; Pectus carinatum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The hypothesis that bilateral subperichondral removal of several costal cartilages, as is carried out during the operative correction of anterior chest wall deformities, might interfere with chest wall growth in growing individuals was investigated in an experimental study. Kittens were operated upon at 4 months of age and killed 8 months later. Fifteen animals formed the experimental group and 7 the control group. Chest radiographs were taken under standardized conditions preoperatively and monthly postoperatively until death at 12 months of age. The radiological width and depth of the thorax was measured at the level of the 1sst and 10th thoracic vertebrae. The groups behaved similarly in terms of growth in length and weight gain. The depth of the thorax at the 1 st and 10th thoracic vertebrae and the width at the 10th thoracic vertebra were significantly smaller in the experimental group (P ⩽ 0.001). The differences were already maximal at the first postoperative check and persisted throughout the follow-up period. It is concluded that although bilateral subperichondral removal of several costal cartilages in 4-month-old kittens causes collapse of the anterior chest wall, it does not interfere with chest wall growth. Since the bony ribs comprise a much larger part of the antero-posterior diameter of the chest wall in children than in kittens, it is argued that collapse of the anterior chest wall after a similar operation is much less likely to occur in children.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Pediatric surgery international 8 (1993), S. 447-448 
    ISSN: 1437-9813
    Keywords: Hirschsprung's disease ; Duhamel procedure ; Stapling device
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The EndoGIA 30(V) is a new stapling device that has become commercially available for laparoscopic surgery. An alternative use is the side-to-side colorectal anastomosis in the Duhamel-Martin procedure for Hirschsprung's disease. The authors' experience with the first 12 patients has been such that we plan to continue to use this device in the treatment of Hirschsprung's disease.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1437-9813
    Keywords: Bladder exstrophy ; Covered exstrophy ; Exstrophy variant ; Pseudoexstrophy ; Anorectal malformation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report the case of a male newborn with covered bladder exstrophy, high anorectal malformation, and rectourethral fistula. The child had a split symphysis and diverging rectus muscles in the infraumbilical region. The ventral part of the bladder was covered with thin, fragile skin and some portions of the bladder bulged out as abdominal-wall hernias. Two of these hernias were located just above the penis, and the overlying skin showed a resemblance to scrotal skin. The penis was small and slightly laterally displaced, but otherwise normal; the child also had unilateral reflux into a dysplastic left kidney. The bladder neck and posterior urethra were patulous, but there was no urinary incontinence. The child underwent a singlestage reconstruction of the exstrophic lesion and a staged repair of the anorectal malformation. The clinical significance of this entity is discussed and the literature reviewed.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Pediatric surgery international 9 (1994), S. 334-337 
    ISSN: 1437-9813
    Keywords: Gastroesophageal reflux ; Antireflux procedure ; Nissen fundoplication ; Thal fundoplication ; Complications
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The Nissen fundoplication has been the most commonly used procedure in the surgical management of reflux esophagitis. Due to unsatisfactory results and the many complications of the Nissen procedure, in 1989 we began using the Thal partial wrap. In a retrospective study, the results from both procedures are compared. Between August 1982 and May 1991, antireflux operations (27 Nissen; 23 Thal) were performed in 44 children. Fifty-eight percent had associated conditions, neurological impairment (12) and esophageal atresia being the most frequent. An uneventfull postoperative course was seen in 29.6% after the Nissen fundoplication and 87% in the Thal group (P 〈0.5). Recurrence or persistence of gastroesophageal reflux was observed in 37% and 4% of the Nissen and Thal groups, respectively. The symptom-free interval following the antireflux procedure averaged 11 months in the Nissen group and 2.8 months in the Thal group. Three out of 4 neurologically impaired children with a Nissen fundoplication had postoperative complications compared to 2 out of 8 with a Thal partial wrap. Eight children, all with a Nissen fundoplication, had to be reoperated for either acute obstruction or a redo procedure. The mean hospitalization times for the Nissen and Thal procedures were 16 and 7.6 days, respectively (P 〈0.1). From our experience, the Thal partial fundoplication appears to be an effective antireflux procedure with fewer perioperative complications than the Nissen operation. In the neurologically impaired child with feeding problems and reflux, a Thal fundoplication in combination with a gastrostomy is our therapy of choice.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Pediatric surgery international 9 (1994), S. 483-485 
    ISSN: 1437-9813
    Keywords: Jejunal replacement of esophagus ; Jejunal interposition ; Long-gap esophageal atresia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Since 1988, four children with long-gap esophageal atresia have undergone one-stage orthotopic jejunal pedicle-graft interposition at the age of 2 to 3 months. Obtaining enough jejunal length was no problem and major early complications did not occur. In one patient stenosis of the distal anastomosis was problematic and required corrective surgery. None of the patients demonstrated jejunitis as a result of gastroesophageal reflux. With follow-up periods of 12, 27, 46, and 60 months, all patients are doing well. It is concluded that the jejunum is a better esophageal substitute than is generally appreciated.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Surgical endoscopy and other interventional techniques 10 (1996), S. 863-864 
    ISSN: 1432-2218
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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