ISSN:
1432-1211
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Mutantt haplotypes derived from thet 6 haplotype were typed forH-2. The mutantt h2 that arose fromt 6 due to crossing over in the region betweenT andtf had, as expected, lost theH-2 haplotype characteristic oft 6. The haplotypest h17,t h18, andt p1, which also arose by recombination, but which represent the complementary crossover products, including the distal part of thet 6 haplotype, carried the sameH-2 type ast 6. This suggests that crossing over betweentf andH-2 is suppressed int h17 andt 18. This in turn suggests that mutantt haplotypes suppress crossing over for that part of thet chromatin that they still retain. The origin oft h7, which apparently did not include any crossover distal toT, and which retains the crossover-suppressing property oft 6, retains thet 6 H-2 type. Unexpectedly, J h20 , which expressestf and was at first thought to have arisen due to crossing over, also retains theH-2 type oft 6. This provides part of the evidence thatt h20 arises fromt 6 not by crossing over, but by a small deletion, and hence that duplication and deletion are possible modes of origin of mutantt haplotypes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01563947
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