ISSN:
1432-2072
Keywords:
Anorectics
;
Ingestion rate
;
Microstructure of ingestion
;
Food intake
;
Sugars
;
Carbohydrate
;
Amphetamine
;
Fenfluramine
;
Fluoxetine
;
Phenylpropanolamine
;
Serotonin
;
Norepinephrine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The serotonergic agonists fenfluramine and fluoxetine and the catecholaminergic agonists amphetamine and phenylpropanolamine are well known to cause a reduction in intake in rats. In the studies reported here we investigated the effects of these drugs on the microstructure of licking behavior of the rat ingesting 0.4 M sucrose. The purpose was to examine the similarities in the behavioral effects within and between these two classes of anorectic agents. The serotonergic agonists fenfluramine and fluoxetine caused a reduction in intake primarily by reducing the size of bursts and clusters of licking within the test meal without affecting the duration of the meal, suggesting a reduction in the palatability of the test solution. The catecholamine agonists amphetamine and phenylpropanolamine reduced intake primarily by reducing the number of bursts and clusters without affecting their size, suggesting a fractionation in the organization of the normal pattern of ingestion. The differences between the two serotonin and the two catecholamine agonists on the microstructure of the licking behavior suggest a different effect of the two neurotransmitters on the motor system that controls ingestive behavior. The similarities between the two different agonists within each class suggests a common neurotransmitter mechanism responsible for these two different effects on the behavior of the animals.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02247717
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