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  • 1
    Electronic Resource
    Electronic Resource
    Genomic organization and chromosomal localization of mouse proteinase 3 (Myeloblastin) (1999)
    Springer
    Mammalian genome 10 (1999), S. 210-212 
    Details
    ISSN: 1432-1777
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Proteinase 3 (PR3), is a matrix-degrading serine proteinase expressed in different hematopoietic cell lineages. The PR3 protein appears to regulate the myeloid differentiation and was found to be the autoantigen associated with Wegener granulomatosis. We have isolated and characterized the gene for mouse PR3 (mPR3) and determined its chromosomal location. The gene has been localized to Chromosome (Chr) 10. Comparison of mouse PR3 genomic structure with that of its human counterpart indicates that: 1) the mPR3 gene spans 7 kb organized in 5 exons and 4 introns, 2) the codons of His-Asp-Ser of the catalytic site are conserved and spread out over different exons, similar to the human gene, and 3) the gene product encodes a pre-proform of the protein. Knowledge of the structure and chromosomal location of the mPR3 gene may help better the understanding of the temporal and cell-specific expression of mouse PR3.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003359900974
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Characterization of the mouse neutrophil elastase gene and localization to Chromosome 10 (1997)
    Springer
    Mammalian genome 8 (1997), S. 5 -8 
    Details
    ISSN: 1432-1777
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Neutrophil elastase (NE), a serine proteinase, is considered to play a role in normal tissue turnover and host defense. NE may also cause tissue damage in acute and chronic inflammatory diseases. We have isolated and characterized the gene for mouse NE and determined its chromosomal location. The mouse NE gene has been localized by interspecific backcross analysis to Chromosome (Chr) 10. The gene for mouse NE is composed of 5 exons and 4 introns, similar to the human NE. Mouse NE shares the highly conserved exon size and intron-exon borders with human NE. The coding exons of the mouse NE gene predict a translation product in a pre-pro form, similar to human NE. Knowledge of the genomic organization and chromosomal location of mouse NE may allow us to further define mechanisms responsible for cell and tissue-specific expression of mouse NE.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003359900337
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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