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Structure and function of the CD94 C-type lectin receptor complex involved in recognition of HLA class I molecules (1997)

López-Botet, Miguel ; Pérez-Villar, Juan J. ; Carretero, Marta ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

Immunological reviews 155 (1997), S. 0

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ISSN: 1600-065X

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Summary: A multigene family of immunoglobulin superfamily (Ig-SF) killer cell inhibitory receptors (KIRs) specifically recognize HLA class I molecules, while the interaction with H-2 products is mediated by members of the murine Ly49 C-type lectin family. A common structural feature of these receptors with inhibitory function is the presence of cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that couple them to SHP phosphatases. Strong support for the involvement of the CD94 C-type lectin receptor complex in NK cell-mediated recognition of Bw6+ HLA-B, HLA A and HLA-C alleles has been obtained. The cloned CD94 molecule covalently assembles with at least two different glyco-proteins (43 kDa and 39 kDa) to form functional receptors. NK cells inhibited upon HLA recognition express the CD94/p43 dimer, whose specificity for HLA molecules partially overlaps the Ig-SF receptor system. By contrast. NK clones bearing the homologous CD94/p39 receptor are triggered upon its ligation by CD94-specific mAbs. Remarkably, a set of Ig-SF receptors (p50) homologous to p58 KIRs also display an activating function. CD94-associated molecules belong to the NKG2 family of C-type lectins; the NKG2-A gene encodes for the p43 subunit. which contains cytoplasmic ITIMS. Expression of the different CD94 heterodimeric receptors will enable precise analysis of their putative interaction with HLA class I molecules.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1600-065X.1997.tb00949.x

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Structure of the human CD94 C-type lectin gene (1998)

Rodríguez, Antonio ; Carretero, Marta ; Glienke, Jens ; [et al.]

Springer

Immunogenetics 47 (1998), S. 305-309

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ISSN: 1432-1211

Keywords: Key words CD94 ; Gene ; NK cell ; C-type lectin ; Chromosome 12

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Abstract The genomic structure of the human CD94 gene was obtained by analyzing genomic clones obtained from two different libraries. The CD94 gene contains six exons separated by five introns. The carbohydrate-recognition domain (CRD) is encoded by three exons, and the conservation of intron positions within the CRD indicated that CD94 is closely related to group V of C-type lectins. Primer extension and S1 nuclease protection assays showed that initiation of transcription in the CD94 gene is heterogeneous, but restricted to a 60 base pair region around the major initiation site enclosed within a putative initiator element (TTA+1TTCA). The study of the promoter region of CD94 may help to understand the selective expression of this C-type lectin glycoprotein on NK cells and subsets of cytotoxic T cells.