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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Diabetologia 7 (1971), S. 156-159 
    ISSN: 1432-0428
    Keywords: Glucose tolerance ; diurnal ; diabetes ; animal ; epidemiology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Des études du test de tolérance au glucose oral, effectué à 9 h et à 14 h ont montré une variation diurne de la tolérance au glucose chez des lapins et des rats normaux. On a également constaté des réponses variables similaires chez un petit nombre de volontaires. Les animaux intolérants aux hydrates de carbone, diffèrent des animaux normaux par le fait que l'on n'observe pas chez eux de variation diurne de la réponse à une charge orale constante en glucose.
    Abstract: Zusammenfassung Untersuchungen der oralen Glucose-Toleranz, die um 9 h und 14 h durchgeführt wurden, zeigten eine von der Tageszeit abhängige Variation bei normalen Kaninchen und Ratten. Bei einer kleinen Anzahl von freiwilligen Versuchspersonen ließen sich ähnliche Unterschiede feststellen. Tiere, die intolerant gegenüber Kohlenhydraten waren, unterschieden sich von normalen Tieren dadurch, daß bei Belastungen am Morgen und am Nachmittag keine Differenzen bei konstanter oraler Glucosebelastung zu beobachten waren.
    Notes: Summary Studies of the oral glucose tolerance test performed at 0900 h and 1400 h have shown a diurnal variation of glucose tolerance in normal rabbits and rats. Similar variable responses in a small series of volunteers have also been demonstrated. Carbohydrate-intolerant animals differ from the normal animals studied in that no morning and afternoon variation of response to a constant oral glucose challenge has been observed.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 2 (1970), S. 155-160 
    ISSN: 1432-1041
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Taloximine is a phthalazine derivative with a respiratory stimulant action on the peripheral chemoreceptors. Peak plasma levels of taloximine after oral administration coincided with peak hyperventilation accompanied by a respiratory alkalosis, a, fall in venous pCO2, and a rise in plasma and urinary pH. — Taloximine was excreted in urine and bile. Metabolites included a phthalazinone, demethylated taloximine and other metabolites in ring hydroxylated form. Sulphated and glucuronated taloximine and metabolites were formed.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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