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  • 1
    Electronic Resource
    Electronic Resource
    The effects of proglumide on morphine induced motility changes (1984)
    Springer
    Psychopharmacology 84 (1984), S. 541-543 
    Details
    ISSN: 1432-2072
    Keywords: Morphine ; Cholecystokinin ; Proglumide ; Locomotion ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Proglumide (0.02 mg/kg), a cholecystokinin antagonist, was administered to rats either together with or without morphine (0, 5, 15, or 45 mg/kg). Whereas proglumide in the absence of morphine showed a trend towards enhanced behavioral activation, it potentiated the hy[okinesia induced by morphine. These results are consistent with the hypothesis that endogenous cholecystokinin tonically antagonizes opiate modulation of motility, irrespective of whether such modulation is produced by opiates and endogenous or exogenous origin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431463
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