ISSN:
1432-1335
Keywords:
Prostate
;
Rat
;
Electron microscope
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The prostate epithelium of rats which received repeated cadmium chloride (CdCl2) injections showed a gradual disruption of structural differentiation. Electron microscopy studies revealed severe changes in the ultrastructure affecting all epithelial cell organelles, particularly the nuclei, rough endoplasmatic reticulum, the golgi apparatus, and mitochondria. The cells infiltrating the stroma contained secretory vacuoles and their nuclear evaginations on the invasion front showed similarities to ultrastructural pathological changes in man. Examination of the ventral prostate following oral CdCl2 administration revealed changes ranging in severity up to dysplasia, but there was no evidence of carcinoma.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00405833
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