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  • 1
    Electronic Resource
    Electronic Resource
    A “Minimal Signal-Stepwise Activation” Analysis of Functional Maturation of T Lymphocytes (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Immunological reviews 111 (1989), S. 0 
    Details
    ISSN: 1600-065X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-065X.1989.tb00541.x
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  • 2
    Electronic Resource
    Electronic Resource
    Therapy of focal and segmental glomerulosclerosis with methylprednisolone, cyclosporine A, and prednisone (1998)
    Springer
    Pediatric nephrology 12 (1998), S. 397-400 
    Details
    ISSN: 1432-198X
    Keywords: Key words: Nephrotic syndrome ; Focal segmental glomerulosclerosis ; Treatment ; Prednisone ; Cyclosporine A
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Patients with steroid-resistant focal and segmental glomerulosclerosis (FSGS) have a poor prognosis but may benefit from high-dose methylprednisolone or cyclosporine A therapy. Ten patients were treated with a protocol of methylprednisolone infusions for 8 weeks followed by a combination of cyclosporine A and alternate-day prednisone for maintenance of remission for 2 weeks. Eight of ten patients remitted the nephrotic syndrome within 8 weeks of beginning treatment. One patient remitted edema but remained proteinuric, and one did not respond. After observation for 12 – 24 months, seven patients maintained remission with normal glomerular filtration rate. One non-responder had renal insufficiency and one patient had secondary non-response and end-stage renal disease. No patients developed hypertension. One patient had the diagnosis of Hodgkin disease made after 10 months of therapy. Follow-up renal biopsy in four patients showed no evidence of progressive interstitial disease. There were no other major side effects. Steroid-resistant FSGS may be successfully treated with the described protocol. Additional studies will be needed to determine if this approach prevents progression of renal disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004670050473
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  • 3
    Electronic Resource
    Electronic Resource
    The effect of recombinant human growth hormone on responses to alloantigens in the pediatric transplant patient (1996)
    Springer
    Pediatric nephrology 10 (1996), S. 280-282 
    Details
    ISSN: 1432-198X
    Keywords: Key words: Growth hormone ; Transplantation ; Mixed leukocyte culture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Recombinant human growth hormone (rhGH) improves growth in children after renal transplantation, but may be associated with augmented immune responses. We previously demonstrated that rhGH augments proliferative and cytotoxic responses and interferon-gamma (IFN-γ) mRNA expression during a mixed leukocyte culture (MLC). In this study, we evaluated 12 pediatric patients after receiving a renal allograft from one of their parents. Peripheral blood mononuclear cells (PBMC) were isolated from patients and cultured with either donor or unrelated third-party PBMC in an MLC. Patients developed significant donor-specific hyporesponsiveness (DSH), however, no correlation was seen between the amount of DSH and graft function. Of the 12 patients, 2 developed augmented responses in the presence of rhGH. rhGH augments proliferation, cytotoxicity, and IFN-γ expression during an MLC. Some patients develop increased responses to donor-specific alloantigens after renal transplantation. Further study is needed to better determine the significance of this finding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00866759
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  • 4
    Electronic Resource
    Electronic Resource
    The effect of recombinant human growth hormone on responses to alloantigens in the pediatric transplant patient (1996)
    Springer
    Pediatric nephrology 10 (1996), S. 280-282 
    Details
    ISSN: 1432-198X
    Keywords: Growth hormone ; Transplantation ; Mixed leukocyte culture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Recombinant human growth hormone (rhGH) improves growth in children after renal transplantation, but may be associated with augmented immune responses. We previously demonstrated that rhGH augments proliferative and cytotoxic responses and interferon-gamma (IFN-γ) mRNA expression during a mixed leukocyte culture (MLC). In this study, we evaluated 12 pediatric patients after receiving a renal allograft from one of their parents. Peripheral blood mononuclear cells (PBMC) were isolated from patients and cultured with either donor or unrelated third-party PBMC in an MLC. Patients developed significant donor-specific hyporesponsiveness (DSH), however, no correlation was seen between the amount of DSH and graft function. Of the 12 patients, 2 developed augmented responses in the presence of rhGH. rhGH augments proliferation, cytotoxicity, and IFN-γ expression during an MLC. Some patients develop increased responses to donorspecific alloantigens after renal transplantation. Further study is needed to better determine the significance of this finding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00866759
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Methylprednisolone treatment of patients with steroid-resistant nephrotic syndrome (1992)
    Springer
    Pediatric nephrology 6 (1992), S. 503-505 
    Details
    ISSN: 1432-198X
    Keywords: Nephrotic syndrome ; Methylprednisolone ; Alkylating agent
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Treatment with a combination of pulse methylprednisolone (MP) and an alkylating agent has been reported to induce long-term remission of proteinuria in patients with steroid-resistant nephrotic syndrome (SRNS). We have treated 13 patients with SRNS with a course of pulse MP. There were 8 black patients and 5 white; 10 had a biopsy diagnosis of focal segmental glomerulosclerosis (FSGS) and 3 nil lesion. Initially 5 patients responded and 2 partially responded. Of the responding patients, 5 relapsed while treated with alternate-week MP therapy. Of these relapsing patients, 3 received a second course of MP plus chlorambucil; 2 responded. The patients were observed for a mean of 47 months (range 4–64 months). When last seen only the 3 patients with a biopsy diagnosis of nil lesion were protein free. There were no complications of steroid therapy. Six patients currently have end-stage renal disease and 2 have renal insufficiency. All of the 6 patients with no response to treatment were black. These data suggest that a course of pulse MP therapy alone induces short-term remission of the nephrotic syndrome in some white patients with FSGS, but in almost no blacks. Patients who relapse may respond to retreatment, but addition of an alkylating agent does not appear to induce longterm remission in patients with FSGS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00866483
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Treatment of IgA nephropathy in children: efficacy of alternate-day oral prednisone (1993)
    Springer
    Pediatric nephrology 7 (1993), S. 529-532 
    Details
    ISSN: 1432-198X
    Keywords: IgA nephropathy ; Treatment ; Prednisone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have previously reported our experience with the use of alternate-day prednisone in the treatment of 6 patients with IgA nephropathy who have clinical or pathological risk factors for disease progression. We have now treated a total of 13 patients and followed them from 4 to 10 years. Patients received an alternate-morning dose of prednisone for 2–4 years. Dosage began at 60 mg/m2 for 3 month, was reduced to 30 mg/m2 by 1 year and 15 mg/m2 by 2 years. At last observation, urinary protein excretion was normal in 12 patients and no patient had hematuria. Twelve patients had normal estimated glomerular filtration rate (GFR) and one had renal insufficiency (GFR=38 ml/min per 1.73 m2). A renal biopsy was performed in 11 patients after 2 years of treatment. Activity score decreased from 5.2 to 4.3 (P=0.03) and chronicity score increased from 2.2 to 2.8 (P=0.12). There were no complications of treatment. When compared with a historical group, the treated patients had a significant improvement in urinalysis (P〈0.00001) and preservation of normal GFR (P=0.03). We conclude that alternate-day prednisone therapy may benefit patients with IgA nephropathy. A large prospective controlled trial is needed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00852535
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    Paper (German National Licenses)
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