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  • 1
    Electronic Resource
    Electronic Resource
    Protection of sea urchin embryos against the action of some neuropharmacological agents and some detergents by endogenous gangliosides (1975)
    Springer
    Cellular and molecular life sciences 31 (1975), S. 902-904 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Выводы Чувствтельность ранних змбионов морских ежей к змбриотоксическим нейрофармалогическим препаратам и дергентам резко снижается при повьшении концентрации змбрионов. Зтот зффект, ро-видиому, обусловлен выдением в инкуационную среду ганглиозидов из змбриональыых клеток. При испытании зашитного действия фракций ганглиозидов, выделенных из змбрионов морских ежей, наиболее зффективными антидота ми против нейрофармакологических прераратов была гематозидоподобная фракция и против детегентов —фракция моносиалоганглиозидов.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02358841
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  • 2
    Electronic Resource
    Electronic Resource
    Gangliosides and antitumor immunity (1993)
    Springer
    Journal of molecular medicine 71 (1993), S. 590-594 
    Details
    ISSN: 1432-1440
    Keywords: Gangliosides ; Natural killer cells ; T-suppressors ; Antitumor immunity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To elucidate the possible influence on the host's immune defense of ciruclating gangliosides released from tumor cells, the effects of exogeneous gangliosides on the activities of some lymphocyte subpopulations were examined. The mono- and disialyllactosylceramides GM3 and GD3, which frequently are present in elevated amounts in sera of tumor-bearing hosts, were found to inhibit strongly the cytotoxicity of natural killer cells, to stimulate T-suppressor activity of peripheral blood lymphocytes, and to inhibit their phytohemagglutinin-induced blast transformation. All these effects may be linked to the ability of gangliosides to modulate the arachidonic acid cascade in lymphoid cells, which for the first time was demonstrated in the course of our studies. Possible mechanisms underlying the immunomodulatory effects of serum gangliosides as well as their role in the escape of tumor cells from immune surveillance and inhibition of the hosts immune system are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00184480
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  • 3
    Electronic Resource
    Electronic Resource
    The interaction of prostaglandins with human serum lipoproteins (1989)
    Springer
    Bioscience reports 9 (1989), S. 27-40 
    Details
    ISSN: 1573-4935
    Keywords: prostaglandins ; serum lipoproteins ; cholesterol homeostasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Using high density and low density lipoproteins (HDL and LDL) labeled with fluorescent analogues of phosphatidylcholine or sphingomyelin it was found that low amounts (10−12 M) of prostaglandins E1 and F2α induced different structural rearrangements of the lipoprotein surface, whereas prostaglandins E2 and F1α had no effect. The effects of prostaglandin E1 on HDL were largely paralled by those of this prostaglandin on synthetic recombinants prepared from pure apolipoprotein A1, phospholipids and cholesterol and were demonstrated to be caused by prostaglandin-apolipoprotein interaction. The interaction resembled that of a ligand with a specific receptor protein because it was specific, reversible, concentration and temperature dependent and saturable. However the retaining capacity of HDL or LDL for prostaglandin E1 as determined by equilibrium dialysis was very low and a single prostaglandin E1 molecule was able to induce structural changes in large numbers of discrete lipoprotein particles. To explain this remarkable fact a non-equilibrium model of ligand-receptor interaction is proposed. According to that model in open systems characterized by weak ligand-receptor binding, high diffusion rate of the ligand and long relaxation times which exceed the interval between two successive receptor occupations, the ligand-induced changes will accumulate, resulting in transformation of the system into a new state which may be far away from equilibrium. It is emphasized that the low mobility of lipids constituting the environment of the receptor protein plays a critcal role in this type of signal amplification. It was further demonstrated that the PGE1-induced changes of the lipoprotein surface resulted in an enhancement of LDL-to-HDL transfer of cholesterol esters and phosphatidylcholine especially in the presence of serum lipid transfer proteins. The acceleration of the interlipoprotein transfer caused by prostaglandin E1 in turn increases the rate of cholesterol esterification in serum. It is suggested that in such a way prostaglandin E1 may influence the homeostasis of cholesterol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01117509
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  • 4
    Electronic Resource
    Electronic Resource
    Synthesis of steroid compounds and related substances Communication XVII. Preparation ofa,β-unsaturated cyclic ketones (2-cycloalken-1-ones) (1953)
    Springer
    Russian chemical bulletin 2 (1953), S. 787-798 
    Details
    ISSN: 1573-9171
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary 1. A general method has been developed for the preparation ofa,β-unsaturated cyclic ketones. There are two stages: bromination of a cyclic ketone in presence of calcium or magnesium carbonate; and elimination of hydrogen bromide from the bromo ketone formed, which is effected by heating it in presence of diethylaniline. 2. 2-Methyl-2-cyclohexen-1-one (58% yield), 2-methyl-2-cyclopenten-1-one (50% yield), 2-cyclohexen-1-one (35% yield), and 2-cyclopentea-1-one (25% yield) have been prepared by this method. 3. It has been proved that, in the bromination of 2-methylpyclohexanone and of 2-methylcyclopentanone, bromine attacks the tertiary carbon atom, and not a secondary carbon, as assured previously by some workers. 4. The method of preparing 2,4-dimethyl-2-cyclopenten-1-one has been simplified and improved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01178858
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  • 5
    Electronic Resource
    Electronic Resource
    Quantitative thin-layer chromatography of ether extractable serum lipids in some disorders of fat metabolism (1969)
    Springer
    Chromatographia 2 (1969), S. 246-250 
    Details
    ISSN: 1612-1112
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Die Zusammensetzung der mit Äther extrahierbaren menschlichen Serumlipoide normaler Personen und atherosklerotischer, diabetischer, hyperlipämischer und an Ikterus leidenden Patienten wurden mit quantitativer Dünnschicht-Chromatographie untersucht. Es konnte festgestellt werden, daß, obwohl der Äther in jedem Fall nur einen Teil des Lipoidgehaltes der Serumbeta-Lipoproteide extrahiert, die Lipoidzusammensetzung des Ätherextraktes für jede der erwähnten Lipoidstoffwechselstörungen charakteristisch ist. Die außergewöhnliche Extrahierbarkeit der Lipoiden bei einem positiven Jirgl-Test aufweisenden Ikterus ist auf den außerordentlich hohen Phosphatidgehalt der atypischen beta-Lipoproteide des Serums zurückzuführen. Die Komplexbildung der Serum beta-Lipoproteide mit Dextransulfat schwächt in der selben Weise ihre Struktur und ermöglicht das Extrahieren der neutralen Lipoide mit Äther.
    Abstract: Sommaire La composition des lipides du sérum humain extractible par éther chez des personnes normaux et des malades souffrant d'athérosclérose, de diabète, hyperlipémie et ictère a été examiné par chromatographie sur couche mince. On a trouvé que dans chacun des cas l'éther n'extrait que partiellement la teneur en lipoide des beta-lipoproteines du sérum, la composition des lipoides de l'extrait étheral étant charactéristique pour tous les disordres du métabolisme de lipoides mentionné cihaut. L'extractibilité extraordinaire des lipoides en cas d'ictère à test positif de Jirgl est dû à la teneur extrême en phosphatide des beta-lipoproteines atypiques du sérum. La fromation des complexes de béta-lipoproteines du sérum avec du dextran-sulfate affaibli leur structure d'une manière analogue permentant l'extraction des lipoides neutres par l'éther.
    Notes: Summary The composition of ether extractable human serum lipids in normal persons and in patients suffering from atherosclerosis, diabetes hyperlipemia and jaundice was investigated by quantitative thin-layer chromatography. It was found that in all cases ether only partially extracts the lipid moiety of the serum beta-lipoproteins, the lipid composition of the ethereal extract being characteristic of each of the above lipid metabolism disorders. The unusual extractability of lipids in jaundice with a positive Jirgl-test is caused by the extremely high phosphatide content of the atypical beta-lipoproteins in the serum. The formation of complexes of serum beta-lipoproteins with dextran sulfate weakens their structure in a similar way, making the neutral lipids extractable by ether.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02268884
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  • 6
    Electronic Resource
    Electronic Resource
    S15.1 Gangliosides as risk factors in atherosclerosis (1993)
    Springer
    Glycoconjugate journal 10 (1993), S. 311-312 
    Details
    ISSN: 1573-4986
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01210087
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  • 7
    Electronic Resource
    Electronic Resource
    Neuere Methoden der präparativen organischen Chemie IV. Synthese natürlich vorkommender Fettsäuren durch sterisch kontrollierte Carbonyl-OlefinierungDie Beiträge der vorangehenden Reihen I-III sind in drei Bänden im Verlag Chemie, Weinheim/Bergstr., erschienen. (1964)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 76 (1964), S. 113-123 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Es wird gezeigt, daß die Carbonyl-Olefinierung (Reaktion von Carbonyl-Verbindungen mit Phosphorylenen) sterisch kontrolliert werden kann. In vielen Fällen läßt sich durch die Wahl der Reaktionsbedingungen eine cis-Olefinierung erreichen; die trans-Olefinierung hängt von der Struktur der Olefine ab. Mit Hilfe dieser Reaktionen lassen sich ungesättigte und polyungesättigte Fettsäuren mit unterschiedlicher Lage und Aufeinanderfolge von cis-und trans-Doppelbindungen sowie ω-Hydroxy- und verzweigte Fettsäuren stereospezifisch synthetisieren.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19640760302
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  • 8
    Electronic Resource
    Electronic Resource
    Neue Methoden. Eine neue Fettsäuresynthese (1962)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 74 (1962), S. 41-41 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19620740165
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  • 9
    Electronic Resource
    Electronic Resource
    Synthesis of Naturally Occurring Unsaturated Fatty Acids by Sterically Controlled Carbonyl Olefination (1964)
    Weinheim : Wiley-Blackwell
    Angewandte Chemie International Edition in English 3 (1964), S. 250-260 
    Details
    ISSN: 0570-0833
    Keywords: Unsaturated fatty acids ; Fatty acids ; Carbonyl olefination ; Synthetic methods ; Wittig reactions ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: It is shown that carbonyl olefination, i.e. the reaction of carbonyl compounds with alkylidene phosphoranes, can be sterically controlled. In some cases cis-olefins can be obtained by proper choice of the reaction conditions; trans-olefins are formed only in the presence of suitable structural factors. These cis-and trans-olefination reactions have opened new, stereo-specific routes to unsaturated and polyunsaturated fatty acids with differing positions and sequences of cis- and trans-double bonds and to ω-hydroxy and branched chain fatty acids.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/anie.196402501
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