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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 567 (1989), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 599 (1990), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Chronic non-communicable diseases (CNCDs) are reaching epidemic proportions worldwide. These diseases — which include cardiovascular conditions (mainly heart disease and stroke), some cancers, chronic respiratory conditions and type 2 diabetes — affect people of all ages, ...
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SAPKs/JNKs are activated by the phosphorylation of tyrosine and threonine residues, which is catalysed by the dual-specificity kinase Sekl (MKK4 or JNKK)7"9. To examine the function of the Sekl-regulated stress signalling pathway, we generated mouse ES cell lines lacking sekl expression by using ...
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Postsynaptic targeting of the Drosophila tumour suppressor discs-large (Dlg) critically depends on its SH3 and GK domains. Here, we asked whether these domains are also involved in subcellular targeting of the mammalian Dlg homolog SAP97 and its interacting partners in CNS cortical neurons by analysing a recently described mouse mutant lacking the SH3 and GK domains of SAP97. Both wildtype and truncated SAP97 were predominantly expressed in perinuclear regions, in a pattern suggesting association with the endoplasmic reticulum. Weaker immunoreactivity was found in neurites colocalizing with both dendritic and axonal markers. As SAP97 has been implicated in the early intracellular processing of the glutamate receptor GluR1, we studied biochemical maturation and subcellular localization of GluR1 in the mutants. Both the glycosylation pattern and synaptic clustering of GluR1 were indistinguishable from wildtype mice. Synaptic clustering of the guanylate kinase domain interacting protein GKAP was also intact. Our data demonstrate that truncation of the SH3 and GK domains of SAP97 in mice does neither change its subcellular distribution nor does it disrupt synaptic structure or protein clustering, as opposed to severe missorting of the respective mutant Dlg protein in Drosophila.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1540-8183
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: BERNSTEIN, A.D., et al.: The NASPE/BPEG Defibrillator Code. A new generic code, patterned after and compatible with the NASPE/BPEG Generic Pacemaker Code (NBG Code) was adopted by the NASPE Board of Trustees on January 23, 1993. It was developed by the NASPE Mode Code Committee, including members of the North American Society of Pacing and Electrophysiology (NASPE) and the British Pacing and Electrophysiology Group (BPEG). It is abbreviated as the NBD (for NASPE/BPEG Defibrillator) Code. It is intended for describing the capabilities and operation of implanted cardioverter defibrillators (ICDs) in conversation, record keeping, and device labeling, and incorporates four positions designating: (1) shock location; (2) antitachycardia pacing location; (3) means of tachycardia detection; and (4) antibradycardia pacing location. An additional Short Form, intended only for use in conversation, was defined as a concise means of distinguishing devices capable of shock alone, shock plus antibradycardia pacing, and shock plus antitachycardia and antibradycardia pacing. (PACE, Vol. 16, September 1993)
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Futura Publishing, Inc.
    Pacing and clinical electrophysiology 24 (2001), S. 0 
    ISSN: 1540-8159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Bernstein, A.D., et al.: Survey of Cardiac Pacing and Implanted Defibrillator Practice Patterns in the United States in 1997. A survey of implanters of permanent cardiac pacemakers and ICDs in the United States during 1997 was conducted to identify present and changing patterns in indications for pacing, implantation techniques, pacing-mode selection, follow-up, and opinions regarding pacing and ICD related issues. This report is an update from 1993 of surveys performed every 4 years for the International Cardiac Pacing and Electrophysiology Society (ICPES). Questionnaires were sent to implanting physicians who were members of the North American Society of Pacing and Electrophysiology (NASPE), and who might, therefore, be expected to be more conversant than others with the state of the art. Four major manufacturers also provided estimates of the numbers of pacemakers and ICDs implanted in the United States from 1994 through 1997. In 1997, approximately 182,000 new rhythm management devices, including 153,000 primary pacing systems and 29,000 ICDs, were implanted, an increase of 24% for pacemakers and 90% for ICDs since 1994. In 1997, pacemaker implantations were performed by about 8,600 physicians working in 3,300 hospitals and 1,000 independent “surgi-centers.” From 1994 to 1997, sales in the United States of dual chamber pacemakers rose from 58% to 69% of the total, and adaptive rate systems from 74% to 90%. ICD sales increased by about 29% per year from 18,700 to 35,000 units. This study disclosed significant differences among implanter subcategories and between present and earlier practices, and it provided useful insights into trends in pacemaker and defibrillator practice. Future surveys would be facilitated if a standardized implant registry like that used in Europe were established in the United States.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Pacing and clinical electrophysiology 23 (2000), S. 0 
    ISSN: 1540-8159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Since 1994, 611 patients with atrial Accufix leads have been followed. Consideration was given to explanting these leads based on the presence or absence of fractures of the retention wire. All leads were followed according to a protocol proposed by the manufacturer, chiefly by regular 6-month high quality X rays and fluoroscopic evaluation. The impact of various conditions on the incidence of fracture was evaluated, such as the shape and location of the lead, prior open heart surgery, and the implantation route. The only factor related to the frequency of fractures was the shape of the lead, fractures occurring statistically more frequently if the leads were pulled from their normal J shape into an L or straightened configuration. The frequency of fractures has plateaued at 6 through 9 years with no further occurrence of Class III or IV fractures (protrusion of the fractured segment). Altogether there were nine (1.5%) Class III and Class IV fractures at the 9-year follow-up. Actuarial survival, in Class I or II, was 97%. We concluded, that the frequency of retention wire fractures has plateaued. This information coupled with the knowledge that the Accufix lead extraction can be difficult and dangerous, suggests that the remaining leads are best left in place.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Pacing and clinical electrophysiology 23 (2000), S. 0 
    ISSN: 1540-8159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In addition to its beneficial effect on patient survival, the implanted cardioverter defibriliator (ICD) changes a patient's life physically, socially, and psychologically. For improved patient management, it is important to understand the quality-of-life changes that accompany this mode of treatment. To this end, 119 patients were surveyed retrospectively and interviewed concurrently regarding their emotional, physical, and behavioral responses to ICD shocks and to the device itself. Most (55%) correctly estimated the total number of shocks they had received within a 10% margin. They found the shocks severe, 79% assigning a score between 3 and 5 on a scale of 1–5. Common descriptions of the shock sensation were a blow to the body or a spasm causing the entire body to jump. Most patients tolerated the shocks as life saving, but 23% dreaded shocks and 5% even said they would rather be without the ICD and take their chances. After a shock, 50% of patients called their physician and 42% continued their daily routine. Thirty percent went to a hospital emergency room or called a rescue service. Sixty-five percent had no preshock prodromes. Fifty-four percent were interested in the programmable option of a warning signal prior to a shock, while 31 % preferred no warning. Of the 74% who were advised not to drive after implantation, 29% drove anyway. Five patients were shocked while driving with no resulting accidents. We conclude that most patients find ICD shocks moderately uncomfortable, but they tolerate them because of the lifesaving protection provided by the device.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Pacing and clinical electrophysiology 20 (1997), S. 0 
    ISSN: 1540-8159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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