ISSN:
1432-0428
Keywords:
Insulin-dependent diabetes
;
non-insulin-dependent diabetes
;
glycogen synthase
;
phosphoprotein phosphatases
;
glycogen synthase phosphatase
;
glycosylation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The activation of glycogen synthase after addition of glucose to isolated hepatocytes became impaired in BB rats after the development of insulin-dependent diabetes. This defect was associated with a decreased hepatic synthase phosphatase activity. Both features correspond closely to previous observations on alloxan-diabetic rats. In contrast, in hyperinsulinaemic db/db mice with a similarly increased plasma glucose concentration (non-insulin-dependent diabetes), the synthase phosphatase activity was essentially normal. We conclude that the decreased hepatic synthase phosphatase activity in insulin-dependent diabetes in rodents is due to the lack of insulin, rather than to the increased intrahepatic glucose concentration.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00278757
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