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  • 1
    Electronic Resource
    Electronic Resource
    Kontinuierliche Paracervicalblockade (1971)
    Springer
    Archives of gynecology and obstetrics 211 (1971), S. 375-376 
    Details
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00682986
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  • 2
    Electronic Resource
    Electronic Resource
    How do oocytes disappear? (1975)
    Springer
    Archives of gynecology and obstetrics 218 (1975), S. 233-241 
    Details
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary It has been study using transmision and scanner electron microscopy the mean procedures of dessaparence of the oocytes. On described three methods: 1. The necrosis of the oocytes. 2. The autolysis and fagocitosis by granulosa cells. 3. The migration of those to the superphicie and fall into the peritoneal cavity. Using the scanner electron microscopy in ovaries of fetus and newborn it seems the latest method to bee the most important during the intrauterine life. After the birth, this last phenomenon seems to disappear.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00667384
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  • 3
    Electronic Resource
    Electronic Resource
    Autoradiographie am Plattenepithel der Cervix uteri (1971)
    Springer
    Archives of gynecology and obstetrics 211 (1971), S. 347-349 
    Details
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00682974
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Scanning electron microscopy of the cervix uteri (1974)
    Springer
    Archives of gynecology and obstetrics 216 (1974), S. 91-97 
    Details
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Resumen Se estudian con el microscopio electronico de scanning 5 casos de cuellos uterinos pertenecientes a 2 casos de normalidad, 1 caso de metaplasia indirecta, un carcinoma in situ cuya imagen colposcopica era una erosio vera rodeada de imagenes de leucoplasia mosaico, base y zona de transformación atipica, y un caso de carcinoma invasor. El epitelio poliestratificado normal se caracteriza por una superficie lisa toda ella ocupada por abundantisimos microridges, las celulas son poligonales y de limites claros que resaltan sobre el citoplasma. Las celulas secretoras poseen una superficie llena de microvillis, con un amplio espacio intercelular con largos puentes intercelulares de conexión. En casos de carcinoma in situ e invasor la superficie carecia de microridges y estas estaban ocupadas por innumerables evaginaciones e invaginaciones de forma longitud y tamaño diversos, nunca observados en el epitelio normal. Estas alteraciones de la superficie parecen ser patognomonicas de las celulas neoplasicas.
    Notes: Summary Scanning electron microscopy has been used in the study of five cases of the cervix uteri: two normal cases; one case of indirect metaplasia; one case of carcinoma in situ whose colposcopic examination showed an erosio vera surrounded by leucoplasia, mosaic, base, and an area of atipic transformation zone and one case of invasive carcinoma. The normal ploystratified epithelium is characterized by a smooth surface that abounds in microridges. The cells are polygonal with well defined limits which stand out above the cytoplasm. The secretory cell's surface is covered by microvilli and have an ample intercellular space with long intercellular connecting bridges. In the case of invasive carcinoma and carcinoma in situ, the surface lacks the microridges and is occupied by multiple evaginations and invaginations of diverse length and size never seen in normal polystratified epithelium. These surface alterations seem to be patognomonic of the neoplasic cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00668384
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  • 5
    Electronic Resource
    Electronic Resource
    Distribution of epithelial antigens in the human unterine cervix: A review (1989)
    Springer
    Archives of gynecology and obstetrics 246 (1989), S. 61-84 
    Details
    ISSN: 1432-0711
    Keywords: Immunohistochemistry ; Uterine cervix ; Epithelial markers ; Cervical carcinogenesis ; Monoclonal antibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Epithelial antigen immunostaining in the uterine cervix has been claimed to be helful in the identification and classification of rare lesions, evaluation of basement membrane integrity, study of atypical condylomas, immunodetection of proliferating processes and early diagnosis of malignant transformation. The present review attempts to demonstrate the potential value of immunohistological techniques as a means of identifying normal and abnormal patterns of antigenic expression in cervical epithelium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00934123
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  • 6
    Electronic Resource
    Electronic Resource
    Precocious appearance of markers of squamous differentiation in metaplastic cells of human endocervix (1989)
    Springer
    Archives of gynecology and obstetrics 246 (1989), S. 233-242 
    Details
    ISSN: 1432-0711
    Keywords: Filaggrin ; Involucrin ; Squamous metaplasia ; Uterine cervix
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We used immunoperoxidase methods employing antibodies against involucrin and filaggrin, both markers of squamous terminal differentiation, to study squamous metaplastic transformation in the human endocervix. Expression of involucrin and filaggrin was restricted to squamous metaplastic cells whereas columnar epithelial cells were constantly negative. Immature squamous metaplastic epithelium also showed a positive immunostaining. In mature squamous metaplasia a suprabasal homogeneous staining pattern similar to that found in the exocervical epithelium was detected, although with full-thickness filaggrin immunoreactivity in 45% of cases (P〈0.05). These results support the hypothesis of an epithelial origin of reserve subcolumnar cells, and suggest that precocious squamous differentiation seems to take place in metaplastic cells of the human endocervix.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00934524
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  • 7
    Electronic Resource
    Electronic Resource
    Immunohistochemical localization of filaggrin in benign, premalignant and malignant cervical tissue (1994)
    Springer
    Archives of gynecology and obstetrics 255 (1994), S. 73-79 
    Details
    ISSN: 1432-0711
    Keywords: Filaggrin ; Immunohistochemistry ; Squamous differentiation ; Uterine Cervix
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Epithelial distribution of filaggrin, a histidine-rich protein related to squamous terminal differentiation, was investigated in 87 cervical biopsies using an avidin-biotin-peroxidase technique with a monoclonal anti-human filaggrin antibody (AKH1). Normal squamous cervical epithelium exhibited a positive homogeneous immunoperoxidase stain in the upper parabasal, intermediate and superficial cell layers. Similar findings were obtained in cervical condylomas, although full-thickness staining was observed in 35.7% of the cases (P〈0.001). Filaggrin expression in CIN was inversely related to the severity of the lesion (P〈0.001). An irregular staining pattern was present in most high-grade CIN. Filaggrin expression was closely connected to the degree of tumour differentiation (P〈0.05) in squamous cell carcinomas of the cervix. Abnormal filaggrin stainings identified a premalignant/malignant cervical squamous lesion with a positive predictive value of 92.3%. Non-squamous epithelia showed lack of filaggrin expression. Filaggrin may therefore be considered a marker of squamous differentiation in both the normal and pathological human uterine cervix.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02391801
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  • 8
    Electronic Resource
    Electronic Resource
    Immunohistochemical localization of filaggrin in benign, premalignant and malignant cervical tissue (1994)
    Springer
    Archives of gynecology and obstetrics 255 (1994), S. 73-79 
    Details
    ISSN: 1432-0711
    Keywords: Key words: Filaggrin – Immunohistochemistry – Squamous differentiation – Uterine Cervix
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Epithelial distribution of filaggrin, a histidine-rich protein related to squamous terminal differentiation, was investigated in 87 cervical biopsies using an avidin-biotin-peroxidase technique with a monoclonal anti-human filaggrin antibody (AKH1). Normal squamous cervical epithelium exhibited a positive homogeneous immunoperoxidase stain in the upper parabasal, intermediate and superficial cell layers. Similar findings were obtained in cervical condylomas, although full-thickness staining was observed in 35.7% of the cases (P〈0.001). Filaggrin expression in CIN was inversely related to the severity of the lesion (P〈0.001). An irregular staining pattern was present in most high-grade CIN. Filaggrin expression was closely connected to the degree of tumour differentiation (P〈0.05) in squamous cell carcinomas of the cervix. Abnormal filaggrin stainings identified a premalignant/malignant cervical squamous lesion with a positive predictive value of 92.3%. Non-squamous epithelia showed lack of filaggrin expression. Filaggrin may therefore be considered a marker of squamous differentiation in both the normal and pathological human uterine cervix.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004040050031
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Non-ketotic hyperglycinaemia: prenatal diagnosis and detection of heterozygotes with glycine/serine ratios (1987)
    Springer
    Journal of inherited metabolic disease 10 (1987), S. 198-199 
    Details
    ISSN: 1573-2665
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01800050
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