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  • 1
    ISSN: 0942-0940
    Keywords: Brain neoplasms ; mesial temporal sclerosis ; partial epilepsy ; electroencephalography ; magnetic resonance imaging ; neuropsychology ; positron emission tomography ; epilepsy surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty patients (13 males, 7 females), who presented with refractory partial epilepsy and a CT and/or MR detected intracranial intra-axial structural lesion were admitted to the University of Gent Epilepsy Monitoring Unit. Mean duration of the epilepsy was 17 years (2–47 years). All patients were enrolled in a comprehensive presurgical protocol including neurological examination, videoscalp-EEG monitoring with prolonged interictal and ictal recording, neuropsychological assessment and positron emission tomography (PET). Intracranial EEG monitoring was performed in 5 patients in whom discrepancies between different tests were found during the non-invasive evaluation. Clinical neurological examination was normal in 16 patients; 4 patients had a mild contralateral hemiparesis. Lesions were mainly located in the temporal lobe (55%). Most patients presented with complex partial seizures (90%). Clinical seizure characteristics correlated well with the lesion location in 55% of patients. Interictal EEG showed focal epileptic activity and focal slowing in respectively 85% and 30% of patients. Interictal EEG lateralization was congruent with the side of the lesion in 17 patients (85%). Interictal EEG localization was congruent with the lobe of the lesion in 13 patients (65%). Ictal EEG lateralized correctly in 14 patients (70%) and localized correctly in 10 patients (50%). Neuropsychological assessment lateralized and localized congruently in respectively 8/17 (47%) and 7/17 (41%) of patients. Interictal PET showed focal interictal hypometabolism, congruent with the lesion, in 13/16 (81%) of patients. Intracranial EEG was congruent with the lesion location in 3 patients but non-congruent in 2 patients. All patients underwent surgical procedures: average follow-up was 14 months (6–24 months). Complete surgical removal of the lesion with free margins resulted in a more than 90% reduction of seizures without postoperative neurological deficit in 12/13 patients.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0942-0940
    Keywords: Epilepsy ; electroencephalography (EEG) ; intracranial EEG ; interictal spike ; ictal EEG ; dipole modelling ; epilepsy surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This study includes 11 patients (3 males, 8 females) with mean age of 29 years (range: 15–42 years) who underwent a presurgical evaluation for refractory complex partial seizures (CPS). In all patients, neuroimaging (1.5 T optimum-MR) demonstrated intracranial structural abnormalities (space-occupying: n = 2; atrophic: n = 8; dysplastic: n = 1) and video-EEG monitoring showed CPS. Because of discrepancies in the non-invasive examinations, all underwent additional intracranial EEG monitoring. After tailored resective procedures, all but one patient became seizure free. Mean follow-up was 30 months (range: 12–52 months). Results of intracranial EEG recording were compared with spatiotemporal dipole mapping of interictal and ictal epileptic discharges. Interictal dipole modelling revealed two distinct dipole patterns. Patients with lesions located in the medial temporal lobe uniformly presented a combined dipole that consisted of a radial and a tangential component with a high degree of elevation relative to the axial plane. Patients with extrahippocampal lesions had a less stable dipole with a predominant radial component. Dipole modelling of early ictal discharges revealed a striking correspondence with the interictal findings in individual patients. Elevation of ictal dipoles was always congruent with localisation based on intracranial EEG recordings. Interictal and ictal dipole mapping of medial temporal lobe sources may limit the number of surgical candidates for refractory CPS that need intracranial EEG recording. Whether ictal dipole modelling can be equally useful in extratemporal epilepsy remains to be proven.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0942-0940
    Keywords: Keywords: Vagus nerve stimulation (VNS); refractory epilepsy; EEG; epilepsy surgery; cost-benefit analysis.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary  Introduction. Vagus nerve stimulation is a novel treatment for patients with medically refractory epilepsy, who are not candidates for conventional epilepsy surgery, or who have had such surgery without optimal outcome. To date only studies with relatively short follow-up are available. In these studies efficacy increased with time and reached a maximum after a period of 6 to 12 months. Implantation of a vagus nerve stimulator requires an important financial investment but a cost-benefit analysis has not been published.  Patients and Methods. Our own experience with VNS in Gent comprises 15 patients with mean age of 29 years (range: 17–44 years) and mean duration of epilepsy of 18 years (range: 4–32 years). All patients underwent a comprehensive presurgical evaluation and were found not to be suitable candidates for resective epilepsy surgery. Mean post-implantation follow-up is 24 months (range: 7–43 months). In patients with follow-up of at least one year, efficacy of treatment in terms of seizure control and seizure severity was assessed one year before and after the implantation of a vagus nerve stimulator. Epilepsy-related direct medical costs (ERDMC) before and after the implantation were also compared.  Results. A mean reduction of seizure frequency from 14 seizures/month (range: 2–40/month) to 8 seizures/month (range: 0–30/month) was achieved (Wilcoxon signed rank test n=14; p=0.0016). Five patients showed a marked seizure reduction of ≥50%; 6 became free of complex partial seizures, 3 of whom became entirely seizure free for more than 12 months; 2 patients had a worthwhile reduction of seizure frequency between 30–50%; in 2 patients seizure frequency reduction has remained practically unchanged. Seizure freedom or ≥50% seizure reduction was achieved within the first 4 months after implantation in 6/11 patients. Before the implantation, the mean yearly epilepsy-related direct medical costs per patient were estimated to be 8830US$ (n=13; range: 1879–31129US$; sd=7667); the average number of hospital admission days per year was 21 (range: 4–100; sd=25.7). In the 12 months after implantation, ERDMC had decreased to 4215US$ (range: 615–11794US$; sd=3558) (Wilcoxon signed rank test n=13; p=0.018) and the average number of admission days to 8 (range: 0–35) (Wilcoxon signed rank test n=13; p=0.023).  Conclusion. VNS is an effective treatment of refractory epilepsy and remains effective during long-term follow-up. Cost-benefit analysis suggests that the cost of VNS is saved within two years following implantation.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 0003-2697
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Freshwater biology 6 (1976), S. 0 
    ISSN: 1365-2427
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: A comprehensive temperature survey of the River North Tyne and its major tributaries is described. The maximum summer temperature of the main river increased downstream, and then remained more or less constant in the middle and lower reaches, whereas the minimum continued to rise throughout the length of the river. This general pattern was unaltered by flow rate, except in regions of almost stationary water. Mean water temperatures were low in winter, rose to a peak in July, and then fell during the remainder of the year. Throughout the year, three significantly different mean daily temperature ranges were demonstrated. The rate of change of temperature also varied seasonally, being greatest during July. A study of the major tributaries revealed certain differences, and these are discussed, particularly in relation to the importance of width and shading on water temperature. In conclusion, suggestions have been made concerning the possible influence of Kielder Water on downstream river temperatures.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Freshwater biology 14 (1984), S. 0 
    ISSN: 1365-2427
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: SUMMARY. 1. Trichopteran populations below a dam on the River Tuntang (Central Java) and on intake screens above the dam consisted almost exclusively of Amphipsyche meridiana. Larvae on dam screens were in tightly packed aggregations, with greater densities in deeper water, and were predominantly fourth or fifth instars during the period of observation. Below the dam, 40% of larvae were in the first three instars. Larvae at the dam screens were heavier and yielded larger emerging adults which contained more eggs per female.2. Mean net mesh sizes of fifth instar larvae varied greatly from 34×26 μm to 125×106 μm with larger meshes having progressively thicker strands. It is suggested that larger mesh size may be positively correlated with faster flow rates. The dinoflagellate Peridinium, commonly found in the guts of larvae below the dam, was virtually absent in dam screen larvae, possibly due to mesh size differences.3. The behaviour of larvae in aggregations was observed in a laboratory flow channel. After experimental destruction of feeding nets, larvae immediately ingested silk prior to the construction of a new net. Nets were spun in a‘figure 8’fashion, and took between 11 and 30 min to complete. Stridulation between larvae occurred frequently and may be related to the defence of silk reserves within territories.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Magnetic Resonance (1969) 54 (1983), S. 54-66 
    ISSN: 0022-2364
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Water and environment journal 5 (1991), S. 0 
    ISSN: 1747-6593
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: The Nature Conservancy Council has welcomed the implementation of the EC Directive on the assessment of the effects of certain projects on the environment. This paper discusses its implications for nature conservation in fresh waters, particularly with reference to the land-drainage and flood-defence work carried out by the National Rivers Authority and its predecessors, to which the regulations SI 1217 apply. Environmental statements have been deemed necessary for only a small proportion of capital schemes initiated by the water industry since the Regulations came into force in 1988. The author has evaluated the nature-conservation content of 15 of these statements against a combined set of objective and subjective criteria. The statements examined showed a high degree of variability in length, scope, style and presentation. In general, survey and data acquisition were poorly covered. The weakest area was considered to be the evaluation and prediction of potential impacts, and this is discussed in relation to the uncertainty and complexity inherent in biological systems. The need for monitoring the accuracy of predictions after the completion of a scheme received little attention, despite its fundamental importance in improving future project design, and in extending scientific understanding.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-1459
    Keywords: Carbon monoxide poisoning ; Hyperbaric oxygen treatment ; Positron emission tomography ; Delayed neurological deterioration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Seven patients with an acute and severe carbon monoxide intoxication were treated with hyperbaric oxygen and underwent a positron emission tomographic examination 2–5 days after the acute event. Although the final clinical outcome was good in all patients, ischaemic changes were observed. Three patients with temporary sequelae after hyperbaric oxygen treatment showed the most severe changes, mainly in striatum and thalamus. Although positron emission tomographic examination cannot predict the final outcome, it can show the regions at risk for development of late complications following carbon monoxide poisoning.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Samples of sediments from Australian seagrass (Zostera capricorni Aschers.) beds were taken in June to August 1983 (for15N experiments) and November 1982 to January 1983 (14N experiments). The ammonium pool turned-over every 0.4 to 0.8 d, as determined with a15N isotope-dilution technique. The ammonium pool in subtidal bare areas turned-over two to three times more slowly than in adjacent seagrass beds. Gross rates ofin situ ammonium regeneration equalled those of utilization, and ranged from 0.04 to 0.35 μmol cm-3 d-1, or from 50 to 490 mg N m-2 d-1 over the upper 10 cm of the sediment. The potential rate of glycine utilization, measured with a large excess of glycine added to anaerobic incubations, ranged from 0.21 to 0.39μmol cm-3 d-1, butin situ rates were probably much lower. Between 35 and 65% of added15N-glycine was deaminated over 12 h, and the remainder was most likely assimilated by microbes. Evidence for the seagrasses taking up glycine was equivocal, owing to the rapid deamination of the amino acid and the likelihood that they assimilated the labelled ammonium produced from the glycine.
    Type of Medium: Electronic Resource
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