ISSN:
1432-0991
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract B6C3F1 mice from a hybrid production colony frequently were serologically positive by enzyme-linked immunosorbent assay (ELISA) and consistently negative by culture forMycoplasma pulmonis. Subsequently, 162 mice were obtained and intensively studied using an expanded group of cultural procedures, ELISA, and histopathology. Lesions attributable to mycoplasma infection were not found, butMycoplasma arthritidis was isolated from 20 mice. TheM. pulmonis ELISA was positive (IgM, IgG, or both) in 113 mice. Selected sera were tested simultaneously in both theM. pulmonis ELISA and in an ELISA usingM. arthritidis antigen, and were found to be positive in both the IgM and IgG classes in both ELISAs. Thus, cross-reacting antibody was produced in mice naturally infected withM. arthritidis, confirming previous observations based on experimental infections. To our knowledge, this is the first report of naturalM. arthritidis infection in laboratory mice.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01579547
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