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  • 1
    Electronic Resource
    Electronic Resource
    Hypothalamic obesity (1981)
    Springer
    Diabetologia 20 (1981), S. 366-377 
    Details
    ISSN: 1432-0428
    Keywords: Sympathectomy ; unilateral hypothalamic lesions ; insulin ; glucagon ; body fat ; food intake ; atropine ; epinephrine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Several lines of evidence support the hypothesis that derangements in the function of the autonomic nervous system play an important role in the development of hypothalamic obesity. Vagotomy below the diaphragm reverses the syndrome. In diabetic rats cured of their diabetes with transplants of fetal pancreatic tissue beneath the renal capsule, ventromedial hypothalamic (VMH) lesions do not produce the characteristic rise in food intake nor do they significantly increase serum insulin. These observations indicate that the hyperinsulinaemia following VMH lesions is the result of neural connections rather than from a circulating humoral factor released following VMH injury. The smaller salivary glands, reduced level of glucagon and impaired mobilization of fatty acids during stress in VMH lesioned rats point to reduced activity of the sympathetic nervous system. The impaired mobilization of fat from retroperitoneal depots in VMH lesioned rats during fasting is similar to the effect of sympathetic denervation of the retroperitoneal fat pad. Similarly, unilateral sympathectomy caused an increased weight gain in rats almost as much as unilateral VMH lesions but significantly less than in bilaterally lesioned rats. These studies with fasting and feeding implicate the VMH in the control of the sympathetic nervous system. When atropine and epinephrine were given to VMH lesioned rats, there was a significant depression in basal and glucose-stimulated levels of insulin. Finally when VMH lesions were placed after lateral hypothalamic lesions, the effect of the VMH lesions did not seem to be reduced, suggesting that the two effects are independent. A model dealing with the effects of VMH lesions is presented in an attempt to integrate these findings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00254505
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of Nerve Growth Factor antiserum on peripheral unmyelinated nerve fibers (1972)
    Springer
    Acta neuropathologica 20 (1972), S. 288-298 
    Details
    ISSN: 1432-0533
    Keywords: Nerve Growth Factor ; Peripheral Nerve Fibres ; Schwann Cells ; Electron Microscopy ; Phase Contrast
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Nerve Growth Factor (NGF) antiserum causes neuronal loss in the sympathetic ganglia of newborn rats. Pre and post ganglionic sympathetic fibers from eleven such animals and eight controls were studied by phase contrast and electron microscopy. Quantitative techniques were applied to the study of different parameters of the axons and Schwann cells. Treated animals showed only 24% of the axonal population of controls and 34% of Schwann cells. This fiber loss was non-selective, affecting all fiber sizes. Schwann cells from treated animals enclosed fewer axons than normal and some contained none. Contrary to what is seen following transection of an unmyelinated nerve, regenerative axonal sprouting was not observed during the 6 week period studied. Schwann cell processes were elongated and unfolded, frequently engulfing bundles of collagen. NGF antiserum experiments provide a tool for the study of axonal and Schwann cell behaviour after neuronal loss avoiding the disadvantages of the traumatic disruption of neural architecture that results from experimental surgical lesions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691747
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  • 3
    Electronic Resource
    Electronic Resource
    Paper Hygrometers (1933)
    [s.l.] : Nature Publishing Group
    Nature 132 (1933), S. 857-857 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IN connexion with Dr. J. Grant's letter1, on paper hygrometers, some experiments made some months ago on an experimental paper-operated indicating hygrometer may be of interest. The instrument, in aspect similar to the ‘Edney’ paper-metal hygrometer, was made by causing two ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/132857b0
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  • 4
    Electronic Resource
    Electronic Resource
    Binocular Illusion (1938)
    [s.l.] : Nature Publishing Group
    Nature 142 (1938), S. 959-959 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IN the correspondence on this subject, there does not appear to be mention of the facility for viewing stereoscopic photographs possessed by those who can comply with Mr. J. D. Morton's manner of viewing a lattice1. In this case, as distinct from the binocular sequence ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/142959a0
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  • 5
    Electronic Resource
    Electronic Resource
    Deoxyribonucleoside 5'-triphosphate pool fluctuations during the mamalian cell cycle
    Amsterdam : Elsevier
    BBA Section Nucleic Acids And Protein Synthesis 269 (1972), S. 184-191 
    Details
    ISSN: 0005-2787
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0005-2787(72)90425-X
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  • 6
    Electronic Resource
    Electronic Resource
    Abnormal myelination in transplanted Trembler mouse Schwann cells (1977)
    [s.l.] : Nature Publishing Group
    Nature 265 (1977), S. 73-75 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] To define further the abnormality in Tr neuropathy, sciatic nerves and spinal roots from six affected mice and five control C57BL/6J mice aged 14 d to 7 month were examined by phase and electron microscopy6,15. In normal nerves, most axons greater than 1mm in diameter were surrounded by Schwann ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/265073a0
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  • 7
    Electronic Resource
    Electronic Resource
    Weight Homeostasis (1991)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Medicine 42 (1991), S. 205-216 
    Details
    ISSN: 0066-4219
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.me.42.020191.001225
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  • 8
    Electronic Resource
    Electronic Resource
    Clinical evaluation of an advanced category antihaemophilic factor prepared using a plasma/albumin-free method: pharmacokinetics, efficacy, and safety in previously treated patients with haemophilia A (2004)
    Oxford, UK : Blackwell Science Ltd
    Haemophilia 10 (2004), S. 0 
    Details
    ISSN: 1365-2516
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary.  The efficacy and safety of an advanced category recombinant antihaemophilic factor produced by a plasma- and albumin-free method (rAHF-PFM) was studied in 111 previously treated subjects with haemophilia A. The study comprised a randomized, double-blinded, crossover pharmacokinetic comparison of rAHF-PFM and RECOMBINATE rAHF (R-FVIII); prophylaxis (three to four times per week with 25–40 IU kg−1 rAHF-PFM) for at least 75 exposure days; and treatment of episodic haemorrhagic events. Median age was 18 years, 96% of subjects had baseline factor VIII 〈1%, and 108 received study drug. Bioequivalence, based on area under the plasma concentration vs. time curve and adjusted in vivo recovery, was demonstrated for rAHF-PFM and R-FVIII. Mean (±SD) half-life for rAHF-PFM was 12.0 ± 4.3 h. Among 510 bleeding events, 473 (93%) were managed with one or two infusions of rAHF-PFM and 439 (86%) had efficacy ratings of excellent or good. Subjects who were less adherent to the prophylactic regimen had a higher bleeding rate (9.9 episodes subject−1 year−1) than subjects who were more adherent (4.4 episodes subject−1 year−1; P 〈 0.03). One subject developed a low titre, non-persistent inhibitor (2.0 BU) after 26 exposure days. These data demonstrate that rAHF-PFM is bioequivalent to R-FVIII, and suggest that rAHF-PFM is efficacious and safe, without increased immunogenicity, for the treatment of haemophilia A.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2516.2004.00932.x
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  • 9
    Electronic Resource
    Electronic Resource
    Low factor VIII recovery in haemophilia A patients without inhibitor titre is not due to the presence of anti-factor VIII antibodies undetectable by the Bethesda assay (2001)
    Oxford UK : Blackwell Science Ltd
    Haemophilia 7 (2001), S. 0 
    Details
    ISSN: 1365-2516
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Measurements of factor VIII (FVIII) recovery in previously untreated patients with haemophilia A were done as part of the clinical trial of safety and efficacy of the recombinant FVIII, Recombinate™. In 22 of 72 assessable patients, positive inhibitor titres ≥ 0.6 Bethesda units mL−1 were detected by the Bethesda assay in one or more plasma samples, and the remaining 50 patients were negative at all timepoints. Of the latter group, 16 individuals without inhibitors unexpectedly had both normal (111) and low (52) recoveries during the study. We investigated the possibility that other antibodies not detectable in the Bethesda assay were responsible for the low recovery, by using a highly sensitive immunopreciptation (IP) assay for detection of all antiFVIII antibodies. Eight of the 16 patients with low and normal recoveries did indeed have antibodies detected by the IP assay, and the remaining eight were negative. Four antibody-positive individuals had insignificantly low titres, and the other four had modest to high titres. In the latter group, antibodies were found with similar frequencies and titre in plasmas from patients with low or normal recovery. Low recovery in haemophilia A patients without inhibitor titres must therefore be attributed to factors other than antiFVIII.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2516.2001.00463.x
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  • 10
    Electronic Resource
    Electronic Resource
    New end station for the study of gases, liquids, and solid films at the MAX laboratory (1996)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 67 (1996), S. 2149-2156 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A new end station equipped with a very high-resolution SES-200 electron energy analyzer has been constructed for the study of gases and soft molecular materials. The analyzer is rotatable around the direction of the photon beam, allowing angular-dependent studies. The system has been built in a way allowing the investigation of free molecules and atoms, metal vapors, liquid interfaces as well as solid films. The first electron spectroscopy results for gases, liquids, and polymer films are presented. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1147029
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