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  • 1
    Electronic Resource
    Electronic Resource
    Receptors for thymosin fraction V on rat thymic lymphocytes (1982)
    Springer
    Cellular and molecular life sciences 38 (1982), S. 1317-1318 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Binding by rat thymus lymphocytes of thymosin V, labeled with colloidal gold, was studied. Under the experimental conditions employed at least 2.8% cells exhibited thymosin binding sites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01954924
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  • 2
    Electronic Resource
    Electronic Resource
    Receptors for thymosin fraction V on rat thymic lymphocytes (1982)
    Springer
    Cellular and molecular life sciences 38 (1982), S. 618-619 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Binding by rat thymus lymphocytes of thymosin V, labeled with colloidal gold, was studied. Under the experimental conditions employed at least 2.8% cells exhibited thymosin binding sites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02327082
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  • 3
    Electronic Resource
    Electronic Resource
    Proteins contained in Thymus Factor X bind to the surface of rat thymocytes (1979)
    Springer
    Histochemistry and cell biology 63 (1979), S. 341-346 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary By means of an immunocytochemical method, using an antiserum directed against Thymus Factor X (TFX) the presence of TFX-cross-reactive antigen on the surface of rat thymocytes was demonstrated. In the electron microscope, the product of the immunocytochemical reaction was localized as a fine granular and electron opaque material on the surface of some medium-size and small thymocytes. It was shown that the intensity and distribution pattern of the reaction product on the surface of the thymocytes varied markedly. Preincubation of thymocytes with TFX resulted in more intense labelling. The presence of TFX and cross-reactive native thymic antigens on the surface of rat thymocytes as revealed by anti-TFX serum, allows us to suppose that these thymic proteins are bound to surface of the cells by specific surface receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00490062
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  • 4
    Electronic Resource
    Electronic Resource
    Subtypes of thymic epithelial cells defined by neuroendocrine markers (2000)
    Springer
    Histochemistry and cell biology 114 (2000), S. 239-244 
    Details
    ISSN: 1432-119X
    Keywords: Thymic epithelial cells Neuroendocrine markers expression Immunocytochemistry Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. The study attempted to define characteristics of thymic epithelial cells within rat thymus based on the expression of neuroendocrine markers. Using an immunohistochemical approach, the following markers were localised: protein gene product 9.5 (PGP 9.5), neuron-specific enolase (NSE) and chromogranin A (ChA). It was shown that cells displaying immunostaining typical for individual markers reside in distinct regions of the thymus and represent subtypes within various populations of thymic epithelial cells. An immunoreactivity for PGP 9.5 was found exclusively in a subtype of cortical epithelial cells, located mostly within the inner zone of the cortex. On the other hand, NSE represented a marker of most epithelial cells located in the medulla. Few such cells which were negative for NSE proved positive for ChA. Among the cells with a strong reaction for NSE some cells also manifested a positive reaction for ChA. While the pattern of neuroendocrine marker distribution may reflect functional properties of thymic epithelial cells which might be different within distinct areas of the thymus, the differential expression of individual markers seems to reflect biological activity of the cells and/or distinct stages of their differentiation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004180000187
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  • 5
    Electronic Resource
    Electronic Resource
    Thymic nurse cells: division of thymocytes within complexes (1989)
    Springer
    Cell & tissue research 258 (1989), S. 637-643 
    Details
    ISSN: 1432-0878
    Keywords: Thymic nurse cells ; Thymic cell complexes ; Thymocytes ; Autoradiography ; Mouse (BDF1)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Thymic nurse cell complexes (TNC-c), isolated from mouse thymuses at 1 and 2 h after i.v. injection of 6-(3H)thymidine, were analyzed in autoradiographs of semithin serial sections with regard to their size and the distribution of labeled thymocytes in individual types of complexes. The total number of thymocytes per complex reflects the type of complex. In a parallel study, localization of labeled thymocytes within individual zones of thymic cortex was examined. Thymocyte division within complexes may yield sequential complex generations differing in number per complex. However, thymocytes within complexes differ from each other in division kinetics. Half of the thymocytes that had been labeled 1 h after injection divided within 2 h. The rapidly dividing fraction of thymocytes were distributed within small complexes containing 2–8 cells and corresponded to the distribution of labeled cells in the outer thymic cortex. The proportion of labeled cells within large complexes resembled the distribution of labeled cells in the deep cortex. The data support the view that microenvironmental factors within TNC-c are responsible for both inducing thymocytes to enter the cell cycle and the negative selection (cell death) of some thymocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00218877
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  • 6
    Electronic Resource
    Electronic Resource
    The significance of the subcompartments of the marginal zone for directing lymphocyte traffic within the splenic pulp of the rat (1982)
    Springer
    Cell & tissue research 226 (1982), S. 155-165 
    Details
    ISSN: 1432-0878
    Keywords: Spleen (rat) ; Lymphocytes ; Autoradiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary These studies were designed to gain more detailed information on the sites of lymphocyte migration into the marginal zone, on lymphocyte segregation within this area and on subsequent migration of the cells in individual compartments of the rat spleen. A lymphocyte population enriched in T-lymphocytes was obtained from rat lymph nodes and was labeled with 5-(3H)uridine in vitro. Observations on localization of labeled lymphocytes at short time intervals following their intravenous transfusion into syngeneic recipients, indicate that the sites of emigration from the blood are the internal and external layers of the marginal zone. From here, the cells migrate towards the periarteriolar lymphoid sheath and the red pulp.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00217090
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  • 7
    Electronic Resource
    Electronic Resource
    Macrophages and interdigitating cells; their relationship to migrating lymphocytes in the white pulp of rat spleen (1983)
    Springer
    Cell & tissue research 233 (1983), S. 671-688 
    Details
    ISSN: 1432-0878
    Keywords: Lymphocytes ; Spleen ; Migration ; Autoradiography ; Interdigitating cells ; Marginal zone macrophages
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The pathway of lymphocyte migration through the white pulp of rat spleen and the relationship of migrating cells to the accessory cells (marginal zone macrophages and interdigitating cells, IDCs) of the white pulp compartments were analysed. Donor lymphocytes were obtained from lymph nodes, enriched for T lymphocytes and labeled in vitro with 5-(3H)uridine. They were injected intravenously into syngeneic recipients from which samples of spleen were taken at short intervals from 3 to 300 min after injection. Autoradiographs of semithin and ultrathin sections showed that, in the internal layer of the marginal zone (MZ), lymphocytes tended to accumulate within some regions in close proximity to marginal-zone macrophages before migrating into the periarteriolar lymphoid sheath (PALS). The lymphocytes enter PALS between protrusions of the accessory cells located in the peripheral area of the sheath. During migration towards the central area of PALS, a close contact between both cell types was noted. In the central area of PALS, preferential accumulation of lymphocytes around IDCs was observed. Labeled lymphocyte distribution within PALS and the rate of cell migration through the white pulp seem to depend on lymphocyte-IDC contact. A common feature of accessory cells which may affect the migration of lymphocytes in both MZ and PALS is the presence of Birbeck granules.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00212234
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  • 8
    Electronic Resource
    Electronic Resource
    Pathways of lymphocyte migration within the periarterial lymphoid sheath of rat spleen (1984)
    Springer
    Cell & tissue research 236 (1984), S. 661-667 
    Details
    ISSN: 1432-0878
    Keywords: Lymphocytes ; Spleen ; Autoradiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Male Wistar rats were injected intravenously with 5-(3H)uridine-labeled lymphocytes isolated from lymph nodes of syngeneic donors and enriched in T cells. After short periods of time (3 to 120 min after injection), labeled lymphocytes were localized in spleen compartments using autoradiography to identify routes of lymphocyte movement from blood into splenic parenchyma and to follow migration pathways of recirculating lymphocytes within the periarterial lymphoid sheath (PALS). Topographical analysis of labeled lymphocytes was performed in specific planes of PALS characterized by the diameter of the arterial vessel and termed PALS large, PALS medium, and PALS small (PALS L, PALS M, PALS S, respectively). Attention was also paid to accumulations of labeled lymphocytes close to the arterial vessel wall. Initially, labeled lymphocytes were localized in PALS S and PALS M near the terminal branching of arterial vessels and in the marginal zone (MZ). We conclude that lymphocytes emigrate from blood into splenic parenchyma within two white pulp compartments: in MZ, and directly within PALS through the wall of capillary vessels. The sequential accumulation of labeled cells near arterial vessels of increasing diameter suggests that the recirculating pool of lymphocytes migrates into the central part of PALS L by two routes: from MZ, and along arterial vessels from PALS S and PALS M.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00217236
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  • 9
    Electronic Resource
    Electronic Resource
    Distribution of different cell types within the rat thymus in the neonatal period of life (1985)
    Springer
    Cell & tissue research 240 (1985), S. 473-478 
    Details
    ISSN: 1432-0878
    Keywords: Thymus ; Non-lymphoid cells ; Cell contacts ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary This study attempted to define reciprocal positions of cell types within the thymus. Random or non-random contacts between specific cell types were analyzed by means of graph theory. For analysis, thymus blocks were sectioned serially and, then, thymus cells were categorized into types, based on morphological criteria. The distribution of individual cell types within the cortex, cortico-medullary zone and medulla was presented in form of a map. In the analysis, three types of epithelial cell, characteristic of each thymus zone, macrophages, Langerhans-like cells and lymphocytes were found in non-random relations to one another. Moreover, characteristic groups of cells associated with one another were also demonstrated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00222362
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  • 10
    Electronic Resource
    Electronic Resource
    Multicellular complexes of thymocytes and different types of thymic stromal cells in the mouse (1986)
    Springer
    Cell & tissue research 244 (1986), S. 673-679 
    Details
    ISSN: 1432-0878
    Keywords: Thymic cell complexes ; Nonlymphoid thymic cells ; Thymus ; Mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The isolation of multicellular complexes of thymocytes and different types of thymic stromal cells from the mouse thymus is described. Isolated complexes were examined by light microscopy. Stromal cells, binding thymocytes at their surface, were identified using electron microscopy, and three types of epithelial cells, macrophages and interdigitating-like cells (IDC-like cells) were distinguished from their morphological characteristics. The epithelial cell types correspond morphologically to epithelial cells present in situ in various thymic regions. The type of thymocyte-contact with epithelial cells, macrophages and IDC-like cells indicated that the formation of multicellular complexes is common.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00212548
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