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  • 1
    Electronic Resource
    Electronic Resource
    The sensory guidance of movement: a comparison of the cerebellum and basal ganglia (1996)
    Springer
    Experimental brain research 112 (1996), S. 462-474 
    Details
    ISSN: 1432-1106
    Keywords: Positron emission tomography ; Basal ganglia ; Cerebellum ; Prefrontal cortex ; Parietal cortex
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We used positron emission tomography (PET) to compare the contribution of the cerebellum and basal ganglia to the sensory guidance of movement. In one condition the subjects used a computer mouse to draw a series of lines on a computer screen (DRAW). In the second condition the same lines were presented to the subjects, and they had to track the lines with a mouse pointer on the screen (COPY). In a third condition the subjects were again presented with the same lines, and they simply followed movements of the pointer with their eyes (EYES). In the fourth condition, the subjects fixated a central point, ignoring the sequence of presented lines (FIX). The pons and cerebellum were activated more during visually guided tracking than in freely generated drawing (COPY vs DRAW). The basal ganglia were activated equally in both DRAW and COPY. The prefrontal and inferior temporal cortex were activated more when subjects drew lines freely (DRAW) than when they copied them (COPY). We conclude that the cerebellum is specialized for using sensory information to correct movements, but that the basal ganglia are involved both in movements that are self-generated and in movements that are guided by external cues.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00227952
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Evidence for striatal dopamine release during a video game (1998)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 393 (1998), S. 266-268 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Dopaminergic neurotransmission may be involved in learning, reinforcement of behaviour, attention, and sensorimotor integration,. Binding of the radioligand 11C-labelled raclopride to dopamine D2 receptors is sensitive to levels of endogenous dopamine, which can be ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/30498
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Positron emission tomography studies of neurotransmitter systems (1990)
    Springer
    Journal of neurology 237 (1990), S. 451-456 
    Details
    ISSN: 1432-1459
    Keywords: Positron emission tomography ; Dopamine ; Parkinson's disease ; Opiates ; Epilepsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This article focuses on the use of positron emission tomography (PET) with radiolabelled pharmaceuticals as a quantitative tool for the measurement of neurotransmitter systems. We describe the methods of image acquisition and data analysis used to study the dopaminergic system and review the contribution of such studies to our understanding of movement disorders. PET studies of the opiate system are briefly reviewed and ongoing studies of benzodiazepine receptors, monoamine oxidase inhibitors and the serotoninergic system are described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00314760
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Morphological and functional imaging studies on the diagnosis and progression of Parkinson’s disease (2000)
    Springer
    Journal of neurology 247 (2000), S. II11 
    Details
    ISSN: 1432-1459
    Keywords: Key Words Diagnosis ; MRI ; MRS ; Parkinson’s disease ; SPECT ; PET
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This paper reviews the relative abilities of magnetic resonance imaging (MRI), positron emission tomography (PET), single photon emission tomography (SPECT), and proton magnetic resonance spectroscopy (MRS) to detect Parkinson’s disease and monitor its progression. Currently, the main role of MRI lies in its ability to discriminate atypical syndromes from Parkinson’s disease; however, new volumetric approaches may soon allow progression of nigral degeneration to be followed. Proton MRS can also detect reduced levels of putamen N-acetyl aspartate (NAA) in many patients with atypical parkinsonian syndromes. PET and SPECT are both sensitive means of detecting the presence of impaired dopamine terminal function in the striatum and following its progression. PET currently has the greater spatial resolution and provides the added advantages that it also allows extra-striatal dopaminergic function to be monitored.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00007755
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    Paper (German National Licenses)
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