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  • 1
    Electronic Resource
    Electronic Resource
    The Specific Polysaccharide of Type XVIIIA Pneumococcus* (1964)
    s.l. : American Chemical Society
    Biochemistry 3 (1964), S. 1548-1550 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00898a027
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Are There “Autistic-like” Features in Congenitally Blind Children? (1997)
    Oxford, UK : Blackwell Publishing Ltd
    The @journal of child psychology and psychiatry 38 (1997), S. 0 
    Details
    ISSN: 1469-7610
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Twenty-four congenitally blind children between 3 and 9 years of age were studied for the prevalence of “autistic-like” features, as assessed by teacher reports and by systematic observations of the children's behaviour. A comparison between the 15 blind children who had IQs over 70 and 10 sighted children group-matched for age and verbal ability revealed that a number of autistic-like features were more common in the blind. When the nine blind children who had IQs less than 70 were compared with nine group-matched autistic children, the picture that emerged was of substantial overlap in clinical presentation, despite subtle differences on clinical impression. Similar results were obtained when blind subgroups were reconstituted according to the children's non autistic or autistic-like clinical presentation, rather than IQ. These findings are discussed in relation to competing theories concerning the development of autism and “theory of mind”.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1469-7610.1997.tb01696.x
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  • 3
    Electronic Resource
    Electronic Resource
    NYSTATIN (1960)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 89 (1960), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1960.tb20148.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    22R-Hydroxycholesterol protects neuronal cells from β-amyloid-induced cytotoxicity by binding to β-amyloid peptide (2002)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 83 (2002), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 22R-hydroxycholesterol, a steroid intermediate in the pathway of pregnenolone formation from cholesterol, was found at lower levels in Alzheimer's disease (AD) hippocampus and frontal cortex tissue specimens compared to age-matched controls. β-Amyloid (Aβ) peptide has been shown to be neurotoxic and its presence in brain has been linked to AD pathology. 22R-hydroxycholesterol was found to protect, in a dose-dependent manner, against Aβ-induced rat sympathetic nerve pheochromocytoma (PC12) and differentiated human Ntera2/D1 teratocarcinoma (NT2N) neuron cell death. Other steroids tested were either inactive or acted on rodent neurons only. The effect of 22R-hydroxycholesterol was found to be stereospecific because its enantiomer 22S-hydroxycholesterol failed to protect the neurons from Aβ-induced cell death. Moreover, the effect of 22R-hydroxycholesterol was specific for Aβ-induced cell death because it did not protect against glutamate-induced neurotoxicity. The neuroprotective effect of 22R-hydroxycholesterol was seen when using Aβ1−42 but not the Aβ25−35 peptide. To investigate the mechanism of action of 22R-hydroxycholesterol we examined the direct binding of this steroid to Aβ using a novel cholesterol-protein binding blot assay. Using this method the direct specific binding, under native conditions, of 22R-hydroxycholesterol to Aβ1−42 and Aβ17−40, but not Aβ25−35, was observed. These data suggest that 22R-hydroxycholesterol binds to Aβ and the formed 22R-hydroxycholesterol/Aβ complex is not toxic to rodent and human neurons. We propose that 22R-hydroxycholesterol offers a new means of neuroprotection against Aβ toxicity by inactivating the peptide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.2002.01202.x
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  • 5
    Electronic Resource
    Electronic Resource
    Pathways of Neurosteroid Biosynthesis in Cell Lines from Human Brain (2000)
    Oxford UK : Blackwell Science Ltd
    Journal of neurochemistry 74 (2000), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Neurosteroids in rodents can originate from peripheral tissues or be locally synthesized in specific brain areas. There is, as yet, no information about the synthesis and regulation of neurosteroids in human brain. We examined the ability of human brain cells to synthesize steroids from a radiolabeled precursor and the mRNA and protein expression of key components of peripheral steroidogenic machinery. Oligodendrocytes are the source of pregnenolone in human brain. Human astrocytes do not synthesize radiolabeled pregnenolone, nor do human neurons. There is potential for all three cell types to metabolize pregnenolone to other neurosteroids, including dehydroepiandrosterone. mRNA and protein for cytochrome P450 17α-hydroxylase were found in all cell types, although no activity could be demonstrated. We examined the ability of the cells to make dehydroepiandrosterone via an alternative pathway induced by treatment with Fe2+. Oligodendrocytes and astrocytes make dehydroepiandrosterone via this pathway, but neurons do not. In searching for a natural regulator of dehydroepiandrosterone formation, we observed that treating oligodendrocytes with β-amyloid, which increases reactive oxygen species, also increased dehydroepiandrosterone formation. These effects of β-amyloid were blocked by vitamin E. These results indicate that human brain makes steroids in a cell-specific manner and suggest that dehydroepiandrosterone synthesis can be regulated by intracellular free radicals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.2000.740847.x
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    The Production of 3-Benzylidene-6-isobutylidene-2,5-dioxopiperazine, 3,6-Dibenzylidene-2,5-dioxopiperazine, 3-Benzyl-6-benzylidene-2,5-dioxopiperazine, and 3,6-Dibenzyl-2,5-dioxopiperazine by a Variant of Streptomyces noursei1 (1965)
    s.l. : American Chemical Society
    The @journal of organic chemistry 30 (1965), S. 277-280 
    Details
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jo01012a066
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Working alongside the general practitioner: a child psychiatric clinic in the general practice setting (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Child 16 (1990), S. 0 
    Details
    ISSN: 1365-2214
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Summary A monthly child psychiatric clinic was established in a primary health care centre in order to offer a more accessible service to patients, and to improve liaison with primary health care professionals. Compared with the base child guidance unit, at the health centre there was a better first attendance rate, a much higher proportion of referrals from health professionals especially general practitioners, and an increased proportion of younger children referred. If further follow-up was necessary at the child guidance unit the attendance rate was very good. The service provided, although not reducing the need for a main multidisciplinary base, offered an acceptable and accessible opportunity for children with psychological problems to be assessed and treated, and for the referring professionals to have easy communication with the child psychiatrist.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2214.1990.tb00650.x
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  • 8
    Electronic Resource
    Electronic Resource
    Advancing social justice as a part of educational leadership development: The potential of imaging technologies (2002)
    Bradford : Emerald
    On the horizon 10 (2002), S. 12-15 
    Details
    ISSN: 1085-4959
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Education , Economics
    Notes: We discuss beneficial uses of imaging technologies in higher education that advance social justice. Misuse and ineffectiveness of shared decision making, specifically as related to power relationships and the redistribution of decision-making authority, are addressed through the development of technologically delivered experiential simulations (ES). We outline ways in which ES can change higher education preparation programs to meet and adapt to the challenges of the future. ES entails using computer technology to modify a person's appearance and thereby evoking an atypical response from an audience. The key to our proposal, however, is having the person with the modified persona learn lessons pertinent to democratic cultures and social justice from their experience of immersion in that response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/10748120210446424
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  • 9
    Electronic Resource
    Electronic Resource
    The production of leucylphenylalanine anhydride by a variant ofStreptomyces noursei (1966)
    Springer
    Cellular and molecular life sciences 22 (1966), S. 721-722 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Résumé A partir de cultures deStreptomyces noursei, variante No. 5286, on a isolé la 3-benzyl-6-isobutyl-2, 5-dioxopipérazine, en plus des quatre dioxopipérazines disubstituées dont la présence a été signalée précédemment; on n'a pas obtenu de preuve de l'existence d'un dérivé 3-benzylidène-6-isobutyl-ou 3-benzyl-6-isobutylidènecorrespondant à la 3-benzyl-6-benzylidène-2,5-dioxopipérazine déjà connue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01901338
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  • 10
    Electronic Resource
    Electronic Resource
    Autism and Congenital Blindness (1999)
    Springer
    Journal of autism and developmental disorders 29 (1999), S. 45-56 
    Details
    ISSN: 1573-3432
    Keywords: Autism ; congenital blindness
    Source: Springer Online Journal Archives 1860-2000
    Topics: Psychology
    Notes: Abstract The nature of autism in congenitally blind children has long been a source of interest and perplexity. A group of nine congenitally blind children with an autism-like syndrome were closely matched on chronological age and verbal mental age with nine sighted autistic children, and were compared on the Childhood Autism Rating Scale (Schopler, Reichler, & Renner, 1986) and the Behavior Checklist for Disordered Preschoolers, together with the Play Items for Disordered Preschoolers (Sherman, Shapiro, & Glassman, 1983). A checklist of clinical features characteristic of autism (derived from DSM-III-R) was also completed through an interview with teachers. There was substantial similarity between the groups, but also suggestive evidence of possible group differences, specifically in the domain of social-emotional responsiveness. Research on the psychological development of congenitally blind children promises to yield insights into the nature of autism itself.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1025918616111
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