ISSN:
0021-9541
Keywords:
Life and Medical Sciences
;
Cell & Developmental Biology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Biology
,
Medicine
Notes:
The helium group gases and nitrous oxide at superatomospheric pressures depress multiplication of HeLa cells in monolayer cultures. The effectiveness of these gases in eliciting the pressure-dependent response follows the order N2O, Xe 〉 Kr 〉 Ar 〉 〉 Ne and He. The response correlates with lipid solubility of the gases.Depression of growth by 4.2 atm Xe is reversible after exposure for one and two days. Cultures exposed to 7.2 atm Xe show irreversible damage including cytoplasmic vacuolization.Cell attachment is strongly inhibited by Xe; 36% of the cell inoculum were not attached after 24 hours. Affinity for hydrophobic sites in the cell is suggested as determining the order of effectiveness of the gases in evoking the response.
Additional Material:
6 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jcp.1040690315
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