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Experimental metastasis correlates with cyclic AMP accumulation in B16 melanoma clones (1984)

Sheppard, J. R. ; Koestler, Thomas P. ; Corwin, Steven P. ; [et al.]

[s.l.] : Nature Publishing Group

Nature 308 (1984), S. 544-547

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ISSN: 1476-4687

Source: Nature Archives 1869 - 2009

Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics

Notes: [Auszug] B16 clones were isolated and cultured in vitro as described previously6-8. Challenge with MSH or forskolin and measurement of cellular cyclic AMP was performed as described in Table 1 legend. MSH binds to specific cell-surface receptors that are coupled via a regulatory protein(s) to adenylate ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/308544a0

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Recruitment of exogenous macrophages into metastases at different stages of tumor growth (1987)

Bugelski, Peter J. ; Kirsh, Richard ; Buscarino, Charles ; [et al.]

Springer

Cancer immunology immunotherapy 24 (1987), S. 93-98

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ISSN: 1432-0851

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary The endogenous tumor-associated macrophage content and recruitment of labeled peritoneal exudate cells into experimental murine B16 melanoma metastases has been examined at different stages in the progressive growth of metastatic lesions. The recruitment of thioglycollate-elicited peritoneal exudate cells and peritoneal exudate cells activated in vitro with muramyl dipeptide was studied. Tumor-associated macrophages and labeled peritoneal exudate cells were identified in paraffin sections by specific histochemical staining and their density in individual metastases measured morphometrically. The density of tumor-associated macrophages and exogenously recruited peritoneal exudate cells was high in very small lesions but decreased rapidly as a function of enlargement of metastases, MD:An; where MD is macrophage density, A is the cross-sectional area of the lesion and n is a negative number. No significant difference was observed in the recruitment of activated and nonactivated peritoneal exudate cells. These results suggest that decreased recrutiment of macrophages from the circulation may explain the decrease in the density of tumor-associated macrophages as metastases grow and indicate that macrophage activation is not accompanied by enhanced localization and/or uptake of macrophages into metastases.