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  • 1
    Electronic Resource
    Electronic Resource
    Preparation of Antisera to Human Folliclestimulating Hormone (1963)
    [s.l.] : Nature Publishing Group
    Nature 197 (1963), S. 388-389 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The method of fractionation was by starch-gel electrophoresis, which is described fully elsewhere2. The segment of gel containing the follicle-stimulating hormone activity was eluted in saline, mixed with bentonite and given intravenously to rabbits or intraperi-toneally to mice. The total dose ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/197388b0
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  • 2
    Electronic Resource
    Electronic Resource
    Gonadotrophins in Human Urine (1954)
    [s.l.] : Nature Publishing Group
    Nature 173 (1954), S. 85-86 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Urine was collected from young nurses with regular menstruation, during the luteal phase of the cycle. It was extracted with kaolin3, and a portion of the crude gonadotrophic extract thus obtained was fractionated by chromatography. We have now compared the biological activity of the first ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/173085b0
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  • 3
    Electronic Resource
    Electronic Resource
    Purification and Lability of Human Follicle-Stimulating Hormone (1966)
    [s.l.] : Nature Publishing Group
    Nature 209 (1966), S. 1092-1093 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE starting materials for the present investigations were obtained from acetone-dried human pituitary powder by the method of Butt, Crooke and Cunningham1. Most of the luteinizing hormone (LH) was removed from the follicle-stimulating hormone (FSH) by absorption on a column of CM-cellulose. The ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2091092a0
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  • 4
    Electronic Resource
    Electronic Resource
    Gonadotrophin-inhibiting Action of Certain Carbohydrates (1966)
    [s.l.] : Nature Publishing Group
    Nature 211 (1966), S. 975-976 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Synthetic D-NANA was obtained from the Koch-Light laboratories and related compounds were synthesized in this Department. Before they were injected into animals, these compounds were dissolved in water and carefully neutralized with dilute sodium hydroxide if necessary. The uterine weight assay5 ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/211975a0
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  • 5
    Electronic Resource
    Electronic Resource
    Administration of N -Acetyl- D -mannosamine to Mammals (1966)
    [s.l.] : Nature Publishing Group
    Nature 211 (1966), S. 976-977 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] JV-Acetyl-i)-mannosamine has a pleasant, bland, sweetish taste. It has not been found free in human serum but has been reported to occur in human semen2. In mammals it is interconvertible with its 6-phosphate3 and with NANA4 by way of condensation with pyruvate. It can be assayed in aqueous ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/211976a0
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  • 6
    Electronic Resource
    Electronic Resource
    Review of 59 patients with hypergonadotrophic amenorrhoea (1984)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 91 (1984), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. Fifty-nine patients presented with elevated concentrations of gonadotrophins and secondary amenorrhoea before the age of 35 years. Fifty-three underwent laparoscopic examination and primordial follicles were observed in 16. Two others had follicles as they later became pregnant and a third showed biochemical evidence of spontaneous ovulation. There were streak ovaries in 12, two with follicles and three others with chromosomal abnormalities, two being 47XXX and one XO/XX. Two other patients had only one ovary each but no follicles. Chromosomal abnormalities were detected in two further patients one being XO/XX and the other a recombinant. Six patients became pregnant, two of them twice, resulting in four term deliveries and four spontaneous abortions. Three other patients showed biochemical evidence of ovulation; one spontaneously, one after oestrogen therapy and the third after treatment with gonadotrophin releasing hormone analogue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1984.tb05280.x
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  • 7
    Electronic Resource
    Electronic Resource
    Maternal plasma concentrations of β-lipotrophin, β-endorphin and γ-lipotrophin throughout pregnancy (1983)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 90 (1983), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. Plasma β-LPH, β-EP and γ-LPH concentrations were measured by radioimmunoassay in 10 pregnant women from 12 weeks gestation until term and in nine women in the early follicular phase of the cycle. There was a progressive and significant rise in the concentration of all three peptides throughout pregnancy and by 32 weeks the concentrations of β-LPH and β-EP were greater than the corresponding concentrations in the follicular phase: γ-LPH was greater than in the follicular phase by the end of pregnancy in those women who were delivered after 40 weeks. The ratio of β-LPH to γ-LPH did not change significantly throughout pregnancy, but there was a progressive fall in the β-LPH/β-EP ratio. The possible presence of a ‘big LPH’ to explain this finding is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1983.tb06462.x
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  • 8
    Electronic Resource
    Electronic Resource
    Maternal and cord plasma concentrations of β-lipotrophin, β-endorphin and γ-lipotrophin at delivery; effect of analgesia (1983)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 90 (1983), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. Maternal venous plasma concentrations of β-LPH, β-EP and γ-LPH were compared in (i) patients undergoing vaginal delivery, 11 with an epidural block and 13 with pethidine and nitrous oxide or no analgesics; (ii) patients delivered by caesarean section, 7 under epidural block and 8 under general anaesthesia. Patients delivered by either method under epidural block had significantly lower levels of all three peptides than those receiving no epidural. There were significant negative correlations between umbilical vein β-LPH, β-EP and γ-LPH concentrations and umbilical artery pH and positive correlations between β-LPH and β-EP but not γ-LPH and cord PCO2 in 29 patients. There was no relation between cord levels of any of the three peptides and the method of analgesia or the route of delivery. Although concentrations of all three peptides were closely correlated to one another in either maternal or cord plasma, there was no relationship between maternal and fetal levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1983.tb06463.x
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  • 9
    Electronic Resource
    Electronic Resource
    A clinical trial using danazol for the treatment of premenstrual tension (1987)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 94 (1987), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. Forty women with premenstrual tension received either placebo, 100, 200 or 400 mg danazol daily for 3 months in a pilot study arranged as a double-blind trial. Thirteen patients withdrew by the third month usually because they complained of no improvement. They had significantly higher pretrial symptom scores than those who continued. In patients treated with danazol, symptom scores for breast pain during the second and third months and for irritability, anxiety and lethargy during the third month were significantly (P〈0.05) lower than scores in those given placebo. Most symptoms improved on placebo in the first month but by the third month only three remained improved. In contrast eight symptoms were improved on 200 mg danazol by the third month. By the end of the trial more than 75% of patients who were still taking danazol were essentially free of breast pain, lethargy, anxiety and increased appetite, but results for other common symptoms were no better than with placebo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1987.tb02248.x
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  • 10
    Electronic Resource
    Electronic Resource
    Hormonal studies in women with premenstrual tension (1985)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 92 (1985), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. Serum hormone concentrations were determined at intervals during the last 17 days of the menstrual cycle in 35 patients with premenstrual tension (PMT) and 11 control subjects without symptoms. The maximum mean concentration of oestradiol occurred 17 days before menstruation in the patients and 14 days before in the controls. The maximum concentrations of progesterone were similar in the two groups but the mean concentrations rose carlier in the cycle in the patients with PMT. These results suggested that the patients tended to ovulate earlier in the cycle than the controls and on the basis of the ovulatory surge in gonadotrophins two groups could be identified, group A who showed signs of ovulation 14 days or less before menstruation (17 patients, 9 controls) and group B who ovulated more than 14 days before menstruation (18 patients, 2 controls). There were no significant differences between the groups in prolactin, thyroid stimulating hormone or testosterone levels, but cortisol concentrations were uniformly higher in both groups of patients compared with those in the controls. Follicular growth was assessed with ultrasound in 18 patients and 16 control subjects. Mean follicular diameters were significantly lower in the patients than in the control group at the time of ovulation. Oestradiol determinations done at the same time correlated with the diameters and were also significantly lower in the patient group. The results suggest that ovulation tends to occur prematurely in women with PMT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1985.tb01090.x
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