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  • 1
    Electronic Resource
    Electronic Resource
    Deglycosylation of chondroitin sulfate proteoglycan and derived peptides (1990)
    s.l. : American Chemical Society
    Biochemistry 29 (1990), S. 907-914 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00456a009
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  • 2
    Electronic Resource
    Electronic Resource
    Seasonal cycles in the carotenoid content in Mytilus edulis (1969)
    Springer
    Marine biology 4 (1969), S. 227-232 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The carotenoid content of Mytilus edulis was studied over a period of 3 years from 1965 to 1967; a seasonal cycle was observed which appeared to be controlled by the spring bloom of phytoplankton, and the sexual cycle of the mussel. Infestation by the copepod Mytilicola intestinalis and hours of exposure in the tidal cycle were found to contribute to variations in carotenoid content. Maturation of the gonads and spawning occurred in the late spring and early summer of the period studied. In addition, a second sexual phase was recorded in October 1967. The possible effect of exposure on the time of spawning is discussed. Lack of food affects both carotenoid content and the maturation of the gonads. M. edulis kept at 10 °C with little food showed no seasonal variation in the carotenoid content when compared with animals fresh from the shore. Lack of food resulted in regression in gonadal tissue after a period of time, and an absence of mature and spawning individuals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00393898
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  • 3
    Electronic Resource
    Electronic Resource
    The occurrence and effects of Mytilicola intestinalis in Mytilus edulis (1970)
    Springer
    Marine biology 5 (1970), S. 89-95 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Mytilicola intestinalis was observed in the mussel Mytilus edulis in increasing numbers for the first time at Brighton (England), in October 1966; the populations here and at Whitstable were examined. Mussels exposed high in the littoral zone were less heavily infected than those lower down, the degree of infection being directly related to the duration of exposure in each tidal cycle. Silt in the intestine of the mussel is considered to act as a controlling factor in numbers of parasites present at Whitstable. Egg-bearing copepods were present in samples throughout the year, suggesting that breeding is not interrupted by the winter. Evidence indicates that juvenile stages of the parasite cause most damage to the host, due in part to their presence in the ramifications of the hepatopancreas. Recovery of the mussel from the effects of parasitation is rapid, following a reduction in parasite population density and number of juveniles. In the laboratory, M. edulis is more rapidly affected by lack of food at 10 °C than M. intestinalis. No dead parasites were seen during 4 months of laboratory storage. Juvenile parasites continned to mature, indicating that this period of time may be required for Mytilicola intestinalis to reach maturity at 10°C.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00352497
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Mapping of a candidate region for susceptibility to inclusion body myositis in the human major histocompatibility complex (1999)
    Springer
    Immunogenetics 49 (1999), S. 508-516 
    Details
    ISSN: 1432-1211
    Keywords: Key words Inclusion body myositis ; Ancestral haplotypes ; MHC ; HSP70 ; TNF ; Microsatellites
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  Inclusion body myositis (IBM) is a form of idiopathic inflammatory myopathy of unknown aetiology. A strong association with HLA class II (HLA-DR3) suggested a role for genes in the human major histocompatibility complex (MHC) in the predisposition to this disease. In this study, we have taken advantage of the ancestral haplotype (AH) concept and historical recombinations to map for a possible susceptibility gene(s) in the MHC. We performed detailed typing of three MHC-related HSP70 genes and defined allelic combinations in the context of MHC AH. We also modified existing methods to give a simple and accurate method for typing two TNF microsatellites. Using the HSP70 and TNF markers and HLA-DR, –B, and C4 typing of our patients with IBM, we defined a potential site for the MHC-associated susceptibility gene(s) in the region between HLA-DR and C4.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002510050528
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  • 5
    Electronic Resource
    Electronic Resource
    Cystic fibrosis screening in neonates – measurement of immunoreactive trypsin and direct genotype analysis for ΔF508 mutation (1994)
    Springer
    European journal of pediatrics 153 (1994), S. 569-573 
    Details
    ISSN: 1432-1076
    Keywords: Key words     Cystic fibrosis ; Screening ; Infant ; Trypsin ; Mutation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract      This study investigated the clinical usefulness of screening for cystic fibrosis (CF) in 19992 newborns, over 39 months, in an Austrian population. Immunoreactive serum trypsin (IRT) determination was followed by sweat chloride analysis (sweat test) to establish diagnosis. In a retrospective analy- sis covering 6 months of the study period, individuals who were con- sidered to be at risk after IRT estimation (n = 22) were analysed for DF508 mutation, using a new method of DNA extraction from the initial dried blood specimens. A total of 119 infants (0.6%) had values greater than 750 ng trypsin/ml whole blood. In 88 babies sweat tests were performed, leading to the diagnosis of CF in 11 cases. One patient was not initially identified by screening but was later discovered due to his clinical status. Three infants were noted to carry the ΔF508 mutation (1 homozygous, 2 heterozygous). Two of these babies already had CF. The second heterozygote was a carrier. A highly efficient three tier screening strategy is presented in which IRT estimation, determination of ΔF508 status and sweat chloride testing could lead to a high sensitiv- ity analysis of this population.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050192
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  • 6
    Electronic Resource
    Electronic Resource
    Cystic fibrosis screening in neonates — measurement of immunoreactive trypsin and direct genotype analysis for ΔF508 mutation (1994)
    Springer
    European journal of pediatrics 153 (1994), S. 569-573 
    Details
    ISSN: 1432-1076
    Keywords: Cystic fibrosis Screening ; Infant ; Trypsin Mutation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study investigated the clinical usefulness of screening for cystic fibrosis (CF) in 19992 newborns, over 39 months, in an Austrian population. Immunoreactive serum trypsin (IRT) determination was followed by sweat chloride analysis (sweat test) to establish diagnosis. In a retrospective analysis covering 6 months of the study period, individuals who were considered to be at risk after IRT estimation (n = 22) were analysed for ΔF508 mutation, using a new method of DNA extraction from the initial dried blood specimens. A total of 119 infants (0.6%) had values greater than 750mg trypsin/ml whole blood. In 88 babies sweat tests were performed, leading to the diagnosis of CF in 11 cases. One patient was not initially identified by screening but was later discovered due to his clinical status. Three infants were noted to carry the ΔF508 mutation (1 homozygous, 2 heterozygous). Two of these babies already had CF. The second heterozygote was a carrier. A highly efficient three tier screening strategy is presented in which IRT estimation, determination of ΔF508 status and sweat chloride testing could lead to a high sensitivity analysis of this population.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02190660
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  • 7
    Electronic Resource
    Electronic Resource
    Preterm labour and delivery (1996)
    Springer
    European journal of pediatrics 155 (1996), S. S2 
    Details
    ISSN: 1432-1076
    Keywords: Preterm labour ; Tocolysis ; Nitric oxide ; Glyceryl trinitrate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Preterm birth is a major cause of perinatal morbidity and mortality. It accounts for 5–10% of all births, and any treatment to prevent it could have a profound effect on neonatal outcome in both human and economic terms. The pathogenesis of both term and preterm birth remain poorly understood. Our ability to predict those at risk of preterm labour is also inaccurate, despite the creation of scoring systems, uterine activity monitoring, cervical ultrasound and several biochemical markers. Current drug therapies for preterm labour have not been shown in randomised controlled trials to significantly affect perinatal morbidity and mortality. Furthermore, most are associated with significant maternal or fetal side effects. Nitric oxide (NO) is a potent smooth muscle relaxant, produced when NO synthase acts on the amino acidl-arginine. Its presence has been demonstrated in human myometrium. We have conducted an observational study which has suggested that glyceryl trinitrate (GTN), an NO donor, may be effective in prolonging gestation. A randomised trial comparing GTN to intravenous ritodrine is currently recruiting patients; results will be available in the Spring of 1997. Few side effects have so far been encountered. Evidence suggests that GTN, an NO donor, should be a safe and effective tocolytic and early observations are encouraging; randomised trials currently underway should determine the significance of this breakthrough in the management of preterm labour.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01958072
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  • 8
    Electronic Resource
    Electronic Resource
    Preterm labour and delivery (1996)
    Springer
    European journal of pediatrics 155 (1996), S. S2 
    Details
    ISSN: 1432-1076
    Keywords: Key words Preterm labour ; Tocolysis ; Nitric oxide ; Glyceryl ; trinitrate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Preterm birth is a major cause of perinatal morbidity and mortality. It accounts for 5–10% of all births, and any treatment to prevent it could have a profound effect on neonatal outcome in both human and economic terms. The pathogenesis of both term and preterm birth remain poorly understood. Our ability to predict those at risk of preterm labour is also inaccurate, despite the creation of scoring systems, uterine activity monitoring, cervical ultrasound and several biochemical markers. Current drug therapies for preterm labour have not been shown in randomised controlled trials to significantly affect perinatal morbidity and mortality. Furthermore, most are associated with significant maternal or fetal side effects. Nitric oxide (NO) is a potent smooth muscle relaxant, produced when NO synthase acts on the amino acid l-arginine. Its presence has been demonstrated in human myometrium. We have conducted an observational study which has suggested that glyceryl trinitrate (GTN), an NO donor, may be effective in prolonging gestation. A randomised trial comparing GTN to intravenous ritodrine is currently recruiting patients; results will be available in the Spring of 1997. Few side effects have so far been encountered. Evidence suggests that GTN, an NO donor, should be a safe and effective tocolytic and early observations are encouraging; randomised trials currently underway should determine the significance of this breakthrough in the management of preterm labour.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01958072
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Influence of smoking and gender on the disposition kinetics of metoprolol (1987)
    Springer
    European journal of clinical pharmacology 33 (1987), S. 355-361 
    Details
    ISSN: 1432-1041
    Keywords: metoprolol ; smoking ; gender ; pharmacokinetics ; HPLC ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The purpose of this study was to examine the influence of cigarette smoking and gender on the pharmacokinetics of metoprolol. Eighteen volunteers with no evidence of clinical disease each randomly received the following doses of metoprolol tartrate: 100 mg orally, 200 mg orally and 20 mg as a constant-rate intravenous infusion over 20 min. The only significant difference between smokers (S) and nonsmokers (NS) was that S had a larger steady-state volume of distribution (3.3 vs 2.5 l/kg). There were no differences in half-life, systemic clearance or bioavailability (f). No differences were observed between males (M) and females (FM) for any of the kinetic parameters examined. Systemic bioavailability varied markedly between subjects (range: 15 to 92%). In fifteen of the eighteen subjects, f was higher after the 200-mg dose compared to the 100-mg dose. These results suggest that metoprolol may be subject to saturable presystemic elimination and extend the previous observations of Johnsson et al. [1] who showed that f increased from 31% to 46% when doses were increased from 20 to 100 mg. However, the difference in f as the dose is increased is unlikely to be clinically significant since the mean difference is smaller than the variation in f among subjects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00637630
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Doppler fetal circulation in pregnancies complicated by pre-eclampsia or delivery of a small for gestational age baby: 2. Longitudinal analysis (1999)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 106 (1999), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To observe the longitudinal changes in growth, and associated Doppler measurements, of the fetal circulation in pregnancies with a normal outcome and those complicated by pre-eclampsia, birth of a small for gestational age baby, or a combination of these complications.Methods Two hundred and ninety-two women had serial ultrasound scans performed from the 24th week of pregnancy. Measurements obtained included: the abdominal circumference, umbilical artery pulsatility index, the middle cerebral artery pulsatility index and time-averaged velocity, and the thoracic aorta pulsatility index and time-averaged velocity. Outcome measures included the birth of a small for gestational age infant, pre-eclampsia or a combination of these complications.Results One hundred and sixty-seven pregnancies ended in the normal birth of an appropriately grown infant at term, while 105 had a complicated outcome. They were divided into three categories: pre-eclampsia only (i.e. with the birth of an appropriately grown fetus, n= 13); small for gestational age only with no evidence of pre-eclampsia, n= 55; and pre-eclampsia complicated by the birth of a small for gestational age infant, n = 37. The group with pre-eclampsia complicated by small for gestational age was closest in characteristics to true clinical intrauterine growth restriction. A reduction in the abdominal circumference mirrored a rise in the umbilical artery pulsatility index and preceded changes in the middle cerebral artery and thoracic aorta. The greatest degree of change in the fetal circulation was observed during the three weeks preceding delivery. Ratios of the values obtained from the fetal and umbilical circulation demonstrated the greatest deviation from normal.Conclusions A reduction in fetal growth velocity preceded changes observed in the fetal circulation. Ratios of the fetal Doppler parameters provided the clearest evidence of deterioration in the fetal condition. The information provided may be of use in the diagnosis and management of the growth-restricted fetus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1999.tb08299.x
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