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Glucosaminylmuramyl dipeptide (GMDP) modulates endothelial cell activities in vitro but has no effect on angiogenesis in vivo (1997)

Li, C. G. ; Kumar, S. ; Ledger, P. W. ; [et al.]

Springer

Inflammation research 46 (1997), S. 348-353

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ISSN: 1420-908X

Keywords: Key words: Glucosaminylmuramyl dipeptide — Human umbilical vein endothelial cells — ICAM-1 — CD31 — Cell adhesion

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract. Objective and Design: The aim of the study was to evaluate the effects of GMDP on angiogenesis in vivo and as a modulator of human umbilical vein endothelial cell proliferation, cell surface antigen expression and cell adhesion in vitro.¶Materials: Human umbilical vein endothelial cells (HUVEC), fertilized white leghorn chicken eggs, antibodies against adhesion molecules and glucosaminylmuramyl dipeptide (GMDP).¶Treatment: GMDP [0.01–100 μg/ml] applied to cell cultures for 6–72 h and to the chick chorioallantoic membrane (CAM) for four days.¶Methods: Angiogenic activity of GMDP in vivo was assessed using the CAM assay; HUVEC proliferation was measured by tritiated thymidine incorporation and cell cycle studies; cell surface antigen expression by indirect immunofluorescence and flow cytometry; cell adhesion by quantification of [3H]-thymidine labeled leukocyte adherence to HUVEC monolayers. Statistical analysis was performed using one-way ANOVA and if necessary was followed by Duncan's multiple range test for variables.¶Results: GMDP induced [3H]-thymidine incorporation in a concentration- and time-dependent manner (p 〈 0.003) and significantly increased the proportion of cells in the S phase of the cell cycle (p 〈 0.03). It weakly augmented the expression of ICAM-1 and CD31 but not adhesion of leukocytes to HUVEC monolayers GMDP was not angiogenic in the CAM assay.¶Conclusions: GMDP can modulate endothelial cell activity without the induction of angiogenesis in vivo which may have implications for its use as a therapeutic agent.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s000110050200

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Anastomoses between the spermatic and visceral veins:a retrospective study of 500 consecutive patients (1997)

Bigot, J.-M. ; Le Blanche, A.-F. ; Carette, M.-F. ; [et al.]

Springer

Abdominal imaging 22 (1997), S. 226 -232

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ISSN: 1432-0509

Keywords: Key words: Vein, portal—Vein, anastomosis—Veins, anatomy—Phlebography, spermatic.

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract. Background: Do visceral–spermatic vein shunts have any clinical impact on sclerotherapy of varicoceles? Methods: The spermatic venograms of 500 consecutive patients were retrospectively reviewed to classify visceral–spermatic communications. Men with an average age of 27.8 years (range 11–65 years old) underwent sclerotherapy of a varicocele. Of the 500 men, 445 were referred for oligoasthenospermia (89%), 45 for pain (9%), and 10 for prevention of infertility (2%). After bilateral catheterization, percutaneous sclerosis was performed below the upper third of the sacroiliac joint. Results: Three hundred forty patients (68%) had left-sided, 10 (2%) had right-sided, and 150 (30%) had bilateral varicoceles. Left side: Of 46 (9.4%) anastomoses, one (0.2%) communicated with the splenic vein and 45 (9.2%) with the inferior mesenteric vein of which 25 (5.1%) were a colic trunk with a competent valve, 15 (3.1%) were venules, and five (1%) were a single or double anastomosis. Right side: Of 48 (29.6%) anastomoses to the superior mesenteric vein, 34 (21%) were venules, 12 (7.4%) were a colic trunk with a competent valve, and two (1.2%) were a single or double vein. Our varicocele recurrence rate was only 1.2%. Conclusion: Visceral–spermatic vein communications are classified by number, morphology, and site. Percutaneous sclerotherapy could be optimized when performed caudally to these communications.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s002619900176

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Utility of CT scan for the diagnosis of chest wall tuberculosis (1999)

Khalil, A. ; Le Breton, C. ; Tassart, M. ; [et al.]

Springer

European radiology 9 (1999), S. 1638-1642

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ISSN: 1432-1084

Keywords: Key words: Bone ; Tuberculosis ; CT ; Rib ; Sternum ; Chest wall

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract. The objective of this study was to determine the utility of CT scan findings for the diagnosis of chest wall tuberculosis, excluding the spine. We reviewed 15 patients (13 Africans and 2 Indians) with chest wall tuberculosis, retrospectively. The radiologic examination consisted of a plain X-ray and a CT scan of the chest for each patient. The site of disease was the rib in 13 patients or the body of the sternum in 2 patients. One rib was involved in 11 patients, 2 contiguous ribs (one site) in 2 patients, and bilateral disease (two sites) was observed in the remaining patient. The 14 rib sites involved the posterior arc or costovertebral joint in 11 cases, the anterior arc in 2 cases, and the anterior and middle arc in 1 case. The CT scan findings were an abscess (n = 14) or a soft tissue mass (n = 2), osteolytic lesions (n = 13), periosteal reaction (n = 10), and sequestrum (n = 14). Bone sclerosis was observed only in 3 cases of rib involvement. The association of a soft tissue abscess, an osteolytic lesion, and sequestrum, especially in immigrants to France, suggests chest wall tuberculosis on CT scan.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s003300050900

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Infectious sacroiliitis: value of computed tomography (CT) and magnetic resonance imaging (MRI) (1992)

Breton, C. ; Frey, I. ; Carette, M. F. ; [et al.]

Springer

European radiology 2 (1992), S. 233-239

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ISSN: 1432-1084

Keywords: Infectious sacroiliitis ; Sacroiliac joint ; Computed tomography ; Magnetic resonance imaging

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Infectious sacroiliitis is an uncommon septic arthritis, the diagnosis of which is difficult to establish. We retrospectively examined 14 cases of septic sacroiliitis, by CT (two of whom also had an MRI examination). The patient population consisted of eight men and six women; 9 were African, 8 had tuberculous sacroiliitis and 6 pyogenic sacroiliitis. All the cases showed a pre-sacroiliac soft tissue swellilng with ring-like enhancement following intravenous contrast in eight cases. A gas image was observed at the centre of the abcess in two cases. Joint narrowing was found in four patients and widening in eight, associated with an image of bone sequestration in seven, CT gave an etiologic orientation in 8 cases, and facilitated the guidance of bone biopsy. MRI showed low signal T1-weighted images and high signal T2 of the subchondral bone, joint space and soft tissue abcess. We conclude that CT is helpful in the evaluation of infectious sacroiliitis, and that further studies are necessary to evaluate the role of MRI in such pathologic processes.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00595836

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