ISSN:
1471-0528
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Plasma oestradiol showed a two- to three-fold rise above the mean basal level by six hours after a single intravenous injection of synthetic Luteinizing Hormone and Follicle Stimulating Hormone Releasing Hormone (LH-RH/FSH-RH) in nine out of twelve patients with secondary amenorrhoea. Of the remaining three patients, two had persistently high basal plasma gonadotrophins in keeping with a diagnosis of premature menopause and one patient had secondary amenorrhoea of seven years' duration. It is suggested that a six-hour plasma oestradiol estimate be used as the endpoint of the LH-RH/FSH-RH test in order to assess the pituitary-ovarian axis. If a less than two-fold increase in plasma oestradiol is found, pituitary reserve can be more intensively studied by assaying plasma follicle stimulating hormone (FSH) and luteinizing hormone (LH).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1471-0528.1974.tb00382.x
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