ISSN:
1432-0703
Source:
Springer Online Journal Archives 1860-2000
Topics:
Energy, Environment Protection, Nuclear Power Engineering
,
Medicine
Notes:
Abstract Dietary polychlorinated biphenyls (PCBs) were evaluated in an atherosclerosis animal model during a 26-week period. Male white Carneau pigeons were maintained on diets containing either 0, 5, 25, or 125 Μg/g Aroclor® 1254. One-half of the birds from each of the four groups consumed diets which contained 0.5% cholesterol. Serum samples were analyzed after 8, 16, and 26 weeks of dietary treatment. Liver samples were analyzed for Zn and PCB content. Relative liver weight and serum glutamic-oxaloacetic transaminase (SGOT) increased with PCB consumption; however, liver Zn and serum alkaline phosphatase were negatively correlated with PCB exposure. Dietary cholesterol induced hypercholesterolemia, which was accounted for by elevation of serum low density lipoprotein cholesterol (LDL) and very-low density lipoprotein cholesterol (VLDL). Consumption of dietary PCBs was inversely related to serum high density lipoprotein cholesterol (HDL), The serum total cholesterol/HDL ratio was elevated by dietary cholesterol but not by PCBs. The serum HDL/LDL ratio was depressed by dietary cholesterol but not by PCBs. Chronic lowering of serum HDL associated with hypercholesterolemia and a decreased serum HDL/LDL ratio, as observed in this study, would be expected to exacerbate atherosclerosis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01055167
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