ISSN:
0942-0940
Keywords:
Meningioma
;
oestrogen receptor
;
progesterone receptor
;
histologic features
;
tumoural subtypes
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary A series of 39 samples were obtained from meningiomas in 28 patients in order to investigate the relationships of the oestrogen receptor (OER) and progesterone receptor (PR) with the tumoural subtype and some histological features. Twenty-one samples were positive (〉 10 fmole/mg protein), 7 were OER-PR-negative, and 1 was positive in both receptors. Twenty-two samples were considered as syncitial, 7 transitional, 7 fibroblastic and 3 angioblastic. The histological subtype was not found to be significantly related to the presence or absence of PR. Relations were not observed between the progestin receptor and the following histological parametrs: cellular pattern, cell density, nuclear polymorphism, mitosis, lymphoplasmacellular infiltrates, degree of vascularization, psammoma bodies and interstitial fibrosis. Only the presence of intratumoural necrosis was significantly related with a low PR levels. However, progesterone binding activity was lower in tumours with numerous psammomas, fibroblastic cell pattern and interstitial fibrosis. The clinical and biological significance of these results is discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01402046
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