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Intrahepatic CD4+ T-Cell Apoptosis is Related to METAVIR Score in Patients With Chronic Hepatitis C Virus (2005)

Roger, P.-M. ; Chaillou, S. ; Breittmayer, J.-P. ; [et al.]

Oxford, UK; Malden, USA : Blackwell Science Ltd

Scandinavian journal of immunology 62 (2005), S. 0

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ISSN: 1365-3083

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Hepatitis C virus (HCV) infection leads to liver injury, which is thought to be immune-mediated. Apoptosis of hepatic T cells could influence histological damage. We quantified peripheral and intrahepatic T-cell apoptosis in 28 patients with chronic hepatitis C by using cytofluorometric techniques. METAVIR score and HCV plasma viral load were determined. Six liver biopsies, obtained from controls without chronic hepatitis during hepatobiliary surgery, served as controls. In patients, liver T-cell apoptosis was upregulated compared to peripheral T cells: 35 versus 7% for CD4+ and 56 versus 13% for CD8+ T cells (P 〈 0.001). Liver T-cell apoptosis levels from patients were increased compared to controls for both CD4+ (P = 0.041) and CD8+ T cells (P = 0.007). Nine patients exhibiting METAVIR scores A and F ≤1 showed higher intrahepatic CD4+ T-cell apoptosis compared to the 19 patients with a higher METAVIR score (P = 0.001) and both histological activity and fibrosis were related to apoptosis level. There was also an inverse relationship between the level of intrahepatic CD8+ T-cell apoptosis and serum transaminase activity (P = 0.023). Our study shows immune compartmentalization, suggesting that the study of peripheral blood lymphocytes may not be fully relevant to the pathophysiology of HCV hepatitis, and that the severity of liver injury is inversely correlated with intrahepatic CD4+ T-cell apoptosis.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1365-3083.2005.01648.x

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Nitrate or ammonium nutrition in french bean (1986)

Chaillou, S. ; Morot-Gaudry, J. -F. ; Lesaint, C. ; [et al.]

Springer

Plant and soil 91 (1986), S. 363-365

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ISSN: 1573-5036

Keywords: Ammonium ; Metabolism ; Nitrate ; Phaseolus vulgaris L.

Source: Springer Online Journal Archives 1860-2000

Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition

Notes: Summary Bean Plants were grown in a greenhouse in sand irrigated with nutrient solutions containing either 2 mM NO 3 − or 2 mM NH 4 + . After 45 days fresh weight of NH 4 + plants was half that of NO 3 − plants. Cation concentration in NH 4 + plants was 30% less than in NO 3 − plants. Amino acids (SER, ASN, GLN) accummulated 3 to 10 times more in NH 4 + plants. The concentration of organic acids (malic, malonic, citric) was 10 to 30 times higher in NO 3 − plants. The ATP-costings for the synthesis of amino acids and organic acids in NH 4 + plants was half that of NO 3 − ones: therefore it could not account for the reduction of growth in the ammonium-fed plants.