ISSN:
0749-1581
Keywords:
Crisnatol
;
Metabolites
;
COSY
;
RCOSY
;
HMQC
;
HMBC
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
NMR and mass spectral data are presented in support of the structures of two metabolites of crisnatol, 2-[(6-chrysenylmethyl)amino]-2-methylpropane-1,3-diol, a novel DNA intercalator currently undergoing Phase II clinical trials as an anticancer agent. Elucidation of the structures of the major rat urinary metabolite as trans-1,2-dihydro-1,2-dihydroxycrisnatol, and the major rat fecal metabolite as 1-hydroxycrisnatol, using 2D NMR techniques are described.
Additional Material:
5 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260300303
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