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  • 1
    ISSN: 1432-1106
    Keywords: Hyperthermic treatment ; Apneic hypoxia ; Electroencephalogram ; Heat-shock protein ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Electroencephalography (EEG) was utilized for investigating the effect of hyperthermia followed by apneic hypoxia in rats. They were heated whole-bodily to 41° C for 15 min under the control of an artificial rodent ventilator, after drug-induced generalized paralysis. A transcutaneous oxygen saturation monitor was applied to detect the hypoxic condition. EEG was monitored with bipolar needle electrodes. The 72-kDa heatshock protein (HSP72) in brain was analyzed by sodium dodecyl sulfate-polyacrylamide electrophoresis, followed by immunostaining with an anti-HSP72 antibody. There was no difference in the time interval from onset of apneic hypoxia to flat EEG between the hyperthermic and control groups, but cortical electrical activity appeared earlier in the hyperthermia group than the control group, after 90 s of ventilation interruption. The cardiac function did not change in the two groups. The HSP72 synthesis significantly increased in the brain of the rats with hyperthermic treatment.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Development Economics 26 (1987), S. 277-289 
    ISSN: 0304-3878
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Political Science , Economics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Development Economics 39 (1992), S. 397-407 
    ISSN: 0304-3878
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Political Science , Economics
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Development Economics 24 (1986), S. 119-129 
    ISSN: 0304-3878
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Political Science , Economics
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aims:  To investigate whether localization of β-catenin is helpful in differentiating primary ovarian mucinous carcinoma and colorectal adenocarcinoma metastatic to the ovary. Extra-ovarian cancers which metastasize to the ovaries, especially from colorectal adenocarcinoma, frequently mimic primary ovarian carcinomas, particularly endometrioid and mucinous types. Distinguishing primary ovarian carcinoma from metastatic colorectal carcinoma is important for both therapeutic and prognostic reasons. Even after thorough histological examination, metastatic colorectal adenocarcinomas are still often mistaken for primary ovarian adenocarcinomas. Although some tumour makers have been advocated and are helpful in most cases, sometimes the distinction between primary mucinous carcinoma and metastatic colorectal carcinoma remains a problem. Activation of Wnt signalling through mutations of APC or β-catenin is a key event in the development of colorectal cancer. These mutations lead to nuclear localization of β-catenin, which can be demonstrated immunohistochemically.Methods and results:  Formalin-fixed paraffin-embedded specimens from 43 primary ovarian mucinous carcinomas and 23 metastatic colorectal adenocarcinomas were included in this study. Sections were immunostained with antibodies to β-catenin, cytokeratin (CK)7, CK20 and carcinoembryonic antigen (CEA). Nuclear localization of β-catenin was found in 83% (19/23) of metastatic colorectal cancers and 9% (4/43) of ovarian mucinous carcinomas. Ovarian mucinous carcinomas were usually positive for CK7 (34/43, 79%). For comparison, 40 non-mucinous carcinomas of the ovary and 42 metastatic adenocarcinomas from other organs were also immunostained with antibodies against β-catenin. Although nuclear localization of β-catenin was occasionally seen in non-mucinous carcinoma of the ovary and metastatic adenocarcinoma from other organs, such tumours were usually distinguishable by their clinicopathological picture and rarely raised diagnostic problems.Conclusions:  Immunostaining of β-catenin is a useful marker for differentiating between ovarian mucinous carcinoma and metastatic colorectal adenocarcinoma.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Optics Communications 84 (1991), S. 359-364 
    ISSN: 0030-4018
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of International Economics 23 (1987), S. 315-328 
    ISSN: 0022-1996
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Economics
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Tetrahedron Letters 22 (1981), S. 3823-3826 
    ISSN: 0040-4039
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 22 (2005), S. 0 
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : Little is known about the social and medical burdens of heartburn in Asia.Aim : To assess the impact of heartburn in Taiwan.Methods : We applied a questionnaire to 2018 apparently healthy adult Chinese receiving a routine health maintenance programme. Costs of heartburn-related prescriptions were obtained from the Bureau of National Health Insurance of Taiwan.Results : Heartburn prevalence (〉1 episode/week) was 7%. Smoking and increased body mass index were associated with heartburn occurrence. Heartburn sufferers reported more atypical gastro-oesophageal reflux disease symptoms, e.g. chest pain, dysphagia and globus. They were more likely to consult physicians, and have an increased frequency and number of days of absenteeism, irrespective of upper gastrointestinal or nongastrointestinal-related illnesses. They experienced sleep disturbances more frequently. The 62 heartburn consulters (48%) were more likely to have co-existing globus, visited physicians more, had more absenteeism, suffered from more sleep disturbances and had higher costs for antacids, proton pump inhibitors, hypnotic/sedatives, tranquilizers and antidepressants than nonconsulters.Conclusions : Heartburn prevalence in Taiwan is lower than in Western countries. Nevertheless, heartburn in Taiwanese creates a significant burden in terms of social impact, health resource utilization, sleep quality and pharmaceutical costs. The increased costs of psychoactive drugs in consulters suggest that anxiety/depression affects their health-seeking behaviour.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Colloid & polymer science 275 (1997), S. 1060-1067 
    ISSN: 1435-1536
    Keywords: Key words Miniemulsion polymerization ; nonionic surfactant ; reactive cosurfactants ; styrene ; emulsion stability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Summary  A nonionic surfactant, nonylphenol polyethoxylate with an average of 40 ethylene oxides per molecule (NP-40), in combination with a reactive cosurfactant such as dodecyl methacrylate (DMA) or stearyl methacrylate (SMA) was used to prepare stable styrene miniemulsions in this study. Like conventional cosurfactants such as cetyl alcohol (CA) and hexadecane (HD), the reagent DMA or SMA may act as a cosurfactant in stabilizing the homogenized miniemulsions. Furthermore, the methacrylate group can be chemically incorporated into latex particles in subsequent miniemulsion polymerization, as shown by the IR spectra. The rate of Ostwald ripening for these miniemulsions in the decreasing order is: CA〉 DMA〉HD∼SMA. This trend correlates well with the water solubility of these cosurfactants. The lower the levels of NP-40 and DMA, the greater is the degree of Ostwald ripening. This is because the DMA concentration is not high enough to counteract diffusional degradation of monomer droplets. Polystyrene latex particles were produced via both monomer droplet nucleation and homogeneous (or micellar) nucleation for the system exhibiting strong Ostwald ripening and/or droplet coalescence during the very early stage of polymerization. On the other hand, monomer droplet nucleation becomes more important for the system showing weak Ostwald ripening. Temperature has an important influence on the shelf-life of miniemulsions and subsequent polymerization. This is attributed to the fact that hydrogen bonds between the polyethylene oxide part of NP-40 and water are quite sensitive to changes in temperature.
    Type of Medium: Electronic Resource
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