ISSN:
1435-0130
Keywords:
Venous flaps
;
GSH
;
SOD
;
ATP-MgCl2
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Oxygen-derived free radicals and the energy supply for resynthesis are important factors that affect flap survival. An experimental rabbit model was designed to investigate the effects of the free radical scavengers, glutathione (GSH), superoxide dismutase (SOD), and adenosine triphosphate (ATP-MgCL2), on venous flap survival. Four 4×6 cm flaps were elevated in each animal along the axis of the thoraco-epigastric veins. Postoperatively, the agents were administered intravenously and relative flap survival was measured after two weeks. Mean flap survival, using the free radical scavengers, ranged between 76 and 87%, which showed a significant improvement over saline controls (68.73%, p〈0.01). The respective mechanisms of the individual agents are discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00176271
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